Factor XII (Hageman) deficiency in women with habitual abortion: new subpopulation of recurrent aborters?

Braulke, I.; Pruggmayer, M.; Melloh, Peter; Hinney, B.; Köstering, H.; Günther, Eberhard

doi:10.1016/s0015-0282(16)55622-2

Cited by 52 publications

(40 citation statements)

References 18 publications

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“…These data are not consistent with our own results and other earlier reports [7,18,19]. The reason for these inconsistent results remains obscure.…”

Section: Discussioncontrasting

confidence: 99%

Recurrent Pregnancy Loss and Its Relation to FV Leiden, FII G20210A and Polymorphisms of Plasminogen Activator and Plasminogen Activator Inhibitor

Wolf

Haubelt

Pauer

et al. 2003

Pathophysiol Haemos Thromb

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Thrombophilic disorders and hypofibrinolysis were demonstrated to be risk factors in a majority of women with recurrent pregnancy loss (RPL) and infertility. We investigated the association of FV G1691A mutation, F II G20210A gene polymorphism (PM), 4G/5G PAI-1 and Alu I/D tPA PM in 32 women with infertility and 49 women with at least 2 unexplained early abortions. FV Leiden mutation was significantly more common in women with RPL (10%, p = 0.02) and infertility (19%, p = 0.0005) compared with controls (2%). PAI-1 4G PM and t-PA Alu I PM, alone or in combination, were not associated with RPL or infertility. 9/49 women with RPL showed coagulation disorders with heterozygous FV Leiden mutation (5), FXII (1), protein C (1) or protein S (2) deficiency. However, due to the small number of patients studied, no definite conclusion can be drawn.

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“…These data are not consistent with our own results and other earlier reports [7,18,19]. The reason for these inconsistent results remains obscure.…”

Section: Discussioncontrasting

confidence: 99%

Recurrent Pregnancy Loss and Its Relation to FV Leiden, FII G20210A and Polymorphisms of Plasminogen Activator and Plasminogen Activator Inhibitor

Wolf

Haubelt

Pauer

et al. 2003

Pathophysiol Haemos Thromb

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“…In their study, FXII deficiency and hypofibrinolysis were found to be the most frequent hemostasis-related abnormalities in unexplained primary recurrent aborters, whereas von Willebrand disease, fibrinogen deficiency, ATIII, PC and PS deficiencies were not frequently detected compared with controls. A German group also described the association of early recurrent msicarriages with FXII deficiency (FXII activity ranges 35-68%) at a high frequency (21.6%) [19]. In the current study, we found 7 women with an isolated FXII deficiency in a total of 241 women with a history of recurrent miscarriages (2.9%) and in 137 women with unexplained recurrent miscarriages (5.1%).…”

Section: Discussionsupporting

confidence: 64%

“…Only limited cases have been reported regarding the relation between FXII deficiency and recurrent miscar-riage [18,19]. One report described the high frequency (21.6%) of FXII deficiency in women with a history of recurrent miscarriage [19].…”

Section: Introductionmentioning

confidence: 99%

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Factor XII Deficiency in Women with Recurrent Miscarriage

Yamada

Kato²,

Ebina³

et al. 2000

Gynecol Obstet Invest

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Congenital thrombophilia is known to cause significant maternal complications, and possibly has an adverse effect on normal fetal development. The aim of this study was to assess the prevalence of factor XII (FXII) deficiency in women with a history of recurrent miscarriage. Two hundred and forty-one consecutive Japanese women with a history of two or more recurrent miscarriages were prospectively assessed for their etiology by conventional screening methods. Seven women were found to have reduced FXII activity (19.2–46.1%) and prolonged activated partial thromboplastin time (33.3–51.3 s). Of these 7 women, 6 had experienced early pregnancy losses, while 1 woman had experienced repeated mid-trimester fetal losses with coincidental gestational thrombocytopenia. In 241 women with a history of recurrent miscarriage, the prevalence of FXII deficiency was 2.9%.

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“…Targeted disruption of the HGF gene has been shown to lead to abnormal embryonic development and increased embryonic mortality [9]. This function may be of importance as FXII deficiency has been reported to be associated with RFL [10,11].…”

mentioning

confidence: 99%

More on: pathogenic antibodies to coagulation factors. Part II: fibrinogen, prothrombin, thrombin, factor V, factor XI, factor XII, factor XIII, protein C and von Willebrand factor

Jones

Gallimore

Winter

2006

Journal of Thrombosis and Haemostasis

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of whether failure to exhibit inhibition in the confirmatory procedure really excludes the presence of platelet-activating anti-PF4/heparin antibodies. As only one (1.0%) patient in the study developed clinical HIT [3], the positive predictive value of the commercial EIA was only marginally improved by using the high heparin confirmatory procedure (from 1.41% to 1.45%).We conclude that inclusion of the high heparin confirmatory procedure in the commercial EIA does little to improve diagnostic specificity, at least in a postcardiac surgery setting in which anti-PF4/polyanion antibodies are frequently generated. Rather, the routine inclusion of this test maneuver will either double test costs (by requiring that each assay be performed both in the absence and presence of high heparin) or will delay the reporting of a positive test result, in case an algorithm is used in which a tentative positive assay result is subsequently ÔconfirmedÕ by repeating the test in the absence and presence of high heparin. We read with interest the recent review article by Lollar [1]. In this review -referring to factor XII (FXII) -Lollar states that Ôclinically significant antibodies to other coagulation factors are sufficiently rare that they merit case reports onlyÕ and that Ôasymptomatic patients with inhibitory auto-antibodies to FXII have been describedÕ. References

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Factor XII (Hageman) deficiency in women with habitual abortion: new subpopulation of recurrent aborters?

Cited by 52 publications

References 18 publications

Recurrent Pregnancy Loss and Its Relation to FV Leiden, FII G20210A and Polymorphisms of Plasminogen Activator and Plasminogen Activator Inhibitor

Recurrent Pregnancy Loss and Its Relation to FV Leiden, FII G20210A and Polymorphisms of Plasminogen Activator and Plasminogen Activator Inhibitor

Factor XII Deficiency in Women with Recurrent Miscarriage

More on: pathogenic antibodies to coagulation factors. Part II: fibrinogen, prothrombin, thrombin, factor V, factor XI, factor XII, factor XIII, protein C and von Willebrand factor

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