Factor VIII deficiency does not protect against atherosclerosis

Biere-Rafi, Sara; Tuinenburg, A.; Haak, Bastiaan W.; Peters, M.; Huijgen, Roeland; Groot, Eric de; Verhamme, Peter; Peerlinck, Kathelijne; Visseren, Frank L.J.; Kruip, Marieke J.H.A.; Gorkom, Britta A P Laros-van; Gerdes, V.E.A.; Büller, H. R.; Schutgens, Roger E. G.; Kamphuisen, Pieter Willem

doi:10.1111/j.1538-7836.2011.04499.x

Cited by 71 publications

(83 citation statements)

References 35 publications

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“…At least two directions for further investigation to define the role of MPs in hemophilia A may be drawn from the present work: (i) transient increases in circulating MP counts may be a safe possibility for the improvement of hemostatic status in hemophilia A and therefore there may be some therapeutic opportunities [24]; (ii) knowing the role of MPs in atherothrombosis and the facts that hemophilia is not considered protective against thrombosis [25,26] and that infusion of FVIII or by-pass agents may potentially precipitate a thrombotic event [27], it would be of particular importance to define the role of MPs in hemophilia A.…”

Section: Discussionmentioning

confidence: 98%

Is a decrease of microparticles related to improvement of hemostasis after FVIII injection in hemophilia A patients treated on demand?

Mobarrez

Miković²,

Antovič

et al. 2013

Journal of Thrombosis and Haemostasis

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Blood samples were taken before and 30 min after FVIII injection in 18 patients with severe hemophilia A treated on demand. Flow-cytometric determination of total MPs (TMPs) using lactadherin, platelet MPs (PMPs) (CD42a), endothelial MPs (EMPs) (CD144) and leukocyte MPs (LMPs) (CD45) was performed. The results were compared with data on endogenous thrombin potential (ETP), overall hemostatic potential (OHP), fibrin gel permeability and thrombin-activatable fibrinolysis inhibitor (TAFI). Results and Conclusions: TMPs and PMPs decreased after treatment (to 1015 AE 221 [SEM] and 602 AE 134 9 10 6 L À1 ) in comparison with values before treatment (2373 AE 618 and 1316 AE 331; P < 0.01). EMPs also decreased after treatment (78 AE 12 vs. 107 AE 13; P < 0.05) while LMPs were not influenced. Both TMP and PMP counts were inversely correlated, moderately but statistically significantly, with data on OHP, ETP, fibrin network permeability and TAFI/TAFIi (P < 0.05 for all). EMP counts were correlated only with ETP (P < 0.05), while LMP counts did not show any correlation. TMP and PMP counts were also inversely correlated with FVIII levels (P < 0.05).TMP, PMP and EMP counts decreased after on-demand treatment with FVIII concentrate in hemophilia A patients. The decrease in circulating MPs, which were inversely correlated with hemostatic activation, may imply that MPs are incorporated in the hemostatic plug formed after FVIII substitution at the site of injury.

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Section: Discussionmentioning

confidence: 98%

Is a decrease of microparticles related to improvement of hemostasis after FVIII injection in hemophilia A patients treated on demand?

Mobarrez

Miković²,

Antovič

et al. 2013

Journal of Thrombosis and Haemostasis

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“…8 Recently, 2 studies investigated whether hypocoagulability is associated with decreased atherogenesis by evaluating subclinical atherosclerosis and endothelial function in hemophilia patients and in matched unaffected controls. 6,7 The first study, a multicenter study from The Netherlands and Belgium compared 51 hemophilia A and B patients with obesity, as a proxy for increased cardiovascular risk, with 47 normal weight hemophiliacs and healthy age-matched controls with (42) and without (50) obesity. 6 The mean age of the subjects was 50 years and none had previous CVD.…”

Section: Atherosclerosis In Patients With Hemophiliamentioning

confidence: 99%

“…6,7 The first study, a multicenter study from The Netherlands and Belgium compared 51 hemophilia A and B patients with obesity, as a proxy for increased cardiovascular risk, with 47 normal weight hemophiliacs and healthy age-matched controls with (42) and without (50) obesity. 6 The mean age of the subjects was 50 years and none had previous CVD. Carotid IMT was increased in obese (0.77 6 0.22 mm) compared with nonobese subjects (0.69 6 0.16 mm).…”

Section: Atherosclerosis In Patients With Hemophiliamentioning

confidence: 99%

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Cardiovascular risk in patients with hemophilia

Kamphuisen

Cate

2014

Blood

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Patients with hemophilia, who have a lifelong hypocoagulability, seem to have a lower cardiovascular mortality than the general population. Nevertheless, the prevalence of cardiovascular risk factors in patients with hemophilia is as prevalent as in the general population, and hypertension is even more common. Furthermore, hemophiliacs have the same degree of atherosclerosis as the general population. The reduced cardiovascular mortality may be explained by reduced thrombus formation resulting from hypocoagulability. On the other hand, hemophilia, which is associated with reduced thrombin generation, may also increase atherosclerotic plaque stability, as has been shown in mice. Because treatment of these events is extremely challenging in patients with increased bleeding tendency, detection and aggressive treatment of risk factors is mandatory.

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“…The second was a study measuring IMT and flow-mediated dilatation (FMD) in 51 obese and 47 nonobese patients and 42 obese and 50 nonobese controls [29].There were no differences between the groups.…”

Section: Cholesterolmentioning

confidence: 99%