Facing adenocarcinoma of distal esophagus and esophagogastric junction: a CROSS versus FLOT propensity score-matched analysis of oncological outcomes in a high-volume institution

Lombardi, Pietro; Pansa, Andrea; Basato, Silvia; Giorgi, Lorenzo; Perano, Vittoria; Marano, Salvatore; Castoro, Carlo

doi:10.1007/s13304-023-01497-5

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Current Standard Of Care and Its Challenges1

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2023

2024

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Cited by 4 publications

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“…A recent retrospective study directly comparing FLOT vs CROSS shows similar 5-year overall survival in patients receiving FLOT and CROSS despite a higher pCR with CROSS [ 77 ]. Other recent smaller studies demonstrate similar survival patterns between CROSS and FLOT but show higher distant recurrence and postoperative respiratory failure with CROSS [ 78 , 79 ]. Results from the ESOPEC Phase III trial are eagerly awaited [ 44 ].…”

Section: Current Standard Of Care and Its Challengesmentioning

confidence: 79%

Total neoadjuvant therapy in oesophageal and gastro-oesophageal junctional adenocarcinoma

Clements,

Underwood,

Petty

2023

Br J Cancer

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Adenocarcinoma of the oesophagus and gastro-oesophageal junction represent a large burden of cancer death in the Western World with an increasing incidence. In the past two decades, the overall survival of patients on a potentially curative treatment pathway has more than doubled due to the addition of perioperative oncological therapies to surgery. However, patients often fail to respond to oncological treatment or struggle to complete their treatment after surgery. In this review, we discuss the current evidence for total neoadjuvant therapy and options for assessment of treatment response.

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Section: Current Standard Of Care and Its Challengesmentioning

confidence: 79%