Factor XII deficiency evaluated by thrombin generation assay

Feugray, Guillaume; Kasonga, Fiston; Chamouni, Pierre; Barbay, Virginie; Fresel, Marielle; Chrétien, Marie Hélène; Brunel, Sabine; Billoir, Paul

doi:10.1016/j.clinbiochem.2021.11.014

Cited by 2 publications

(2 citation statements)

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“…The thrombin generation assay (TGA) is an increasingly used laboratory test that provides a reliable hemostatic profile and a high association with bleeding phenotype [ 19 , 20 , 21 ]. A previous study demonstrated a global decrease in thrombin generation in UFH [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Anticoagulation Monitoring with Activated Partial ThromboPlastin Time and Anti-Xa Activity in Intensive Care Unit Patients: Interest of Thrombin Generation Assay

Billoir

Elie

Levy

et al. 2022

IJMS

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Current guidelines recommend monitoring the anticoagulant effect of unfractionated heparin (UFH) by measuring anti-Xa activity rather than activated partial thromboplastin time (aPTT) in intensive care unit (ICU) patients. The primary objective of this study was to evaluate the correlation of aPTT, anti-Xa activity, and thrombin generation in UFH-treated ICU patients. A prospective observational pilot study was conducted in adult surgical ICU patients treated with UFH. aPTT and anti-Xa activity were monitored daily. The therapeutic target was aPTT between 50 s and 84 s, and/or anti-Xa between 0.3 and 0.7 U/mL. Correlation among aPTT, anti-Xa activity, and thrombin generation was determined by measuring endogenous thrombin potential (ETP), with the inflammatory response evaluated. C-reactive protein (CRP) was used as a marker of inflammatory response. The plasma of 107 samples from 30 ICU patients was analyzed. The correlation between aPTT and anti-Xa activity was 0.66, CI95% [0.54;0.76] (p < 0.0001). Although thrombin generation, aPTT, and anti-Xa were correlated with inflammatory responses, the correlation was higher with thrombin generation and anti-Xa activity compared to aPTT. When aPTT was in a therapeutic range, a low thrombin generation was observed but was 50% inhibited when anti-Xa was in a therapeutic range. Coagulation testing with aPTT, anti-Xa correlated with thrombin generation. A 50% decrease in thrombin generation was observed when anti-Xa was within a therapeutic range. Further work is needed to evaluate coagulation biomarker responses and clinical outcomes in specific ICU populations.

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Section: Discussionmentioning

confidence: 99%

Anticoagulation Monitoring with Activated Partial ThromboPlastin Time and Anti-Xa Activity in Intensive Care Unit Patients: Interest of Thrombin Generation Assay

Billoir

Elie

Levy

et al. 2022

IJMS

Self Cite

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show abstract

“…No study has yet evaluated the association of D-dimer with CVST clinical manifestations. Besides, thrombin generation (TG) has been proposed as a global assay to evidence hypocoagulable [ 10 , 11 ] and hypercoagulable states [ [12] , [13] , [14] ]: increased TG is an independent predictor of recurrent venous thrombosis [ 15 ]. Inflammation biomarkers, such as fibrinogen and high-sensitivity C-reactive protein (hs-CRP), have been recently described as possible predictors of poor prognosis in CVST [ 16 ].…”

Section: Introductionmentioning

confidence: 99%