Facilitation of Sexual Behavior and Enhanced Dopamine Efflux in the Nucleus Accumbens of Male Rats afterd-Amphetamine-Induced Behavioral Sensitization

Fiorino, Dennis F.; Phillips, Anthony G.

doi:10.1523/jneurosci.19-01-00456.1999

Cited by 150 publications

(77 citation statements)

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“…An environment paired with repeated morphine injections can facilitate sexual behavior in male rats (Mitchell and Stewart, 1990a,b). Amphetamine pretreatment also facilitates sexual behavior in sexually naive male rats and is correlated with augmented dopamine release in the nucleus accumbens (Fiorino and Phillips, 1999). c-Fos expression was analyzed in the nucleus accumbens after amphetamine treatment.…”

Section: Sexual Experience Effects On Amphetamine-induced Locomotor Amentioning

confidence: 99%

“…In other words, the dopamine neurons previously sensitized to one drug will exhibit sensitized responses to another drug given for the first time (Cunningham and Kelley, 1992;Pierce and Kalivas, 1997a;Birrell and Balfour, 1998;Taylor and Horger, 1999). In addition to cross-sensitization among drugs, several studies have reported cross-sensitization between repeated exposures to pharmacological agents and natural motivated behaviors (Mitchell and Stewart, 1990a,b;Tidey and Miczek, 1997;Fiorino and Phillips, 1999). Therefore, we examined whether sexually experienced and sexually naive animals would respond differently to a novel stimulus known to activate dopamine pathways (i.e., cross-sensitization), such as amphetamine.…”

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confidence: 99%

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Sexual Behavior Induction of c-Fos in the Nucleus Accumbens and Amphetamine-Stimulated Locomotor Activity Are Sensitized by Previous Sexual Experience in Female Syrian Hamsters

Bradley¹,

Meisel

2001

J. Neurosci.

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Dopamine transmission in the nucleus accumbens can be activated by drugs, stress, or motivated behaviors, and repeated exposure to these stimuli can sensitize this dopamine response. The objectives of this study were to determine whether female sexual behavior activates nucleus accumbens neurons and whether past sexual experience cross-sensitizes neuronal responses in the nucleus accumbens to amphetamine. Using immunocytochemical labeling, c-Fos expression in different subregions (shell vs core at the rostral, middle, and caudal levels) of the nucleus accumbens was examined in female hamsters that had varying amounts of sexual experience. Female hamsters, given either 6 weeks of sexual experience or remaining sexually naive, were tested for sexual behavior by exposure to adult male hamsters. Previous sexual experience increased c-Fos labeling in the rostral and caudal levels but not in the middle levels of the nucleus accumbens. Testing for sexual behavior increased labeling in the core, but not the shell, of the nucleus accumbens. To validate that female sexual behavior can sensitize neurons in the mesolimbic dopamine pathway, the locomotor responses of sexually experienced and sexually naive females to an amphetamine injection were then compared. Amphetamine increased general locomotor activity in all females. However, sexually experienced animals responded sooner to amphetamine than did sexually naive animals. These data indicate that female sexual behavior can activate neurons in the nucleus accumbens and that sexual experience can cross-sensitize neuronal responses to amphetamine. In addition, these results provide additional evidence for functional differences between the shell and core of the nucleus accumbens and across its anteroposterior axis.Key words: female sexual behavior; nucleus accumbens; shell; core; c-Fos; sensitization; cross-sensitization; amphetamine Dopamine neurons originating in the midbrain ventral tegmental area and projecting to various forebrain nuclei, including the nucleus accumbens, are part of the mesolimbic dopamine system. It has been suggested that this dopamine system is important for the regulation of appetitive behaviors (Mitchell and Gratton, 1994;Salamone, 1994Salamone, , 1996Ikemoto and Panksepp, 1999), as well as self-administration of drugs of abuse (Pierre and Vezina, 1998;Koob, 1999;Lorrain et al., 1999;McKinzie et al., 1999;Peoples et al., 1999;Bradberry et al., 2000). Systemic administration of a variety of drugs of abuse (e.g., cocaine, amphetamine, and heroin) activates dopamine pathways (Pontieri et al., 1995;Nisell et al., 1997;Pierce and Kalivas, 1997a;Tanda et al., 1997;Tanda and Di Chiara, 1998;Barrot et al., 1999;Cadoni and Di Chiara, 1999), and repeated exposure to these pharmacological agents can sensitize these dopamine-responsive neurons (Robinson et al., 1988;Kalivas et al., 1992;Kalivas and Duffy, 1993;Pierce and Kalivas, 1995;Kuczenski et al., 1997;Nisell et al., 1997;Birrell and Balfour, 1998;Heidbreder and Feldon, 1998;Cadoni and Di Chiara, 1999;Ca...

