Factores de riesgo asociados a los tumores neonatales. Experiencia de una unidad de salud medioambiental pediátrica (PEHSU-Valencia)

Tornero, O Berbel; Tortajada, Josep Ferrís i; Colomer, J; García, José González; Miralles, Amparo

doi:10.1157/13087871

Cited by 5 publications

(2 citation statements)

References 58 publications

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“…Los afectados de síndrome de Down (10-20 veces mayor riesgo de desarrollar leucemia), y los que presentan alteraciones del SNC o de las vías urinarias, son los que más riesgo presentan 11,25,29,31,32,36 . Existe una escasa repercusión de los factores ambientales tras el nacimiento, aunque sí que existen factores intrauterinos involucrados de exposición ambiental (radiaciones ionizantes, radionúclidos, fármacos, tóxicos o infecciones) y de transmisión transplacentaria (leucemia y melanoma neonatal de origen materno) 1,9,[37][38][39] . Nuestra serie tiene las peculiaridades de carecer de retinoblastomas, como prototipo de tumor congénito 1,13 y de presentar un porcentaje de asociación a malformaciones congénitas ligeramente inferior (12,5 %) a otras.…”

Section: Discussionunclassified

Neoplasias neonatales: experiencia de un centro

Almaraz

Álvarez

Luís

et al. 2006

Anales de Pediatría

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Section: Discussionunclassified

Neoplasias neonatales: experiencia de un centro

Almaraz

Álvarez

Luís

et al. 2006

Anales de Pediatría

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“…Marijuana is the most used illicit drug worldwide, and millions of people are exposed to it annually. Different studies have suggested that a direct relationship between marijuana consumption and increased risk to certain types of cancer exists, such as neonatal tumors of the soft tissues or acute myeloid leukemias in the progeny (1)(2)(3). Among young individuals, marijuana use has been linked to head and neck cancer; as well as to testicular and lung cancers (4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Genotoxicity of Marijuana in Mono-Users

et al. 2021

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Marijuana (Cannabis sp.) is among the most recurred controlled substances in the world, and there is a growing tendency to legalize its possession and use; however, the genotoxic effects of marijuana remain under debate. A clear definition of marijuana's genotoxic effects remains obscure by the simultaneous consumption of tobacco and other recreational substances. In order to assess the genotoxic effects of marijuana and to prevent the bias caused by the use of substances other than cannabis, we recruited marijuana users that were sub-divided into three categories: (1) users of marijuana-only (M), (2) users of marijuana and tobacco (M+T), and (3) users of marijuana plus other recreative substances or illicit drugs (M+O), all the groups were compared against a non-user control group. We quantified DNA damage by detection of γH2AX levels and quantification of micronuclei (MN), one of the best-established methods for measuring chromosomal DNA damage. We found increased levels of γH2AX in peripheral blood lymphocytes from the M and M+T groups, and increased levels of MNs in cultures from M+T group. Our results suggest a DNA damage increment for M and M+T groups but the extent of chromosomal damage (revealed here by the presence of MNs and NBuds) might be related to the compounds found in tobacco. We also observed an elevated nuclear division index in all marijuana users in comparison to the control group suggesting a cytostatic dysregulation caused by cannabis use. Our study is the first in Mexico to assess the genotoxicity of marijuana in mono-users and in combination with other illicit drugs.

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First contact physicians and retinoblastoma in Mexico

Leal-Leal¹,

Dilliz-Nava²,

Flores-Rojo³

et al. 2011

Pediatric Blood & Cancer

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Background Early detection and timely referral are keys to improve survival in patients with retinoblastoma (Rb). In México, one of the main obstacles for an early diagnosis is the lack of knowledge of the disease. The objective of this study was to evaluate Rb comprehension in students in their last year of medical school. Procedure A questionnaire was completed by 791 students from 12 universities. Descriptive statistics from the population were obtained and every answer to each question was analyzed. Results Only 3.3% of the students got a proficiency grade. Less than 50% diagnosed Rb when an image was shown. Conclusions The students evaluated do not have the knowledge to detect the disease. It is necessary to develop continuous educational programs for first contact physicians. Pediatr Blood Cancer 2011; 57: 1109–1112. © 2011 Wiley Periodicals, Inc.

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Factores de riesgo asociados a los tumores neonatales. Experiencia de una unidad de salud medioambiental pediátrica (PEHSU-Valencia)

Cited by 5 publications

References 58 publications

Neoplasias neonatales: experiencia de un centro

Neoplasias neonatales: experiencia de un centro

Genotoxicity of Marijuana in Mono-Users

First contact physicians and retinoblastoma in Mexico

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