Factor XIII Gene Polymorphisms among Sudanese Patients with Intracerebral Hemorrhage, Khartoum State 2022

Abstract

Background: Intracerebral hemorrhage (ICH) is a sudden bleeding into the tissues of the brain, into its ventricles, or into both. It is the second most common subtype of stroke and is a critical disease usually leading to severe disability or death.
 Material and method: This study was a cross sectional hospital-based study, conducted at the research laboratory of the national center of neurological sciences (NCNS), Khartoum, Sudan during the period June 2022 to August 2022.It included all patients attended with intracerebral hemorrhage. DNA extraction was done from blood of all patients and control. PCR for factor XIII gene was carried out and thus Sanger sequencing to both cases and controls.
 Results: The PCR results showed; 100% samples were positive for factor XIII gene.Sequencing result showed the detection of threepolymorphisms in factor XIII gene (G>T, A>G and C>T) .
 Conclusion: The detected factor XIII gene polymorphisms (G>T, A>G and C>T) might be associated with intercereberal hemorrhage among Sudanese patients.
 Keywords: Factor XIII, gene, polymorphism, hemorrhage, stroke, cerebrovascular