Facilitation of sexual receptivity in hamsters by simultaneous progesterone implants into the VMH and ventral mesencephalon

Pleim, Eric T.; Lisciotto, Christine A.; DeBold, Joseph F.

doi:10.1016/0018-506x(90)90001-e

Cited by 50 publications

(20 citation statements)

References 25 publications

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“…Ovulation and receptivity occur about 24 hours after this peak has been reached [162]. This time frame is in agreement with the activation by estrogen of the transcription of hypothalamic progesterone receptors that appear to be required for the activation of female sexual receptivity [158,162,196]. The pre-ovulation secretion of estrogen appears even slower in primates including humans [117,280].…”

Section: Gonadal Production Of Steroidsmentioning

confidence: 74%

Functional significance of the rapid regulation of brain estrogen action: Where do the estrogens come from?

2006

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Estrogens exert a wide variety of actions on reproductive and non-reproductive functions. These effects are mediated by slow and long lasting genomic as well as rapid and transient non-genomic mechanisms. Besides the host of studies demonstrating the role of genomic actions at the physiological and behavioral level, mounting evidence highlights the functional significance of non-genomic effects. However, the source of the rapid changes in estrogen availability that are necessary to sustain their fast actions is rarely questioned. For example, the rise of plasma estrogens at pro-estrus that represents one of the fastest documented changes in plasma estrogen concentration appears too slow to explain these actions. Alternatively, estrogen can be synthesized in the brain by the enzyme aromatase providing a source of locally high concentrations of the steroid. Furthermore, recent studies demonstrate that brain aromatase can be rapidly modulated by afferent inputs, including glutamatergic afferents. A role for rapid changes in estrogen production in the central nervous system is supported by experiments showing that acute aromatase inhibition affects nociception as well as male sexual behavior and that preoptic aromatase activity is rapidly (within min) modulated following mating. Such mechanisms thus fulfill the gap existing between the fast actions of estrogen and their mode of production and open new avenues for the understanding of estrogenic effects on the brain.

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Section: Gonadal Production Of Steroidsmentioning

confidence: 74%

Functional significance of the rapid regulation of brain estrogen action: Where do the estrogens come from?

2006

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“…For sexual receptivity, hamsters require central actions of P in both the VTA and VMH [27, 28]. As in previous experiments [17], a standard subthreshold hormone-priming regimen, which consisted of systemic administration of E 2 (10 µg, h 0) and P (100 µg, h 45), was utilized to ascertain whether co-administration of receptor agonists could enhance P’s efficacy in the VTA to facilitate sexual behavior.…”

Section: Methodsmentioning

confidence: 99%

In the Ventral Tegmental Area, Progestins’ Membrane-Mediated Actions for Lordosis of Hamsters and Rats Involve Protein Kinase A

Petralia

Walf²,

Frye³

2006

Neuroendocrinology

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Progestin-facilitated lordosis of hamsters and rats is enhanced by activation of dopamine type 1 (D₁) or GABA_A/benzodiazepine receptor complexes (GBRs) in the ventral tegmental area (VTA) and these effects involve G-proteins and second messengers, such as adenosine 3′,5′-monophosphate (cAMP). We examined whether D₁- and/or GBR-mediated increases in progestin-facilitated lordosis of female hamsters and rats involve the cAMP-dependent protein kinase, protein kinase A (PKA), in the VTA. In experiment 1, ovariectomized hamsters, primed with estradiol (E₂; 10 µg at h 0) + progesterone (P; 100 µg at h 45), were first pre-tested for lordosis and motor behavior (h 48) and then infused with the PKA inhibitor, Rp-cAMP (100 ng/side), or vehicle. Thirty minutes later, hamsters were retested and then received infusions of the D₁ agonist, SKF38393 (100 ng/side), the GBR agonist, muscimol (100 ng/side), or vehicle to the VTA. Hamsters were post-tested for lordosis and motor behavior 30 min later. In Experiment 2, ovariectomized rats, primed with E₂ (10 µg at h 0), were first pre-tested for lordosis and then infused with Rp-cAMP (100 ng/side) or vehicle to the VTA at h 44. Immediately after testing, rats received infusions of SKF38393 (100 ng/side), muscimol (100 ng/side), or vehicle and were retested for lordosis. Rats were then infused with the neurosteroid, 5α-pregnan-3α-ol-20-one (3α,5α-THP; 100 or 200 ng/side), or β-cyclodextrin vehicle and were post-tested for lordosis and motor behavior 10 and 60 min later. The enhancing effects of progestins or progestins plus D₁ or GBR activation on lordosis of E₂-primed hamsters and rats were blocked by the PKA inhibitor, Rp-cAMP. Thus, in the VTA, progestins’ membrane actions involving D₁ or GBRs are mediated, in part, by PKA.

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“…Among E 2 -primed hamsters, P's actions are required in both the VMH and the VTA for lordosis to occur (DeBold and Malsbury 1989;Pleim et al 1990). In the VTA, P's actions for lordosis occur at cellular membranes, rather than at E 2 -induced intracellular progestin receptors, as is the case in the VMH.…”

mentioning

confidence: 97%

“…The following experiments test the hypothesis that, in the VTA, P has actions at D 1 for lordosis that are mediated, in part, by G-proteins. As well, this hypothesis is tested in rats, which are less reliant, and hamsters, which are highly dependent upon P's central actions in the VTA for lordosis (DeBold and Malsbury 1989;Pleim et al 1990Pleim et al , 1991Frye and Gardiner 1996).…”

mentioning

confidence: 97%

In the ventral tegmental area, G-proteins mediate progesterone’s actions at dopamine type 1 receptors for lordosis of rats and hamsters

Petralia

Frye

2006

Psychopharmacology

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Facilitation of sexual receptivity in hamsters by simultaneous progesterone implants into the VMH and ventral mesencephalon

Cited by 50 publications

References 25 publications

Functional significance of the rapid regulation of brain estrogen action: Where do the estrogens come from?

Functional significance of the rapid regulation of brain estrogen action: Where do the estrogens come from?

In the Ventral Tegmental Area, Progestins’ Membrane-Mediated Actions for Lordosis of Hamsters and Rats Involve Protein Kinase A

In the ventral tegmental area, G-proteins mediate progesterone’s actions at dopamine type 1 receptors for lordosis of rats and hamsters

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