Factor XII deficiency: A thrombophilic risk factor for retinal vein occlusion

Kuhli, Claudia; Scharrer, I.; Koch, Frank; Ohrloff, C.; Hattenbach, Lars‐Olof

doi:10.1016/j.ajo.2003.10.024

Cited by 58 publications

(39 citation statements)

References 29 publications

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“…All tests for thrombophilic disorders were performed using standard laboratory techniques as previously reported [14][15][16]. If laboratory results were abnormal, testing was repeated at follow-up at 3 months, 6 months, and 12 months.…”

Section: Methodsmentioning

confidence: 99%

Selective thrombophilia screening of patients with nonarteritic anterior ischemic optic neuropathy

Kuhli-Hattenbach

Scharrer

Lüchtenberg

et al. 2008

Graefes Arch Clin Exp Ophthalmol

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Section: Methodsmentioning

confidence: 99%

Selective thrombophilia screening of patients with nonarteritic anterior ischemic optic neuropathy

Kuhli-Hattenbach

Scharrer

Lüchtenberg

et al. 2008

Graefes Arch Clin Exp Ophthalmol

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“…A high prevalence of factor XII deficiency has been observed in young patients with retinal vein occlusion [4] and some case reports showed the association between this defect and unusual sites of thrombosis [5].…”

Section: Introductionmentioning

confidence: 99%

Deep venous thrombosis and previous myocardial infarction in mild factor XII deficiency: a risk factor for both venous and arterial thrombosis

Lessiani¹,

Falco²,

Nicolucci³

et al. 2008

J Thromb Thrombolysis

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Factor XII deficiency is associated with increased risk for both arterial and venous thrombosis. We describe a case of DVT involving superficial femoral and popliteal vein occurred following total hip replacement and despite prophylaxis with low molecular weight heparin in a subject with previous acute myocardial infarction (AMI). Tests of haemostasis documented a slightly prolonged activated partial thromboplastin time (APTT) (45'') due to mild factor XII deficiency (clotting activity 32%). A therapeutic dose of enoxaparin was started, together with warfarin therapy. The patient was advised to continue oral anticoagulation indefinitely. Although cases of both venous and arterial thrombosis in carriers of severe factor XII deficiency have been already reported, to our knowledge this is the first case in the literature occurred in a carrier of partial factor XII deficiency. In conclusion, factor XII deficiency should be suspected if a patient presents with recurrent arterial and/or venous thrombosis and prolonged APTT. If this defect is diagnosed, in the presence of a history of thrombotic events, lifelong anticoagulation could be considered.

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“…A hypercoagulable state in sickle cell disease and betathalassemia is well documented [1,2]. Factor V (FV) Leiden is the largest inherited risk factor of venous thrombosis [3].…”

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confidence: 99%

“…The observation that FXII is also involved in the activation of the fibrinolytic system led to the hypothesis that partial or severe FXII deficiency might result in impaired fibrinolysis and as a consequence in a thrombotic tendency. Indeed, a high frequency (9-15%) of reduced plasma FXII levels was found among patients with (venous) thrombosis [1,2] and women with recurrent miscarriages [3], a condition often associated with a thrombophilic state. However, Koster et al…”

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confidence: 99%

The 46C→T polymorphism in the factor XII gene (F12) and the risk of venous thrombosis

Bertina

Poort

Vos

et al. 2005

Journal of Thrombosis and Haemostasis

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The 46CfiT polymorphism in the factor XII gene (F12) and the risk of venous thrombosis The precise role of factor XII (FXII) in the regulation of blood coagulation and fibrinolysis is still undefined. Activation of FXII initiates both the kinin-forming cascade and the intrinsic coagulation and fibrinolytic pathways. Subjects with severe FXII deficiency show a prolonged activated partial thromboplastin time but do not have a bleeding tendency, which suggests a minor role for FXII in the regulation of fibrin formation in vivo. The observation that FXII is also involved in the activation of the fibrinolytic system led to the hypothesis that partial or severe FXII deficiency might result in impaired fibrinolysis and as a consequence in a thrombotic tendency. Indeed, a high frequency (9-15%) of reduced plasma FXII levels was found among patients with (venous) thrombosis [1,2] and women with recurrent miscarriages [3], a condition often associated with a thrombophilic state. However, Koster et al. R . M . B E R T I N A , * S . R . P O O R T , * H . L . V O S * and F . R . R O S E N D

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Factor XII deficiency: A thrombophilic risk factor for retinal vein occlusion

Cited by 58 publications

References 29 publications

Selective thrombophilia screening of patients with nonarteritic anterior ischemic optic neuropathy

Selective thrombophilia screening of patients with nonarteritic anterior ischemic optic neuropathy

Deep venous thrombosis and previous myocardial infarction in mild factor XII deficiency: a risk factor for both venous and arterial thrombosis

The 46C→T polymorphism in the factor XII gene (F12) and the risk of venous thrombosis

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