Factor XII deficiency is strongly associated with primary recurrent abortions

Pauer, Hans-Ulrich; Burfeind, Peter; Köstering, H.; Emons, Günter; Hinney, B.

doi:10.1016/s0015-0282(03)00788-x

Cited by 57 publications

(53 citation statements)

References 32 publications

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“…A systematic review concluded that FXII deficiency is associated with RM [22]. Pauer et al reported that 10 of 67 women with primary recurrent abortion (14.9%) and 4 of 33 women (12.1%) with secondary recurrent abortion had reduced factor XII activity (,60%), while all controls had normal FXII activity [23]. However, they checked for only anticardiolipin antibody, and not LA.…”

Section: Discussionmentioning

confidence: 99%

Genotyping analysis for the 46C/T polymorphism of coagulation factor XII and the involvement of factor XII activity in patients with recurrent pregnancy loss

Hashimoto¹,

Ebara²,

Yamada‐Namikawa³

et al. 2014

Journal of Reproductive Immunology

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Background: Established causes of recurrent pregnancy loss (RPL) include antiphospholipid syndrome, uterine anomalies, parental chromosomal abnormalities, particularly translocations and abnormal embryonic karyotype. A systematic review concluded that coagulation factor XII (FXII) deficiency was associated with RPL. However, it could not be established whether the 46 C/T SNP of FXII or low activity of FXII was a risk factor for RPL, because of the small sample size. Methods and Findings: We conducted a cross-sectional and cohort study in 279 patients with two or more unexplained consecutive pregnancy losses and 100 fertile women. The association between the lupus anticoagulant (LA) activity and FXII activity was examined. The frequency of the CC, CT and TT genotypes and the FXII activity were also compared between the patients and controls. Subsequent miscarriage rates among the CC, CT, TT genotypes and according to the FXII activity was examined. LA was associated with reduced FXII activity. The CT, but not the TT, genotype was confirmed to be a risk factor for RPL in the cross-sectional study using multivariate logistic regression analysis (OR, 2.8; 95% CI, 1.37-5.85). The plasma FXII activity in the patients was similar to that in the controls. Neither low FXII activity nor the CT genotype predicted the subsequent pregnancy outcome in the cohort study. On the other hand, and intermediate FXII activity level of 85-101% was predictive of subsequent miscarriage.

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Section: Discussionmentioning

confidence: 99%

Genotyping analysis for the 46C/T polymorphism of coagulation factor XII and the involvement of factor XII activity in patients with recurrent pregnancy loss

Hashimoto¹,

Ebara²,

Yamada‐Namikawa³

et al. 2014

Journal of Reproductive Immunology

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“…Tromboz ve gebelik kaybına neden olan yeni tanımlanmış diğer bir patoloji ise faktör 12 eksikliğidir 15 . Daha az sıklıkta görülen diğer bir mutasyonda da tromboz için bilinen bağımsız bir risk faktörü olan hiperhomosisteinemiye eğilim olmaktadır 16 .…”

Section: Koagülasyon Sistemi Bozukluklarıunclassified

Approach to Recurrent Early Pregnancy Loss

Deniz¹,

Baykuş²,

Kavak³

2016

Kafkas J Med Sci

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Abortus is the most common complication of pregnancy. Recurrent pregnancy lost is the termination of the sequential termination of GirişErken gebelik kayıpları kadın hayatının en uzun döne-mi olan reprodüktif döneminin sık karşılaşılan problemlerinden biridir. Abortus gebeliğin en sık görülen komplikasyonu olup suprapubik ağrı ve uterin kramplarla ortaya çıkan vajinal kanama ile beraber gebeliğin uterustan atılması, gebeliğe dair bulgu ve semptomların kaybolması olarak tariflenir 1 . Dünya sağlık örgütü ise gebelik ürününün ağırlığı ve gebelik süreci kriter alınarak, 20. gebelik haftasından önce, 500 gramın altındaki embriyo veya fetüs ve eklerinin tamamının ya da bir kısmının uterustan atılması durumunu abortus olarak tariflenmiştir 2 . On ikinci gebelik haftasına kadar olan abortuslar erken abortus, 12.-20. gebelik haftaları arasında olan abortuslar ise geç abortus olarak adlandırılmaktadır.Geniş bir yelpazeye sahip olan spontan abortus insidansı %15-40 civarındadır. Spontan abortusların %62 si 12. gebelik haftasından önce görülmektedir.

