Factores asociados a remisión sostenida en pacientes con artritis reumatoide

Martire, María Victoria; Claverie, Lucila Marino; Duarte, Vanesa; Secco, Anastasia; Mammani, Marta

doi:10.1016/j.reuma.2014.09.001

Cited by 4 publications

(1 citation statement)

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“…Similar findings were found for achieving 9 or 12 months of sustained remission. These results are congruent with previous research, because known predictive factors for reaching sustained remission are earlier time to remission, lower baseline disease activity, mild disability, lower TJC, and less pain [40, 41]. The nociceptive pain patients in the current study met all of these features (only time to remission was unknown) and had notably higher chances of achieving six or more months of sustained remission.…”

Section: Discussionsupporting

confidence: 91%

Association between pain phenotype and disease activity in rheumatoid arthritis patients: a non-interventional, longitudinal cohort study

2019

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BackgroundIn well-controlled rheumatoid arthritis (RA) without significant joint damage, a substantial proportion of patients complain of persistent pain. Previous studies have identified different pain phenotypes in RA, in which non-nociceptive pain phenotypes are associated with higher concurrent disease activity scores. In this longitudinal study, we explored associations between pain phenotypes and long-term disease activity outcome in RA patients. Secondly, we explored whether pain phenotype is associated with comorbid conditions.MethodsOne hundred eighty established RA patients were classified with a nociceptive (61%) or a non-nociceptive (39%) pain phenotype, based on their responses to the painDETECT-questionnaire. Two years of clinical follow-up data on disease activity outcomes were collected. Information on comorbid diseases was derived from electronic patient files.ResultsPatients with a non-nociceptive pain phenotype showed higher mean disease activity scores (DAS28, 2.57; 95% CI, 2.37–2.77 vs. 2.11; 95% CI, 1.94–2.27; p < 0.001) and a twofold lower chance of achieving sustained DAS28 remission (OR = 0.49; 95% CI, 0.26–0.92; p = 0.020). Only the tender joint count and patient global health significantly differed between the pain phenotype groups. Patients with a non-nociceptive pain phenotype had more often been diagnosed with concurrent fibromyalgia (9.9% vs. 0.9%; p = 0.007) and other pain-associated comorbid diseases (52.1% vs. 35.8%; p = 0.030) compared with patients with a nociceptive pain phenotype.ConclusionThis longitudinal study showed consistently worse long-term disease activity outcomes in RA patients with a non-nociceptive pain phenotype which appeared to be mainly due to differences in the subjective components of the disease activity score.Trial registrationThe DREAM cohort study is registered in the Netherlands Trial Register: NTR578.

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Section: Discussionsupporting

confidence: 91%