Factor Structure of the Geriatric Depression Scale and Relationships with Cognition and Function in Alzheimer’s Disease

Havins, Whitney; Massman, Paul J.; Doody, Rachelle S.

doi:10.1159/000345787

Cited by 17 publications

(9 citation statements)

References 62 publications

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“…Robot-assisted cognitive training showed increased cognitive capabilities for people with limited social capabilities, such as children with ASD (Huijnen et al, 2016 ; Esteban et al, 2017 ; Marino et al, 2019 ) and people with dementia (Sung et al, 2015 ; Yu et al, 2015 ; Otaki and Otake, 2017 ). Due to cognitive impairment, individuals with dementia may also show deficits in social functioning, such as social withdrawal (Havins et al, 2012 ; Dickerson, 2015 ). In the pilot study by Sung et al ( 2015 ) about robot-assisted therapy using socially assistive pet robot (PARO), institutionalized older adults showed significantly increased communication and interaction skills and activity participation after receiving 4-week robot-assisted therapy.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Robotic Rehabilitation for Cognitive Training

et al. 2021

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A large and increasing number of people around the world experience cognitive disability. Rehabilitation robotics has provided promising training and assistance approaches to mitigate cognitive deficits. In this article, we carried out a systematic review on recent developments in robot-assisted cognitive training. We included 99 articles in this work and described their applications, enabling technologies, experiments, and products. We also conducted a meta analysis on the articles that evaluated robot-assisted cognitive training protocol with primary end users (i.e., people with cognitive disability). We identified major limitations in current robotics rehabilitation for cognitive training, including the small sample size, non-standard measurement of training and uncontrollable factors. There are still multifaceted challenges in this field, including ethical issues, user-centered (or stakeholder-centered) design, the reliability, trust, and cost-effectiveness, personalization of the robot-assisted cognitive training system. Future research shall also take into consideration human-robot collaboration and social cognition to facilitate a natural human-robot interaction.

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Section: Resultsmentioning

confidence: 99%

A Systematic Review of Robotic Rehabilitation for Cognitive Training

et al. 2021

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“…Apart from memory deficits, the severity of AD is also associated with impairment of exploratory behaviors, especially showing a loss of curiosity into novel surroundings or environment ( Havins et al, 2012 ). In agreement with this view, isolated aged APP/PS1 mice showed low exploratory activity in the open field test compared with their group controls.…”

Section: Discussionmentioning

confidence: 99%

Isolation Housing Exacerbates Alzheimer's Disease-Like Pathophysiology in Aged APP/PS1 Mice

Huang

Wang

Cao

et al. 2015

International Journal of Neuropsychopharmacology

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Background:Alzheimer’s disease is a neurodegenerative disease characterized by gradual declines in social, cognitive, and emotional functions, leading to a loss of expected social behavior. Social isolation has been shown to have adverse effects on individual development and growth as well as health and aging. Previous experiments have shown that social isolation causes an early onset of Alzheimer’s disease-like phenotypes in young APP695/PS1-dE9 transgenic mice. However, the interactions between social isolation and Alzheimer’s disease still remain unknown.Methods:Seventeen-month-old male APP695/PS1-dE9 transgenic mice were either singly housed or continued group housing for 3 months. Then, Alzheimer’s disease-like pathophysiological changes were evaluated by using behavioral, biochemical, and pathological analyses.Results:Isolation housing further promoted cognitive dysfunction and Aβ plaque accumulation in the hippocampus of aged APP695/PS1-dE9 transgenic mice, associated with increased γ-secretase and decreased neprilysin expression. Furthermore, exacerbated hippocampal atrophy, synapse and myelin associated protein loss, and glial neuroinflammatory reactions were observed in the hippocampus of isolated aged APP695/PS1-dE9 transgenic mice.Conclusions:The results demonstrate that social isolation exacerbates Alzheimer’s disease-like pathophysiology in aged APP695/PS1-dE9 transgenic mice, highlighting the potential role of group life for delaying or counteracting the Alzheimer’s disease process.

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“…Apathy is commonly rated as a severe and frequent behavior on the NPI for individuals with AD [31] and strongly correlated to cognitive ability [32]. Elevated apathy at baseline has also been associated with decreasing functional status across the AD spectrum from normal controls to mild AD [33].…”

Section: Discussionmentioning

confidence: 99%

Neuropsychiatric Symptoms Predict Functional Status in Alzheimer’s Disease

You

Walsh

Chiodo

et al. 2015

JAD

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Background Cognitive deficits are presumed to be the primary driver of functional impairment in Alzheimer’s disease (AD); however, functional impairment is likely multifactorially determined. Objective Our objective was to determine the relative contribution of neuropsychiatric symptoms in predicting ratings of functional status. Methods A total of 223 patients received routine neurological and neuropsychological evaluations and met criteria of probable AD dementia based on the McKhann criteria. Demographic, cognitive, and neuropsychiatric variables were entered in a hierarchical linear regression analysis to predict functional status as measured by the Functional Activities Questionnaire (FAQ). Results The total model explained 29.7% of the variance (p < 0.001) in FAQ. Importantly, neuropsychiatric variables explained 12.7% of the unique variance, with apathy and sleep as significant contributors. Conclusion Two neuropsychiatric variables, apathy and changes in sleep/nighttime behaviors, predicted ratings of functional status in AD patients independent of age, global cognition, memory and executive function measures, and depressive symptoms. These results highlight the importance of neuropsychiatric symptoms in understanding and potentially treating the functional limitations so prevalent in AD.

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Factor Structure of the Geriatric Depression Scale and Relationships with Cognition and Function in Alzheimer’s Disease

Cited by 17 publications

References 62 publications

A Systematic Review of Robotic Rehabilitation for Cognitive Training

A Systematic Review of Robotic Rehabilitation for Cognitive Training

Isolation Housing Exacerbates Alzheimer's Disease-Like Pathophysiology in Aged APP/PS1 Mice

Neuropsychiatric Symptoms Predict Functional Status in Alzheimer’s Disease

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