Factor V gene G1691A mutation, prothrombin gene G20210A mutation, and MTHFR gene C677T mutation are not risk factors for pulmonary thromboembolism in Chinese population

Lu, Yanhui; Zhao, Yang; Liu, Guozhang; Wang, Xiaoling; Liu, Zhihong; Chen, Baiping; Hui, Rutai

doi:10.1016/s0049-3848(02)00064-6

Cited by 56 publications

(45 citation statements)

References 22 publications

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“…This situation necessitates the generation of several appropriate age-dependent reference ranges to interpret laboratory data in pediatric patients and prevent misclassification of children having defects of factors and inhibitors of the coagulation system (7). Since there are differences in the hemostatic system among different racial/ethnic groups (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27), and also between different analyzer and reagent systems (4), coagulation laboratories should develop age-related reference ranges specific to their own testing systems for the local population (4,7,32). In this study, we analyzed retrospectively the results of preoperative APTT testing in childhood and adult controls undergoing minor elective surgery.…”

Section: Discussionmentioning

confidence: 99%

“…VTE is not as common in Chinese as in Caucasians (15). Genetic risk factors related to VTE in Caucasians such as factor V Leiden and prothrombin G20210A mutations are rare in Asian, especially in Chinese and Japanese (16)(17)(18)(19)(20)(21)(22). The mean plasma concentrations of factors VII, VIII and fibrinogen were lower in Japanese than in Caucasians (23).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children

Lai

Yan

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children

Lai

Yan

et al. 2009

Clinical Chemistry and Laboratory Medicine

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“…The pattern of congenital thrombophilia between Chinese and Caucasians was very different. Factor V Leiden (FVL) (G1691→A) and prothrombin gene (G20210→A) mutations are common thrombophilia for VTE in Caucasians, whereas they are extremely rare among Chinese [11,16,17,18,19,20,21,22,23,24,25,26,27]. Recently, hyperhomocysteinemia was also thought to be another risk factor for VTE [28,29] but its role in VTE during pregnancy was not known in the Chinese context.…”

Section: Introductionmentioning

confidence: 99%

Thrombophilia among Chinese Women with Venous Thromboembolism during Pregnancy

Tam

Ng²,

Yiu

et al. 2012

Gynecol Obstet Invest

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Aims: To assess the prevalence of thrombophilia among Chinese women with venous thromboembolism (VTE) developed during pregnancy. Methods: Based on information from a tertiary teaching unit, all recorded cases of deep vein thrombosis (DVT) and pulmonary embolism (PE) during pregnancy diagnosed between 1997 and 2005, were assessed for prevalence of thrombophilia. Fifty-five healthy women, who had at least one normal pregnancy but without any previous history of VTE, were recruited as controls. Results: A total of 44 subjects completed thrombophilia screening, of whom 5 (11%) were confirmed to have thrombophilia [protein C (PC) deficiency (2), protein S (PS) deficiency (1), combined PC & PS deficiency (1) and antithrombin III deficiency (1)]. Homozygous 5,10-methylenetetrahydrofolate reductase (C677T) gene mutation was found in 6 (14%) subjects but not in the controls. There was no antiphospholipid syndrome, activated PC resistance, factor V Leiden or prothrombin gene mutations. Conclusion: In the Chinese population, PS and PC deficiencies are common thrombophilia for VTE during pregnancy and thrombophilia screening should be recommended in all pregnant women who suffer from VTE.

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“…The presence of these genetic variations is associated with a hypercoagulable state, and increases the risk of thromboembolic events. Such phenomena, however, have been observed mainly in Caucasians, and an association between genetic predisposition and thrombotic tendency may differ between ethnic groups [1,13,14,16,20]. Recent studies suggest these genetic predispositions play a role in the risk of ONFH [26,27], but it is unclear whether they apply to non-Caucasian populations.…”

Section: Introductionmentioning

confidence: 99%

Genetic Background of Nontraumatic Osteonecrosis of the Femoral Head in the Korean Population

Chang

Hur

Lee

et al. 2008

Clinical Orthopaedics &Amp; Related Research

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Major thrombophilic mutations have been identified as risk factors for nontraumatic osteonecrosis of the femoral head (ONFH) in Caucasians. We asked whether the genetic background of patients with ONFH in the Korean population was similar. We analyzed factor V G1691A mutation (factor V Leiden), prothrombin G20210A mutation, and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in 71 patients (53 men, 18 women) with ONFH. We classified these patients as 51 alcohol-induced, 18 idiopathic, one steroid-induced, and one dysbaric. We recruited 200 normal control subjects (128 men, 72 women). We used multiplex PCR/restriction fragment length polymorphism for each genotyping. We observed neither factor V Leiden nor prothrombin G20210A mutation. Although methylenetetrahydrofolate reductase A1298C genotypes were not associated with osteonecrosis, methylenetetrahydrofolate reductase C677T variant genotypes increased the risk of ONFH compared with 677CC. Odds ratios of 677CT and 677CT+TT were 2.00 (95% confidence interval, 1.05-3.81) and 1.96 (95% confidence interval, 1.07-3.59), respectively, compared with 677CC. Our data suggest methylenetetrahydrofolate reductase C677T polymorphism plays a role in the pathogenesis of osteonecrosis in the Korean population. It also implies the genetic risk profile of ONFH may differ among ethnic populations.

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Factor V gene G1691A mutation, prothrombin gene G20210A mutation, and MTHFR gene C677T mutation are not risk factors for pulmonary thromboembolism in Chinese population

Cited by 56 publications

References 22 publications

Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children

Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children

Thrombophilia among Chinese Women with Venous Thromboembolism during Pregnancy

Genetic Background of Nontraumatic Osteonecrosis of the Femoral Head in the Korean Population

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