Factor XI Deficiency and Obstetrical Anesthesia

Singh, Amarjeet; Harnett, Miriam; Connors, Jean M.; Camann, William

doi:10.1097/01.aoa.0000370559.52565.1a

Cited by 7 publications

(15 citation statements)

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“…Twelve studies described a total of 446 deliveries (Table 4), 5% (6/128) of these deliveries were described as assisted vaginal deliveries. Most studies [10,13,16,25,27,30,32,33,35] did not report the number of assisted vaginal deliveries. Postpartum haemorrhages (PPH) were reported in 79 out of 446 (18%) vaginal deliveries, ranging from 0 to 42% in studies with >10 deliveries.…”

Section: Obstetricsmentioning

confidence: 99%

“…In these six studies [17,22,30,32,33,35], 21% of women received prophylaxis during delivery. Three studies [17,32,35] describe which criteria were used for administering prophylaxis.…”

Section: Obstetricsmentioning

confidence: 99%

“…In these six studies [17,22,30,32,33,35], 21% of women received prophylaxis during delivery. Three studies [17,32,35] describe which criteria were used for administering prophylaxis. These criteria were a positive bleeding history [17,32,35], severe FXI deficiency [17,32] or prolonged activated partial thromboplastin time (aPTT) [35].…”

Section: Obstetricsmentioning

confidence: 99%

“…Three studies [17,32,35] describe which criteria were used for administering prophylaxis. These criteria were a positive bleeding history [17,32,35], severe FXI deficiency [17,32] or prolonged activated partial thromboplastin time (aPTT) [35]. More than half of these women had severe FXI deficiency.…”

Section: Obstetricsmentioning

confidence: 99%

“…Regional analgesia and anaesthesia. Five studies [17,18,22,27,35] described analgesia and anaesthesia during delivery. A total of 44 regional blocks were performed (see Table 6).…”

Section: Anaesthesiamentioning

confidence: 99%

See 4 more Smart Citations

Gynaecological and obstetrical bleeding in women with factor XI deficiency – a systematic review

et al. 2015

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Section: Obstetricsmentioning

confidence: 99%

“…In these six studies [17,22,30,32,33,35], 21% of women received prophylaxis during delivery. Three studies [17,32,35] describe which criteria were used for administering prophylaxis.…”

Section: Obstetricsmentioning

confidence: 99%

Section: Obstetricsmentioning

confidence: 99%

Section: Obstetricsmentioning

confidence: 99%

“…Regional analgesia and anaesthesia. Five studies [17,18,22,27,35] described analgesia and anaesthesia during delivery. A total of 44 regional blocks were performed (see Table 6).…”

Section: Anaesthesiamentioning

confidence: 99%

See 3 more Smart Citations

Gynaecological and obstetrical bleeding in women with factor XI deficiency – a systematic review

et al. 2015

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Evaluating hemostatic thresholds for neuraxial anesthesia in adults with hemorrhagic disorders and tendencies: A scoping review

Peterson

Tse

Martin

et al. 2021

Research and Practice in Thrombosis and Haemostasis

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Neuraxial anesthesia can be complicated by spinal or epidural hematoma and may result in permanent neurologic injury. There is a paucity of literature characterizing this serious complication in patients with congenital and acquired hemorrhagic disorders or tendencies. The objective of this scoping review was to describe the hemostatic laboratory parameters where neuraxial anesthesia has been administered with and without spinal and epidural hematoma in patients with preexisting hemorrhagic disorders and tendencies, including immune thrombocytopenia, gestational thrombocytopenia, thrombocytopenia associated with hypertensive disorders of pregnancy, platelet function disorders, von Willebrand disease, coagulation factor deficiencies, and fibrinogen disorders. A systematic search of Ovid MEDLINE, CINAHL, Embase, Scopus, and Web of Science was performed. Two authors independently reviewed all titles, abstracts, and full texts to determine study eligibility and extract data. Qualitative synthesis of 91 studies revealed significant gaps in our understanding of the risk of spinal and epidural hematoma in patients with hemorrhagic disorders and tendencies, including few studies of males and in nonobstetric settings. Most reviewed articles were small, retrospective studies at high risk for potential bias. With such low‐quality data, we were unable to provide any true estimates of the risk of spinal or epidural hematoma for these patients, nor could we attribute any specific hemostatic or laboratory values to increased risk of hematoma. There is a need both for larger and more rigorously designed and reported studies on this subject and for structured, comprehensive recommendations for safe administration and removal of neuraxial anesthesia in patients with hemorrhagic disorders and tendencies.

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Management of Inherited Bleeding Disorders in Pregnancy

2017

BJOG

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Factor XI Deficiency and Obstetrical Anesthesia

Cited by 7 publications

References 0 publications

Gynaecological and obstetrical bleeding in women with factor XI deficiency – a systematic review

Gynaecological and obstetrical bleeding in women with factor XI deficiency – a systematic review

Evaluating hemostatic thresholds for neuraxial anesthesia in adults with hemorrhagic disorders and tendencies: A scoping review

Management of Inherited Bleeding Disorders in Pregnancy

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