Factor VIII-Related Antigen in Kaposi's Sarcoma in Young Homosexual Men

Flotte, Thomas J.; Hatcher, Virgil A.; Friedman‐Kien, Alvin E.

doi:10.1001/archderm.1984.01650380040007

Cited by 28 publications

(10 citation statements)

References 16 publications

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“…The preeise histopathogenesis of KS with regard to the vascular component is debated. This problem partly relates to the controversies over immunohistochemical findings (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24), and partly because of subjective interpretations based upon conventional light microscopy (25)(26)(27).…”

mentioning

confidence: 99%

Expression of endothelial cell markers PAL‐E and EN‐4 and la‐antigens in Kaposi's sarcoma

Nadimi

Saatee

Armin

et al. 1988

J Oral Pathology Medicine

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Eleven biopsy specimens of Kaposi's sarcoma (KS) removed from the skin and oral mucosa were examined immunohistochemically with monoclonal antibodies PAL‐E and EN‐4, specific for human vascular endothelial cells, and with LN‐3 monoclonal antibody reactive with immune‐associated (la) antigens in the HLA‐DR locus. The early lesions of KS, corresponding to the patch phase, contained hyperplastic venules and an increased number of lymphatic capillaries. The lymphatic capillary endothelium was reactive with EN‐4, whereas, PAL‐E reacted only with blood vessel endothelial cells. The spindle cells, like lymphatic endothelial cells, were non‐reactive with PAL‐E but showed positive reaction with EN‐4 antibodies. The observed morphologic pattern of vasculogenesis and the demonstrated immune‐reactivity in KS support an origin from the venul‐lymphatic junction. This is an aberrant pattern but reminiscent of normal embryonal lymphatic channel development. The lymphatic capillaries and vascular slits were nonreactive with LN‐3 antibody, but it was positive on cell membranes in a number of spindle cells, suggesting the focal expression of la‐anitgens.

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mentioning

confidence: 99%

Expression of endothelial cell markers PAL‐E and EN‐4 and la‐antigens in Kaposi's sarcoma

Nadimi

Saatee

Armin

et al. 1988

J Oral Pathology Medicine

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“…Endothelial cells are the putative target cells for Kaposi sarcoma (10,11), a tumor commonly seen in the acquired immunodeficiency syndrome (AIDS) (12). We have been studying the pathogenesis of Kaposi sarcoma by evaluating in vitro susceptibility of endothelial cells to viruses implicated in the cause of AIDS.…”

mentioning

confidence: 99%

“…(26)(27)(28)(29). In particular, HTLV-I can induce some human neoplastic cells to form multinucleated cells by fusion (9,30 Endothelial cells are the putative target cells for Kaposi sarcoma (10,11), a neoplasm commonly seen in AIDS. HTLV-I was previously implicated in the, pathogenesis of AIDS (19,23,34), but recent studies suggest that a related human retrovirus, HTLV-III or LAV, is the probable etiologic agent (14)(15)(16)(17)(18).…”

mentioning

confidence: 99%

Infection of human endothelial cells by human T-lymphotropic virus type I.

Ho¹,

Rota²,

Hirsch³

1984

Proc. Natl. Acad. Sci. U.S.A.

119

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We studied the effects of human T-lymphotropic virus type I (HTLV-I) on human endothelial cells in vitro. During cocultivation with an HTLV-I producer cell line (C91/PL), endothelial cells formed characteristic multinucleated syncytial giant cells. Inoculation with concentrated cellfree supernatant fluid from C91/PL cultures produced similar cytopathic effects, which were neutralized by pretreatment with HTLV-I specific human serum. HTLV-I antigens were detected in the cytoplasm of the multinucleated cells by indirect immunofluorescence. When endothelial cells showed maximal cytopathic changes, reverse transcriptase activity was demonstrated in the supernatant fluid and HTLV-I was isolated by cocultivation with peripheral blood mononuclear cells. This study demonstrates that HTLV-I tropism is not limited to lymphoid cells but extends to human endothelial cells as well.

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“…However, Guarda ct al. [9], Nadji et al [16] and Flotte et al [8] have demonstrated beyond doubt the presence of factor-VIII-rclated antigen in endothelial cells o f Kaposi's sarcoma, and have thus proven the endothelial origin o f the tumor in both the classical as well as the AIDS-associ ated forms.…”

Section: Resultsmentioning

confidence: 99%

Erythrophagocytosis in Kaposi’s Sarcoma in Acquired Immune Deficiency Syndrome

Schenk¹

1986

ORL

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The ultrastructural morphology of Kaposi’s sarcoma of the oral mucosa in patients with acquired immune deficiency syndrome (AIDS) was examined electron-microscopically. Neoplastic spindle cells and vascular endothelial tumor cells are frequently involved in the phagocytosis of extra vasated erythrocytes. Pericytes, fibroblasts, macrophages and other phagocytic cells of the tumor stroma also participate in this process. Erythrocytes are also phagocytized by some of the keratinocytes belonging to the intact surface epithelium covering the Kaposi’s sarcoma lesion. Both the phenomenon of erythrophagocytosis and the presence of tubuloreticular structures in the cytoplasm of Kaposi’s sarcoma cells in patients with AIDS seem to be prominent ultrastructural markers and thus of diagnostic value.

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Factor VIII-Related Antigen in Kaposi's Sarcoma in Young Homosexual Men

Cited by 28 publications

References 16 publications

Expression of endothelial cell markers PAL‐E and EN‐4 and la‐antigens in Kaposi's sarcoma

Expression of endothelial cell markers PAL‐E and EN‐4 and la‐antigens in Kaposi's sarcoma

Infection of human endothelial cells by human T-lymphotropic virus type I.

Erythrophagocytosis in Kaposi’s Sarcoma in Acquired Immune Deficiency Syndrome

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