Facilitation of polyoma tumor growth in rats by blocking sera and tumor eluate

Bansal, S. C.; Hargreaves, Roseanna; Sjögren, Hans

doi:10.1002/ijc.2910090112

Cited by 92 publications

(17 citation statements)

References 27 publications

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“…Currie and Basham (1972) have demonstrated that washing of lymphocytes from cancer patients increased their cytotoxic activity; subsequent incubation of the prewashed lymphocytes with autologous serum abolished this reactivity. The anergy of local lymphocytes in our system (Flannery et al, 1973) (Bansal, Hargreaves and Sj6gren, 1972;Ran and Witz, 1972;Sjogren et al, 1972). Others Cohen, Millar and Ketcham, 1972) have demonstrated blocking by incubation of tumour cells with serum but failed to show inhibition by similar incubation of lymphocytes.…”

Section: Discussionmentioning

confidence: 78%

Immune Response to a Synegeneic Rat Tumour: Evolution of Serum Cytotoxicity and Blockade

Flannery¹,

Chalmers²,

Rolland³

et al. 1973

Br J Cancer

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Summary.-The development of serum factors by Wistar rats during the growth of a syngeneic squamous cell carcinoma has been investigated to clarify the nature of the local lymphocyte anergy reported previously in this system. Sera from tumour bearing animals were tested for cytotoxicity against tumour cells by in vitro microassay, and their ability to inhibit cell mediated cytotoxicity was also studied. Serum cytotoxicity was first detected after 2 weeks of tumour growth, reaching a peak at 4 weeks and then declining. Inhibitory activity was found only in the sera of animals with advanced tumours. Anti-tumour antibody either in the sera or bound-to tumour cells was not detected by immunofluorescence techniques. No evidence of general immunological debilitation was found, the animals showing normal immune responses to sheep erythrocytes and killed Brucella abortus organisms throughout tumour growth. Serum inhibitory factors may be responsible for the decline in antitumour immunoreactivity and the local lymphocyte anergy observed in tumour bearing hosts.

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Section: Discussionmentioning

confidence: 78%

Immune Response to a Synegeneic Rat Tumour: Evolution of Serum Cytotoxicity and Blockade

Flannery¹,

Chalmers²,

Rolland³

et al. 1973

Br J Cancer

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“…It has been shown that blocking sera facilitated tumour growth (Takasugi & Klein, 1971;Bansal et al, 1972) and prevented immune lymphocytes from killing tumour cells in cytotoxicity assays. But blocking factors were only detectable in sera from individuals bearing tumours; they disappeared rapidly after tumour excision (Sjogren and Baldwin et al, 1973).…”

Section: Resultsmentioning

confidence: 99%

Serological response to intracaecal injections of antigenic mouse tumour cells

Laursen¹

1978

Br J Cancer

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Summary.-Immunofluorescence studies of sera from mice with induced enhancement of tumour growth demonstrated that these sera contained factors ("interfering factors") which in an apparently competitive manner interfered with the subsequent binding of specific antibodies to antigenic sites on the tumour-cell membrane. The factors were tumour-specific but lacked some of the immunoglobulin determinants. They could not be detected by polyvalent FITC-antimouse y-globulin. Interfering factors did not seem to be related to IgA or IgE. They were demonstrable in sera from tumour -free animals without growing tumours, thus differing from the tumourspecific "blocking factors".

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“…The presence of soluble HL-A antigens in serum has been reported by Charlton and Zmijewski [26]. Bansal et al [27] have reported that low pH eluates of polyoma induced rat fibrosarcoma cells can enhance the growth of homologous tumor in vivo. This was most likely due t o enhancing antibody or antigen-antibody complexes.…”

Section: The Presence Of Immunogens In the Ascites Fluidmentioning

confidence: 88%

Escape of TA3 tumors from allogeneic immune rejection: theory and experiments

et al. 1974

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A factor promoting tumor growth in allogeneic mice was found in the ascites fluid of TA3-Ha tumor-bearing mice. Preliminary attempts t o isolate this factor resulted in a preparation (P3), devoid of free immunoglobulins or serum proteins, which had enhanced action in promoting tumor growth in vivo. Electron microscopy showed that the P3 preparation is of membranous origin. Biochemical assays for membrane marker enzymes were positive. 5'-Nucleotidase and alkaline a-glycerophosphatase activity was found. Chemical and gas-liquid chromatographic analysis of long-chain carboxylic acids present in the tumor cell membrane and in the P 3 revealed the presence of fatiy acids in almost identical ratios in both preparations, again indicating the membranous character of P3.The P3 preparation as well as the ascites fluid have immunogenic properties. They could induce immune tolerance if injected neonatally and the P3 preparation could immunize against the TA3-Ha tumor if injected intramuscularly or subcutaneously into adult mice. It had no effect if injected intravenous- A working hypothesis has been proposed according t o which TA3-Ha tumor cells produce highly reactive membranous decay products which intercept incoming immunocytes o r immunoglobulins before they can reach their targets o n living tumor cells. Whether this self protection of TA3 ascites tumors can be applied to other tumors remains t o be investigated.ly.

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Facilitation of polyoma tumor growth in rats by blocking sera and tumor eluate

Cited by 92 publications

References 27 publications

Immune Response to a Synegeneic Rat Tumour: Evolution of Serum Cytotoxicity and Blockade

Immune Response to a Synegeneic Rat Tumour: Evolution of Serum Cytotoxicity and Blockade

Serological response to intracaecal injections of antigenic mouse tumour cells

Escape of TA3 tumors from allogeneic immune rejection: theory and experiments

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