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“…We choose our patients based on criteria established recently (Poul, 2006). On the other hand, the likelihood of detecting thrombophilia increases in patients suffering from idiopathic thromboembolic attacks before 45 years of age, patients suffering from recurrent thromboembolia, those with thrombosis in an uncommon location, patients with arterial thrombosis before the age of 35 (Tanis et al, 2003), those with a family history of thromboembolic disease and women suffering from recurrent complications during pregnancy (Yamada et al, 2001;Pauer et al, 2003).…”

Section: Thrombophiliamentioning

confidence: 99%

Heparin and its derivatives in the treatment of arterial thrombosis: a review

Dvořák¹,

Vlašín²,

Dvorakova³

et al. 2010

Vet. Med. - Czech

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Arterial occlusion due to thrombosis caused by ruptured atherosclerotic plaques (Baba et al., 1975) has been recognized as a major cause of morbidity and mortality in western populations. Thrombosis may occur in various sections of arterial circulation, peripheral arteries of the limbs, coronary arteries, brain arteries, or both major and minor vessels within the abdominal cavity. The ultimate consequence is varying degrees of organ failure, mostly of ischemic origin. Arterial thrombosis represents a continuous problem, debilitating patients and decreasing their quality of life. Moreover, along with chronic heart failure, it can significantly decrease patient life expectancy. Arterial thrombosis results in ischemia, with serious systemic consequences, such as metabolic breakdown. The major goal of treatment remains fast and efficient recanalization -surgical, interventional or thrombolytic. To be able to prevent acute reocclusion with severe consequences (rhabdomyolysis, compartment syndrome, excessive tissue necrosis leading to limb amputation, etc.), several adjunctive treatment regimens have been advocated. Among others, thrombin inhibitors and platelet inhibitors have been widely used for both prophylaxis and adjunctive treatment. Direct thrombin inhibitors and antithrombin stimulators have been recognized as typical antithrombotic drugs. Direct (antithrombin-independent) thrombin inhibitors can be divided into two main categories: monovalent, active site inhibitors (argatroban, efegatran, inovastan, melagatran) and bivalent (hirudin, hirugen, hirulog, bivalirudin), while antithrombin stimulators represent standard (unfractionated) heparin (UFH) and its depolymerizing products -low molecular weight heparins (LMWH's). Recently, a clear change in the main use of heparin, as well as low-molecular weight heparins has been advocated representing a shift from treatment and prophylaxis of deep vein thrombosis to prophylaxis of thromboembolic disease following vascular, cardiovascular or orthopedic surgery, treatment of unstable angina and prevention of acute myocardial infarction. The main effect of heparins lies in their anticoagulant activity. Heparins are involved in different pathways of the coagulation cascade with anticoagulant, antithrombotic, profibrinolytic, anti-aggregative, as well as anti-inflammatory effects. Moreover, there is a little doubt about their anti-proliferative and anti-ischemic activity (Penka and Bulikova, 2006). Unlike standard heparin, low-molecular weight heparins do not affect the patient's general coagulation profile. Obviously, the difference in molecular weight results in different pharmacokinetic and pharmacodynamic properties of the agents.Key words: coagulation; arterial thrombosis; standard heparin; low-molecular weight heparins List of abbreviations ABI = axillary/...index, t-PA = tissue-type plasminogen activator, ADP = adenosin diphosphate, AG = angiography, AMI = acute myocardial infarction, APSAC = acylated plasminogen streptokinase activator complex, APTT = acti...

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Factor XII deficiency is strongly associated with primary recurrent abortions

Cited by 57 publications

References 32 publications

Genotyping analysis for the 46C/T polymorphism of coagulation factor XII and the involvement of factor XII activity in patients with recurrent pregnancy loss

Genotyping analysis for the 46C/T polymorphism of coagulation factor XII and the involvement of factor XII activity in patients with recurrent pregnancy loss

Approach to Recurrent Early Pregnancy Loss

Heparin and its derivatives in the treatment of arterial thrombosis: a review

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