“…In addition, the combination therapy eliminates the need to wait for 5-10 min between drug instillations to avoid the dilution of drugs or washout from the cul-de-sac. 21 Also, decreasing the frequency of medication can reduce the utilization of the nursing staff, and each instilled drop had sufficient pharmacologic effect, improving the treatment efficiency. The advantages of combination therapy, such as effectiveness, efficiency, and convenience, compared with concomitant therapy suggest that combinations of drugs should be recommended to replace the application of multiple drugs.…”