Factores pronósticos y sobrevida a mediano plazo de una cohorte de pacientes con cáncer pulmonar atendidos en la red de salud de la Universidad Católica: Período 2007-2011

Abstract

Factores pronósticos y sobrevida a mediano plazo de una cohorte de pacientes con cáncer pulmonar atendidos en la red de salud de la Universidad Católica. Período Lung cancer is the leading cause of death from malignancy worldwide. In Chile the magnitude of the problem and the diagnosis-associated survival are unknown. Methods: We examined a cohort of 202 adult patients with lung cancer histologically confirmed in a single health network between January 2007 and December 2011. We accessed to medical records and images files of patients, recording the clinical, histological, imaging and staging data. Patients were followed until December 2013 to assess survival. Results: The mean age of the cohort was 68.1 ± 11.5 years, 53% were male and 86% had a smoking history. 82.2% of the cases were symptomatic at diagnosis, been cough the symptom most frequently reported. The predominant histological subtype was adenocarcinoma (42%), followed by squamous cell carcinoma (26.2%). In women, adenocarcinoma was the leading histology variety (56.4%), and in males it was adenocarcinoma (37%) and squamous cell carcinoma (33.3%). The majority of the patients were diagnosed at advanced stages of the disease. The 36-month survival rate was 46.1%. The mean survival according to clinical stage was 70.7 month in stage I, 60.3 in stage II, 47.1 in IIIA, 12.3 in IIIB and 11.7 month in stage IV. According to histological variety, the mean survival was 36.6 month in adenocarcinoma, 33.8 in squamous cell carcinoma, month in undifferentiated non small-cell carcinoma. There were no significant differences in survival by age or gender. Conclusion: The most common histological type was adenocarcinoma and short-term survival was related to the clinical staging and histological variants.

Cáncer pulmonar: caracterización, estadificación y supervivencia en una cohorte de una década en un hospital del sistema público de salud de Chile

“…nunca fumadora, especialmente en países desarrollados [22][23][24][25] . En nuestra serie el adenocarcinoma fue el tipo histológico más frecuente con 52,6% de los casos, seguido del carcinoma escamoso, lo que es similar a otro estudio nacional 26 . En nuestra serie se observó un alto porcentaje de síntomas y/o signos y de presencia de metástasis al momento del diagnóstico.…”