“…Then, the anaphylatoxins bind to secretory cells (mast cells, basophils, macrophages, other phagocytic cells, and leukocytes) leading to the release/production of a multitude of secondary mediators (including histamine, tryptase, platelet-activating factor, thromboxane A 2 , leukotrienes (LTs), cytokines, proteases, and prostaglandins) [14,15]. The complement cascade can be triggered by the classical pathway (CP), lectin pathway (LP) or alternative pathway (AP) [16] in which complement component 3 (C3) plays an important role (Fig. 1).…”