Factor XI deficiency: Literature review and case presentation

Hernandez, William; Raja, Asim

doi:10.1016/s1067-2516(99)80009-x

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Factor XI (FXI) deficiency is a rare, inherited bleeding disorder (also known as hemophilia C, plasma thromboplastin antecedent deficiency or Rosenthal syndrome) that is typically asymptomatic and initially presents with unexpected bleeding after surgery or trauma. In the general population, the prevalence is exceedingly rare (1:1,000,000), but in the Ashkenazi Jewish population, the reported prevalence varies in the literature [1][2][3][4][5][6]. Approximately 1:8 individuals are heterozygous and 1:190 are homozygous for a mutation on the F11 gene, the most common gene mutation that results in FXI deficiency in this population [2].…”

Section: Introductionmentioning

confidence: 95%

Perioperative Management of Patient with Factor XI Deficiency Undergoing Total Knee Arthroplasty

Kamenetsky¹,

Afifi²

2014

J Anesth Clin Res

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Factor XI (FXI) deficiency is a rare, inherited bleeding disorder that is typically asymptomatic and presents with unexpected bleeding after surgery or trauma. We present a patient with FXI deficiency that underwent total knee arthroplasty (TKA) under general anesthesia and received peripheral nerve blocks for postoperative analgesia. We also present a review of literature focused on presentation of FXI deficiency in various surgical settings and choices of perioperative anesthetic management. J o u rn al of A n e s th es ia & C li n ic a l Resea rc h

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