Factor XII(a) inhibitors: a review of the patent literature

Kalinin, Dmitrii V.

doi:10.1080/13543776.2021.1945580

Cited by 30 publications

(23 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…XII 54.3% was slightly lower than normal. Although XII can cause prolonged APTT, XII has no risk of bleeding, which instead causes blood clots [ 14 , 15 ]. We also performed a routine blood test on the baby and found that the platelet count was normal and that haemoglobin did not decrease significantly.…”

Section: Discussionmentioning

confidence: 99%

Noonan syndrome with RAF1 gene mutations in a newborn with cerebral haemorrhage

et al. 2022

View full text Add to dashboard Cite

Background Noonan syndrome is an autosomal dominant genetic disorder that can occur in men and women and has a sporadic or family history. NS can lead to abnormal bleeding, but cerebral haemorrhage is rare. This is the first case of cerebral haemorrhage with a RAF1 gene mutation that originated in the neonatal period. Case presentation This case presents a newborn with a RAF1 gene mutation resulting in NS complicated with an abnormality of chromosome 46, X, del (Y) (q12). In the course of treatment, the baby's breathing suddenly increased. After an MRI examination of the skull, haemorrhaging was found in multiple parts of the brain. Conclusions After symptomatic treatment, the baby recovered well, but the main cause of cerebral haemorrhage was not found.

show abstract

Section: Discussionmentioning

confidence: 99%

Noonan syndrome with RAF1 gene mutations in a newborn with cerebral haemorrhage

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Complement factors are also involved in several other diseases, so that various potential therapeutics for thrombosis, sepsis, hereditary angioedema, multiple sclerosis, and/or other inflammatory diseases have now been and are being developed that target either the FXII zymogen or the active form FXIIa. Most of these are in preclinical stages and one monoclonal antibody is in an early clinical phase [129].…”

Section: Inhibition Of Coagulationmentioning

confidence: 99%

The tick and I: Parasite‐host interactions between ticks and humans

Schön

2022

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Summary Ticks, particularly hard ticks (Ixodidae), which are among the most important vectors of dangerous infectious agents, feed on their hosts for extended periods of time. With this lifestyle, numerous adaptations have evolved in ticks and their hosts, the pharmacological importance of which is increasingly being recognized. Many bioactive substances in tick saliva are being considered as the basis of new drugs. For example, components of tick cement can be developed into tissue adhesives or wound closures. Analgesic and antipruritic salivary components inhibit histamine or bradykinin, while other tick‐derived molecules bind opioid or cannabinoid receptors. Tick saliva inhibits the extrinsic, intrinsic, or common pathway of blood coagulation with implications for the treatment of thromboembolic diseases. It contains vasodilating substances and affects wound healing. The broad spectrum of immunomodulatory and immunosuppressive effects of tick saliva, such as inhibition of chemokines or cellular immune responses, allows development of drugs against inflammation in autoimmune diseases and/or infections. Finally, modern vaccines against ticks can curb the spread of serious infections. The medical importance of the complex tick‐host interactions is increasingly being recognized and translated into first clinical applications. Using selected examples, an overview of the mutual adaptations of ticks and hosts is given here, focusing on their significance to medical advance.

show abstract

“…Komplementfaktoren sind außerdem an mehreren anderen Erkrankungen beteiligt, so dass inzwischen verschiedene potenzielle Therapeutika gegen Thrombose, Sepsis, hereditäres Angioödem, multiple Sklerose und/oder andere entzündliche Erkrankungen entwickelt wurden und werden, die entweder auf das FXII‐Zymogen oder die aktive Form FXIIa abzielen. Die meisten davon befinden sich in präklinischen Stadien und ein monoklonaler Antikörper in einer frühen klinischen Phase [129].…”

Section: Gerinnungshemmungunclassified

Die Zecke und ich: Parasiten‐Wirt‐Interaktionen zwischen Zecken und Menschen

Schön

2022

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Abbildung 1 Lebenszyklus des Gemeinen Holzbocks (Ixodes ricinus). Vollgesogenes Weibchen von dorsal (a). Vollgesogenes Weibchen von ventral (b). Reifer Samen des Wunderbaumes (Ricinus communis) zum Vergleich (c). Das vollgesogene Weibchen lässt sich von seinem letzten Wirt abfallen und legt in der Streuschicht am Boden zwischen 1000 und 2000 Eier, aus denen circa 0,5 mm große Larven schlüpfen (d). Diese lauern in niedriger Vegetation auf den ersten Wirt, meist kleinere Tiere. Die Larven häuten sich zu achtbeinigen, etwa 1 mm langen Nymphen, die den zweiten Wirt befallen. Nach dem Saugakt erfolgt die zweite Häutung zur erwachsenen Zecke ebenfalls in der Streuschicht am Boden. Weibchen und Männchen kopulieren schon in der Vegetation oder auf dem letzten Wirt.

show abstract

Factor XII(a) inhibitors: a review of the patent literature

Cited by 30 publications

References 81 publications

Noonan syndrome with RAF1 gene mutations in a newborn with cerebral haemorrhage

Noonan syndrome with RAF1 gene mutations in a newborn with cerebral haemorrhage

The tick and I: Parasite‐host interactions between ticks and humans

Die Zecke und ich: Parasiten‐Wirt‐Interaktionen zwischen Zecken und Menschen

Contact Info

Product

Resources

About