Factor XIII Therapy of Anastomotic Leak, and Circulating Growth Factors

Fujita, Itsuo; Kiyama, Teruo; Mizutani, Takashi; Okuda, Takeshi; Yoshiyuki, Toshiro; Tokunaga, Akira; Tajiri, Takashi

doi:10.1272/jnms.73.18

Cited by 6 publications

(6 citation statements)

References 19 publications

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“…In line with the role of FXIII in limiting the spread of invading bacteria and promoting wound healing, FXIII levels were reduced in patients with post-operative non-healing fistulae or anastomotic leaks [20,24,61].…”

Section: Refractory Wounds and Fistulaementioning

confidence: 74%

“…S1). The authors reviewed all 97 resulting articles to identify 18 papers (Table 2) [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35].…”

Section: Literature Searchmentioning

confidence: 99%

“…Furthermore, the use of FXIII concentrate has been shown to be beneficial for the treatment of post-operative wounds [20,24,61], as well as serious skin infections [62]. Thus, in a study evaluating FXIII treatment for postoperative, refractory wounds, improvements occurred in patients with FXIII levels > 70% while deterioration was observed in those with FXIII levels < 50% [24].…”

Section: Refractory Wounds and Fistulaementioning

confidence: 99%

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The impact of acquired coagulation factor XIII deficiency in traumatic bleeding and wound healing

et al. 2022

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Factor XIII (FXIII) is a protein involved in blood clot stabilisation which also plays an important role in processes including trauma, wound healing, tissue repair, pregnancy, and even bone metabolism. Following surgery, low FXIII levels have been observed in patients with peri-operative blood loss and FXIII administration in those patients was associated with reduced blood transfusions. Furthermore, in patients with low FXIII levels, FXIII supplementation reduced the incidence of post-operative complications including disturbed wound healing. Increasing awareness of potentially low FXIII levels in specific patient populations could help identify patients with acquired FXIII deficiency; although opinions and protocols vary, a cut-off for FXIII activity of ~ 60–70% may be appropriate to diagnose acquired FXIII deficiency and guide supplementation. This narrative review discusses altered FXIII levels in trauma, surgery and wound healing, diagnostic approaches to detect FXIII deficiency and clinical guidance for the treatment of acquired FXIII deficiency.

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Section: Refractory Wounds and Fistulaementioning

confidence: 74%

“…S1). The authors reviewed all 97 resulting articles to identify 18 papers (Table 2) [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35].…”

Section: Literature Searchmentioning

confidence: 99%

Section: Refractory Wounds and Fistulaementioning

confidence: 99%

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The impact of acquired coagulation factor XIII deficiency in traumatic bleeding and wound healing

et al. 2022

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“…Dynamics of coagulation factor XIII activity after video-assisted thoracoscopic lobectomy for non-small cell lung cancer Blood coagulation factor XIII (FXIII) is not only a key factor that functions at the end of the coagulation cascade, but it also plays an important role in wound healing, making cross-linking fibrin monomers into stable polymers and counteracting fibrinolytic degradation (10). Administration of exogenous FXIII concentrate reportedly aids wound healing (11)(12)(13)(14) and intestinal anastomosis leakage after gastrointestinal surgery (15,16). Moreover, Inoue et al (17) reported that FXIII was not only an important factor for prolonged air leakage after pulmonary resection but also that exogenous FXIII helped to treat the air leak.…”

Section: Original Articlementioning

confidence: 99%

Dynamics of coagulation factor XIII activity after video-assisted thoracoscopic lobectomy for non-small cell lung cancer

et al. 2019

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Background: The present study was performed to investigate the perioperative dynamics of coagulation factor XIII (FXIII) in patients with non-small cell lung cancer undergoing video-assisted thoracoscopic surgery (VATS) lobectomy compared with open lobectomy. Methods: Perioperative coagulation factors including FXIII were analyzed in 30 patients who underwent VATS lobectomy and 10 patients who underwent open lobectomy at Teikyo University Hospital from December 2017 to April 2019. Results: Patients in the VATS lobectomy group showed higher FXIII activity on postoperative day (POD) 5 than patients in the open lobectomy group (P=0.028). The FXIII activity was significantly lower on POD3, POD5, and POD7 than that in the preoperative period and on POD1, even in patients who had undergone VATS lobectomy (P<0.001). No factors were found to affect the maintenance of FXIII in the VATS lobectomy group. Conclusion: The postoperative decrease of FXIII activity differed between patients who underwent VATS lobectomy and those who underwent open lobectomy. Based on the characteristics of FXIII, the FXIII activity may be a good marker of the invasiveness of VATS lobectomy versus open lobectomy.

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“…Fujita et al reported that FXIII activity in patients with anastomotic leaks and non-healing fistulae after gastrointestinal surgery were below the normal. They concluded that systemic administration of FXIII might accelerate wound healing by increasing circulating growth factors, such as epidermal growth factor and transforming growth factor β, which play a role in proliferation of fibroblasts 6 10. Freeze-dried blood coagulation FXIII, derived from human plasma, is available for patients with decreased FXIII activity to potentially support and promote wound healing.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of administration of coagulation factor XIII with definitive surgery for multiple intractable enterocutaneous fistulae in a patient with decreased factor XIII activity

Saigusa

Yamamura²,

Ohi³

et al. 2011

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Factor XIII Therapy of Anastomotic Leak, and Circulating Growth Factors

Cited by 6 publications

References 19 publications

The impact of acquired coagulation factor XIII deficiency in traumatic bleeding and wound healing

The impact of acquired coagulation factor XIII deficiency in traumatic bleeding and wound healing

Dynamics of coagulation factor XIII activity after video-assisted thoracoscopic lobectomy for non-small cell lung cancer

Efficacy of administration of coagulation factor XIII with definitive surgery for multiple intractable enterocutaneous fistulae in a patient with decreased factor XIII activity

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