Factores epidemiológicos y sociodemográficos asociados al síndrome de abstinencia alcohólica complicado

Monte-Secades, Rafael; Blanco-Soto, María; Díaz-Peromingo, José Antonio; Sanvisens-Bergé, Arantza; Martín-González, M. Candelaria; Barbosa, A.; Rosón-Hernández, Beatriz; Tejero-Delgado, M.A.; Puerta-Louro, Rubén; Rey, Ramón Rabuñal

doi:10.1016/j.rce.2017.05.002

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…Eyer et al ( 44 ) reported no significant sex difference among patients with DT [males vs. females: 72% (33/46) vs. 28% (13/46), p = 0.8] and AW seizures [72% (44/61) vs. 28% (17/61), p = 0.8]. Monte et al ( 45 ) and Monte-Secades et al ( 46 ) did not find significant sex differences in complicated AWS [Monte Secades et al study: males vs. females: 47% (98/207) vs. 57% (12/21), p = 0.3], Monte et al study: [males vs. females: 26% (128/492) vs. 40% (19/47), p = 0.5].…”

Section: Resultsmentioning

confidence: 97%

“…7.4% (294/3,974) of males and 8.5% (82/966) of females experienced AW seizure ( 42–44 , 47 , 73 , 77 , 78 ). Three studies merged AWS complications (DT, hallucinations, seizures), with a total of 17.5% of males (330/1,876) and 10% of females (69/689) in these three studies developed complicated AWS ( 39 , 46 , 78 ). Wojnar et al ( 43 ) found that women were more likely than men to present with DT upon admission [males vs. females: 53.5% (996/1,862) vs. 63.6% (152/239), p < 0.01], while the frequency of AW seizures was higher in men [2.8% (52/1,862) vs. 0.5% (1/239), p < 0.001].…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, Wood et al ( 101 ) concluded in their review that having severe AWS was not more likely in men than in women [Likelihood ratio (LR) for men 1.3, 95% CI: 1.0–1.7]. Some studies report that male sex is a risk factor of developing severe AWS ( 40 , 55 ), while others do not ( 46 , 64 ).…”

Section: Discussionmentioning

confidence: 98%

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Sex difference in alcohol withdrawal syndrome: a scoping review of clinical studies

Unlu,

Macaron,

Ayraler Taner

et al. 2023

Front. Psychiatry

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BackgroundWe conducted a review of all studies comparing clinical aspects of alcohol withdrawal syndrome (AWS) between men and women.MethodsFive databases (PubMed, Cochrane, EMBASE, Scopus and Clinical Trials) were searched for clinical studies using the keywords “alcohol withdrawal syndrome” or “delirium tremens” limited to “sex” or “gender” or “sex difference” or “gender difference.” The search was conducted on May 19, 2023. Two reviewers selected studies including both male and female patients with AWS, and they compared males and females in type of AWS symptoms, clinical course, complications, and treatment outcome.ResultsThirty-five observational studies were included with a total of 318,730 participants of which 75,346 had AWS. In twenty of the studies, the number of patients presenting with or developing AWS was separated by sex, resulting in a total of 8,159 (12.5%) female patients and a total of 56,928 (87.5%) male patients. Despite inconsistent results, males were more likely than females to develop complicated AWS [delirium tremens (DT) and AW seizures, collective DT in Males vs. females: 1,792 (85.4%) vs. 307 (14.6%), and collective seizures in males vs. females: 294 (78%) vs. 82 (22%)]. The rates of ICU admissions and hospital length of stay did not show sex differences. Although variable across studies, compared to females, males received benzodiazepine treatment at higher frequency and dose. One study reported that the time from first hospitalization for AWS to death was approximately 1.5 years shorter for males and males had higher mortality rate [19.5% (197/1,016)] compared to females [16% (26/163)].ConclusionDespite the significant heterogeneity of the studies selected and the lack of a focus on investigating potential sex differences, this review of clinical studies on AWS suggests that men and women exhibit different AWS manifestations. Large-scale studies focusing specifically on investigating sex difference in AWS are needed.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

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Sex difference in alcohol withdrawal syndrome: a scoping review of clinical studies

Unlu,

Macaron,

Ayraler Taner

et al. 2023

Front. Psychiatry

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Sistema sanitario y consumo de alcohol. ¿Es posible la convivencia?

Casademont

2017

Revista Clínica Española

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Sex-specific Associations of Alcohol Withdrawal in Patients Admitted for the Treatment of Alcohol Use Disorder

Sanvisens¹,

Short

Rubio

et al. 2020

Journal of Addiction Medicine

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Objectives: There are sex differences in the pattern of alcohol consumption and in the complications of alcohol use disorder (AUD). We aimed to identify sex-specific differences in the factors associated with alcohol withdrawal syndrome (AWS) among patients that requested a first treatment for AUD. Methods: We enrolled 313 patients (75% men) with a Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) AUD diagnosis that started treatment between 2014 and 2016. We collected socio-demographics, the type and amount of alcohol and other substances consumed, and clinical and laboratory parameters. According to Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) AUD criteria, AWS occurred when patients experienced 2 or more clinical signs/symptoms and/or consumed alcohol to relieve symptoms. Logistic regression models were used to determine factors associated with AWS according to sex. Results: The median age of participants was 50 years (interquartile range [IQR]: 43–54 years). The median age of starting alcohol consumption was 16 years (IQR: 14–18 years). Notably, 69% of participants smoked tobacco, and 61% had a family history of AUD; 18% currently used cannabis, and 7.7% used cocaine. Overall, 73% of patients exhibited AWS criteria, and men (76.5%) were more likely than women (64.6%) to report AWS (P = 0.038). In the adjusted analysis, factors associated with AWS were the age at starting alcohol consumption (odds ratio [OR] for every 5 years = 1.89, 95% confidence interval [CI]: 1.69–2.08), and cannabis use (OR = 2.8, 95% CI: 1.04–7.7) in men, and a family history of AUD in women (OR = 2.85 95% CI: 1.07–7.54). Conclusions: factors associated with AWS differ by sex which may have clinical implications for proactive management of AWS during treatment for AUD.

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Factores epidemiológicos y sociodemográficos asociados al síndrome de abstinencia alcohólica complicado

Cited by 5 publications

References 25 publications

Sex difference in alcohol withdrawal syndrome: a scoping review of clinical studies

Sex difference in alcohol withdrawal syndrome: a scoping review of clinical studies

Sistema sanitario y consumo de alcohol. ¿Es posible la convivencia?

Sex-specific Associations of Alcohol Withdrawal in Patients Admitted for the Treatment of Alcohol Use Disorder

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