Facilitation of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate receptor transmission in the suprachiasmatic nucleus by aniracetam enhances photic responses of the biological clock in rodents

Moriya, Takuya; Ikeda, Masayuki; Teshima, Koji; Hara, Reiko; Kuriyama, Koji; Yoshioka, Tohru; Allen, Charles N.; Shibata, Shigenobu

doi:10.1046/j.1471-4159.2003.01758.x

Cited by 13 publications

(6 citation statements)

References 48 publications

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“…Actually, Mintz and coworkers reported that the degree of NMDA-induced phase-advances during the late subjective night was lower than that of light pulse-induced, although the phase-delays during the early subjective night obtained by both methods were quite similar [11]. Interestingly, Moriya and coworkers reported that aniracetam, an enhancer of AMPAR activity, augmented light-induced phase-shifts at CT14, but not at CT20 [21]. These findings strongly suggest that light-induced phase-advances during the late subjective night need not only glutamatergic stimuli, but also additional factor(s).…”

Section: Discussionmentioning

confidence: 99%

“…In the SCN slices in vitro , Shibata and coworkers demonstrated that AMPA application induced phase-shifts of neuronal firing rhythms similar to NMDA [13]. Moreover, it was recently shown that AMPA application increased the calcium concentration in the SCN slices [21]. These studies prompted us to re-evaluate the effects of AMPA both on the regulation of phase-shifts of behavioral rhythms and on clock gene expression.…”

Section: Introductionmentioning

confidence: 99%

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Activation of AMPA Receptors in the Suprachiasmatic Nucleus Phase-Shifts the Mouse Circadian Clock In Vivo and In Vitro

et al. 2010

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The glutamatergic neurotransmission in the suprachiasmatic nucleus (SCN) plays a central role in the entrainment of the circadian rhythms to environmental light-dark cycles. Although the glutamatergic effect operating via NMDAR (N-methyl D-aspartate receptor) is well elucidated, much less is known about a role of AMPAR (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor) in circadian entrainment. Here we show that, in the mouse SCN, GluR2 and GluR4 AMPAR subtypes are abundantly expressed in the retinorecipient area. In vivo microinjection of AMPA in the SCN during the early subjective night phase-delays the behavioral rhythm. In the organotypic SCN slice culture, AMPA application induces phase-dependent phase-shifts of core-clock gene transcription rhythms. These data demonstrate that activation of AMPAR is capable of phase-shifting the circadian clock both in vivo and in vitro, and are consistent with the hypothesis that activation of AMPA receptors is a critical step in the transmission of photic information to the SCN.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Activation of AMPA Receptors in the Suprachiasmatic Nucleus Phase-Shifts the Mouse Circadian Clock In Vivo and In Vitro

et al. 2010

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“…Our evidence suggests that PACAP regulation of the magnitude of AMPA currents is dependent upon PAC1 receptors and the adenylyl cyclase-signalling cascade. Interestingly, a recent study found evidence suggesting that the enhancement of AMPA mediated synaptic transmission in the SCN is sufficient to increase the magnitude of light-induced phase delays [ 52 ]. Finally, PACAP can increase Ca 2+ by itself as well as enhance AMPA- and glutamate -evoked increases in Ca 2+ [ 16 , 17 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus

et al. 2006

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Background: Previous studies indicate that light information reaches the suprachiasmatic nucleus (SCN) through a subpopulation of retinal ganglion cells that contain both glutamate and pituitary adenylyl cyclase activating peptide (PACAP). While the role of glutamate in this pathway has been well studied, the involvement of PACAP and its receptors are only beginning to be understood. Speculating that PACAP may function to modulate how neurons in the suprachiasmatic nucleus respond to glutamate, we used electrophysiological and calcium imaging tools to examine possible cellular interactions between these co-transmitters.

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“…1 in (Brown, 2016)]. Application of pharmacological mimics of the light-input pathways to living SCN slices, such as glutamate or the glutamate receptor agonists AMPA and NMDA, also causes phase shifts in the electrical rhythms that imitate the lightinduced shifts in locomotor activity (Colwell & Menaker, 1992;Shibata et al, 1994;Biello et al, 1997;Ding et al, 1998;Moriya et al, 2000Moriya et al, , 2003. Similarly, optogenetic manipulation of SCN activity causes phase shifts in electrical and gene expression rhythms both in vivo and in vitro (Jones et al, 2015).…”

Section: Function Of Neuronal Oscillations In the Scnmentioning

confidence: 99%

Neuronal oscillations on an ultra‐slow timescale: daily rhythms in electrical activity and gene expression in the mammalian master circadian clockwork

Belle

Diekman

2018

Eur J of Neuroscience

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Neuronal oscillations of the brain, such as those observed in the cortices and hippocampi of behaving animals and humans, span across wide frequency bands, from slow delta waves (0.1 Hz) to ultra-fast ripples (600 Hz). Here, we focus on ultra-slow neuronal oscillators in the hypothalamic suprachiasmatic nuclei (SCN), the master daily clock that operates on interlocking transcription-translation feedback loops to produce circadian rhythms in clock gene expression with a period of near 24 h (< 0.001 Hz). This intracellular molecular clock interacts with the cell's membrane through poorly understood mechanisms to drive the daily pattern in the electrical excitability of SCN neurons, exhibiting an up-state during the day and a down-state at night. In turn, the membrane activity feeds back to regulate the oscillatory activity of clock gene programs. In this review, we emphasise the circadian processes that drive daily electrical oscillations in SCN neurons, and highlight how mathematical modelling contributes to our increasing understanding of circadian rhythm generation, synchronisation and communication within this hypothalamic region and across other brain circuits.

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Facilitation of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate receptor transmission in the suprachiasmatic nucleus by aniracetam enhances photic responses of the biological clock in rodents

Cited by 13 publications

References 48 publications

Activation of AMPA Receptors in the Suprachiasmatic Nucleus Phase-Shifts the Mouse Circadian Clock In Vivo and In Vitro

Activation of AMPA Receptors in the Suprachiasmatic Nucleus Phase-Shifts the Mouse Circadian Clock In Vivo and In Vitro

Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus

Neuronal oscillations on an ultra‐slow timescale: daily rhythms in electrical activity and gene expression in the mammalian master circadian clockwork

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