Background: The purpose of this study was to assess differences in factors between smoking status of Brazilians living with HIV, as well as assess whether secondhand smoke exposure or sexual orientation was associated with smoking status. Methods: Over 200 HIV infected individuals were convenience sampled. Permission was granted by the Universidade de São Paulo, and trained HIV care nurses conducted the interviews. Results: Two-hundred and five participants were interviewed of whom 39% currently smoked tobacco. Sexual orientation did not associate with smoking categories, but secondhand smoke exposure did. In the ever-smoking model lower education level was more likely to induce smoking behavior and women were 70% more likely to have smoked. In the current-smoking model, attitudes were significant, and women were 75% more likely to be currently smoking. Conclusion: Smoking prevalence is high in HIV-infected persons in Brazil. Comprehensive attention is needed to help individuals successfully quit, including emphasis on secondhand smoking risk awareness and offering coping strategies to prevail over stigma and stress, especially for women.