Factor VIII coagulant antigen in factor IX complex concentrates

Onder, Oguz; Hoyer, Leon W.

doi:10.1016/0049-3848(79)90164-6

Cited by 26 publications

(6 citation statements)

References 8 publications

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“…Disappointingly, anamnestic response of the factor VIII antibody is sometimes observed (Lechner et al, 1978;Kasper, 1979). This, presumably, is because the concentrates contain appreciable quantities of factor VIII coagulant antigen (Onder & Hoyer, 1979). This appears to be ofa lower molecular weight type dissociated from factor VIII related antigen which is present only in minute amounts (Parry & Bloom, 1978).…”

Section: Prothrombin Complex Concentrates (Pcc)mentioning

confidence: 99%

Factor Viii Inhibitors Revisited

Bloom¹

1981

Br J Haematol

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Section: Prothrombin Complex Concentrates (Pcc)mentioning

confidence: 99%

Factor Viii Inhibitors Revisited

Bloom¹

1981

Br J Haematol

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“…PCC, whether activated or not, when being used for hemophilia A patients with inhibitor, it would naturally be preferable that these preparations do not contain this antigen. Its presence has nevertheless been reported by several authors [26,27],…”

Section: Resultsmentioning

confidence: 87%

Appraisal of the Protein Composition of Prothrombin Complex Concentrates of Different Origins

Pejaudier¹,

Kichenin-Martin²,

Boffa³

et al. 1987

Vox Sanguinis

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The protein composition of 12 different prothrombin complex concentrates, including 2 purified factor IX concentrates and 2 activated fractions, was evaluated. There is a clear difference between ion exchanger-prepared fractions and those obtained by adsorption onto calcium phosphate. The former contain high molecular weight kininogen and complement components, the latter only trace amounts of these proteins but relatively high quantities of the pro- and even partially activated enzymes of the contact phase. Calcium phosphate adsorbed preparations contain less VIII : CAg than the DEAE-Sephadex-prepared fractions. The inorganic adsorbent showed higher affinity for IgG than the ion exchangers.

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“…It was later confirmed by an immunoradiometric assay with the use of rabbit antihuman factor Vili R: Ag anti body by Parry and Bloom [117]. Onder and Hoyer [115], who employed highly specific human anti-factor VIII to identify antigenic determinants closely associated with factor VIII coagulant activity and the immunora diometric assay, demonstrated its presence in a substantial amount.…”

Section: Tests For the Detection Of Potential Thrombogenicitymentioning

confidence: 92%

Prothrombin Complex Concentrates for Clinical Use

Chandra¹,

Brummelhuis²

1981

Vox Sanguinis

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Prothrombin complex concentrates prepared for clinical use are reviewed with emphasis on frequently observed adverse reactions such as viral hepatitis and thromboembolic complications. Preparation procedures and quality control are described briefly, and the use of these concentrates in the treatment of hemophilia A patients who develop factor VIII inhibitors is also described. The causes of and methods for the detection of potential thrombogenicity are discussed and suggestions which may result in a safer product are made.

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Factor VIII coagulant antigen in factor IX complex concentrates

Cited by 26 publications

References 8 publications

Factor Viii Inhibitors Revisited

Factor Viii Inhibitors Revisited

Appraisal of the Protein Composition of Prothrombin Complex Concentrates of Different Origins

Prothrombin Complex Concentrates for Clinical Use

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