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Section: Sexual Experience Effects On Amphetamine-induced Locomotor Amentioning

confidence: 99%

mentioning

confidence: 99%

Sexual Behavior Induction of c-Fos in the Nucleus Accumbens and Amphetamine-Stimulated Locomotor Activity Are Sensitized by Previous Sexual Experience in Female Syrian Hamsters

Bradley¹,

Meisel

2001

J. Neurosci.

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“…[1][2][3][4] Once established, behavioural sensitization is often accompanied by enhanced dopamine (DA) release in the nucleus accumbens (NAcc). [5][6][7] Whereas terminal regions of the mesocorticolimbic DA system are clearly implicated in the long term expression of druginduced sensitization, 8 its induction and initial maintenance depends on modulation of synaptic events in close proximity to DA-containing neurons in the ventral tegmental area (VTA). [8][9][10] The enduring neural adaptations that accompany repeated exposure to drugs of abuse have been linked to specific forms of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD).…”

Section: Introductionmentioning

confidence: 99%

Interference with AMPA receptor endocytosis: effects on behavioural and neurochemical correlates of amphetamine sensitization in male rats

Choi

Ahn

Wang

et al. 2014

J Psychiatry Neurosci

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“…The neural circuits implicated in the processing of these vital components of decision making, including dopamine and cortical systems, continue to develop throughout the adolescent period (3,20). Previous work assessing the consequences of drug use on future reward processing has shown that a history of drug exposure may alter neural and behavioral responses to natural rewards, effects thought to be mediated by dopamine systems (21). A corruption of reward valuation could promote maladaptive and suboptimal behavior by placing excessive priority on seeking rewards such as food, drugs, or sex.…”

mentioning

confidence: 99%

Risk preference following adolescent alcohol use is associated with corrupted encoding of costs but not rewards by mesolimbic dopamine

Nasrallah¹,

Clark

Collins³

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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Several emerging theories of addiction have described how abused substances exploit vulnerabilities in decision-making processes. These vulnerabilities have been proposed to result from pharmacologically corrupted neural mechanisms of normal brain valuation systems. High alcohol intake in rats during adolescence has been shown to increase risk preference, leading to suboptimal performance on a decision-making task when tested in adulthood. Understanding how alcohol use corrupts decision making in this way has significant clinical implications. However, the underlying mechanism by which alcohol use increases risk preference remains unclear. To address this central issue, we assessed dopamine neurotransmission with fast-scan cyclic voltammetry during reward valuation and risk-based decision making in rats with and without a history of adolescent alcohol intake. We specifically targeted the mesolimbic dopamine system, the site of action for virtually all abused substances. This system, which continuously develops during the adolescent period, is central to both reward processing and risk-based decision making. We report that a history of adolescent alcohol use alters dopamine signaling to risk but not to reward. Thus, a corruption of cost encoding suggests that adolescent alcohol use leads to long-term changes in decision making by altering the valuation of risk.

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Facilitation of Sexual Behavior and Enhanced Dopamine Efflux in the Nucleus Accumbens of Male Rats afterd-Amphetamine-Induced Behavioral Sensitization

Cited by 150 publications

References 50 publications

Sexual Behavior Induction of c-Fos in the Nucleus Accumbens and Amphetamine-Stimulated Locomotor Activity Are Sensitized by Previous Sexual Experience in Female Syrian Hamsters

Sexual Behavior Induction of c-Fos in the Nucleus Accumbens and Amphetamine-Stimulated Locomotor Activity Are Sensitized by Previous Sexual Experience in Female Syrian Hamsters

Interference with AMPA receptor endocytosis: effects on behavioural and neurochemical correlates of amphetamine sensitization in male rats

Risk preference following adolescent alcohol use is associated with corrupted encoding of costs but not rewards by mesolimbic dopamine

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