Facilitation of Motor Evoked Potentials in Response to a Modified 30 Hz Intermittent Theta-Burst Stimulation Protocol in Healthy Adults

Hosel, Katarina; Tremblay, François

doi:10.3390/brainsci11121640

Cited by 4 publications

(2 citation statements)

References 55 publications

(84 reference statements)

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“…In the present study, MEPs of a single subject at every delay were analyzed from 8 backward balance perturbation trials and the average value was calculated (7 -8 trials) after removing outliers. To the best of our knowledge, there is only one previous TMS study that has used this method (Hosel and Tremblay, 2021). Since ICC of MEPs demonstrated good-to-excellent within-session (between trials) reliability, calculating average MEP amplitude from 8 TMS stimulation trials and removing outlier MEPs beyond 2.5 SD (maximum one outlier in the present results) could be considered as sufficient in reducing MEP between-trial variability and producing a reliable TMS procedure in corresponding balance perturbation tasks.…”

Section: Discussionmentioning

confidence: 99%

Reliability of transcranial magnetic stimulation and H-reflex measurement during balance perturbation tasks

Avela

Kidgell

et al. 2022

Front. Physiol.

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Following ankle movement, posterior balance perturbation evokes short- (SLR ∼30–50 ms), medium- (MLR ∼50–60 ms), and long-latency responses (LLR ∼70–90 ms) in soleus muscle before voluntary muscle contraction. Transcranial magnetic stimulation (TMS) and Hoffmann-reflex (H-reflex) measurements can provide insight into the contributions of corticospinal and spinal mechanisms to each response. Motor evoked potential (MEP) and H-reflex responses have shown good reliability in some dynamic muscle contraction tasks. However, it is still unclear how reliable these methods are in dynamic balance perturbation and corticospinal modulation during long amplitude balance perturbation tasks. 14 subjects completed two test sessions in this study to evaluate the reliability of MEPs, H-reflex, and corticospinal modulation during balance perturbation. In each session, the balance perturbation system operated at 0.25 m/s, accelerating at 2.5 m/s2 over 0.3 m displacement. MEPs and H-reflexes were elicited in the right leg soleus muscle at four delays after ankle movement (10 ms, 40 ms, 80 ms, and 140 ms), respectively. Test-retest reliability of MEP and H-reflex amplitudes were assessed via intraclass correlation coefficients (ICC) both between- and within-session. Between-session test-retest reliability for MEPs was excellent (ICC = 0.928–0.947), while H-reflex demonstrated moderate-to-good reliability (ICC = 0.626–0.887). Within-session reliability for both MEPs and H-reflex was excellent (ICC = 0.927–0.983). TMS and H-reflex measurements were reliable at different delays after perturbation between- and within-sessions, which indicated that these methods can be used to measure corticospinal excitability during balance perturbation.

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Section: Discussionmentioning

confidence: 99%

Reliability of transcranial magnetic stimulation and H-reflex measurement during balance perturbation tasks

Avela

Kidgell

et al. 2022

Front. Physiol.

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show abstract

“…Beginning with central stimulation, a study by Hosel and Tremblay [ 2 ] presented a neurophysiological investigation on the modulation of motor-evoked potentials (MEPs) in 19 healthy individuals using a modified version of intermittent theta burst stimulation (iTBS), which is a special form of repetitive transcranial magnetic stimulation (rTMS). MEP facilitation was observed in 68.42% of cases following a single session of 30 Hz/6 Hz iTBS, suggesting the neuromodulatory potential of this paradigm.…”

Section: Neurophysiology and Neurostimulationmentioning

confidence: 99%