Factores de riesgo en la transmisión de la hepatitis B en la Amazonía colombiana

Hoz, Fernando de la; Durán, Máncel Martínez; Gamarra, Antonio lglesias; Velandia, Martha; Rojas, María del Carmen

doi:10.7705/biomedica.v12i1.2014

Cited by 11 publications

(11 citation statements)

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“…In Colombia, HDV infection is common in Amazonas and Magdalena departments [37], [38], [45], [46]. These data were confirmed in this study as the only anti-HDV positive samples found were from these two departments: 8 (8,25%)/97 and 1 (2.5%)/40 among HBsAg and/or anti-HBc positive samples from Amazonas and Magdalena departments, respectively.…”

Section: Discussionsupporting

confidence: 84%

Hepatitis B (HBV), Hepatitis C (HCV) and Hepatitis Delta (HDV) Viruses in the Colombian Population—How Is the Epidemiological Situation?

et al. 2011

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BackgroundViral hepatitis B, C and delta still remain a serious problem worldwide. In Colombia, data from 1980s described that HBV and HDV infection are important causes of hepatitis, but little is known about HCV infection. The aim of this study was to determine the currently frequency of HBV, HCV and HDV in four different Colombian regions.Methodology/Principal FindingsThis study was conducted in 697 habitants from 4 Colombian departments: Amazonas, Chocó, Magdalena and San Andres Islands. Epidemiological data were obtained from an interview applied to each individual aiming to evaluate risk factors related to HBV, HCV or HDV infections. All samples were tested for HBsAg, anti-HBc, anti-HBs and anti-HCV markers. Samples that were positive to HBsAg and/or anti-HBc were tested to anti-HDV. Concerning the geographical origin of the samples, the three HBV markers showed a statistically significant difference: HBsAg (p = 0.033) and anti-HBc (p<0.001) were more frequent in Amazonas and Magdalena departments. Isolated anti-HBs (a marker of previous vaccination) frequencies were: Chocó (53.26%), Amazonas (32.88%), Magdalena (17.0%) and San Andrés (15.33%) - p<0.001. Prevalence of anti-HBc increased with age; HBsAg varied from 1.97 to 8.39% (p = 0.033). Amazonas department showed the highest frequency for anti-HCV marker (5.68%), while the lowest frequency was found in San Andrés Island (0.66%). Anti-HDV was found in 9 (5.20%) out of 173 anti-HBc and/or HBsAg positive samples, 8 of them from the Amazonas region and 1 from them Magdalena department.Conclusions/SignificanceIn conclusion, HBV, HCV and HDV infections are detected throughout Colombia in frequency levels that would place some areas as hyperendemic for HBV, especially those found in Amazonas and Magdalena departments. Novel strategies to increase HBV immunization in the rural population and to strengthen HCV surveillance are reinforced by these results.

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Section: Discussionsupporting

confidence: 84%

Hepatitis B (HBV), Hepatitis C (HCV) and Hepatitis Delta (HDV) Viruses in the Colombian Population—How Is the Epidemiological Situation?

et al. 2011

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“…Even the average incidence of hepatitis B in Colombia corresponds to low endemicity, there are several high prevalence regions in the country well described such as Amazonia, Orinoquia, the Sierra Nevada de Santa Marta and the Serrania de Perija. The heterogeneity of HBV prevalence in the country is mainly due to ethnic, socioeconomic, cultural and geographic differences [ 1 , 20 , 21 , 22 , 23 ]. Furthermore, recently a low coverage of timely birth dose of the vaccine in rural communities of the Amazonas state was demonstrated, in spite of the coverage birth dose of hepatitis B vaccine reported in Colombia (>80%).…”

Section: Discussionmentioning

confidence: 99%

Characterization of hepatitis B virus in Amerindian children and mothers from Amazonas State, Colombia

Jaramillo

Hoz²,

Porras³

et al. 2017

PLoS ONE

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BackgroundHepatitis B Virus (HBV) infection is a worldwide public health problem. In the 1980’s a highly effective and safe vaccine against HBV was developed, although breakthrough infection still occasionally occurs because of the emergence of escape mutants. The aim of this study was to identify HBV genotypes and escape mutants in children and their mothers in Amerindian communities of the Amazonas State, Southern Colombia.MethodsBlood specimens collected from children and mothers belonging to 37 Amerindian communities in Amazonas state, were screened for HBsAg and anti-HBc using ELISA. The partial region containing the S ORF was amplified by nested PCR, and amplicons were sequenced. The phylogenetic analysis was performed using the MEGA 5.05 software.ResultsForty-six children (46/1275, 3.6%) and one hundred and seventy-seven mothers (177/572, 30.9%) were tested positive for the anti-HBc serological marker. Among them, 190 samples were tested for viral genome detection; 8.3% (2/31) serum samples obtained from children and 3.1% (5/159) from mothers were positive for the ORF S PCR. The predominant HBV genotype in the study population was F, subgenotype F1b; in addition, subgenotype F1a and genotype A were also characterized. Two HBV escape mutants were identified, G145R, reported worldwide, and W156*; this stop codon was identified in a child with occult HBV infection. Other mutations were found, L109R and G130E, located in critical positions of the HBsAg sequence.ConclusionsThis study aimed to characterize the HBV genotype F, subgenotypes F1b and F1a, and genotype A in Amerindian communities and for the first time escape mutants in Colombia. Further investigations are necessary to elucidate the frequency and the epidemiological impact of the escape mutants in the country.

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“…More than 70% of people living in rural areas are infected with hepatitis B virus (HBV) and more than 5% carry surface antigen (HBsAg). Infection with hepatitis D virus (HDV) is also common (Gayotto 1991; de la Hoz et al. 1992).…”

Section: Introductionmentioning

confidence: 99%

Vaccine coverage with hepatitis B and other vaccines in the Colombian Amazon: do health worker knowledge and perception influence coverage?

Hoz

Pérez

Wheeler

et al. 2005

Tropical Med Int Health

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Factores de riesgo en la transmisión de la hepatitis B en la Amazonía colombiana

Cited by 11 publications

References 0 publications

Hepatitis B (HBV), Hepatitis C (HCV) and Hepatitis Delta (HDV) Viruses in the Colombian Population—How Is the Epidemiological Situation?

Hepatitis B (HBV), Hepatitis C (HCV) and Hepatitis Delta (HDV) Viruses in the Colombian Population—How Is the Epidemiological Situation?

Characterization of hepatitis B virus in Amerindian children and mothers from Amazonas State, Colombia

Vaccine coverage with hepatitis B and other vaccines in the Colombian Amazon: do health worker knowledge and perception influence coverage?

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