Facilitating lifestyle changes to manage menopausal symptoms in women with breast cancer

Anderson, Debra; Seib, Charrlotte; McCarthy, Alexandra; Yates, Patsy; Porter-Steele, Janine; McGuire, Amanda; Young, Leonie S.

doi:10.1097/gme.0000000000000421

Cited by 36 publications

(39 citation statements)

References 51 publications

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“…Two interventions involving telephone counseling were beneficial, with one reporting a significantly improved feeling of sexual attractiveness and the other finding a trend toward improved feeling of sexual desirability (15, 27). Another intervention, employing clinic appointments and journaling, resulted in significantly improved sexual function for participants (16). Taken together, these studies support the continued investigation of physical activity interventions to improve sexual health in ECS.…”

Section: Discussionmentioning

confidence: 99%

“…Cross-sectional studies investigating middle-aged and perimenopausal women without a history of cancer have indicated a correlation between exercise and sexual desire (13, 14). In breast cancer survivors, randomized controlled trials of physical activity interventions have demonstrated sexual health benefits (15, 16). Although breast and endometrial cancers are both obesity-driven diseases, the effects of interventions on breast cancer survivors cannot necessarily be generalized to ECS given the differences in anatomic site and potential variances in psychological factors.…”

Section: Introductionmentioning

confidence: 99%

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Sexual health of endometrial cancer survivors before and after a physical activity intervention: A retrospective cohort analysis

Armbruster

Song

Bradford

et al. 2016

Gynecologic Oncology

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Objective Sexual dysfunction is common in endometrial cancer survivors (ECS). Our group previously tested a six-month exercise intervention in ECS. We performed a secondary analysis to determine intervention's impact on sexual health. Methods We studied 100 post-treatment Stage I-IIIa sedentary ECS who participated in a non-controlled, single-arm, home-based exercise intervention utilizing telephone counseling, printed material, and pedometers. Quality-of-life and physical activity measures were collected at baseline and six months. Sexual function (SF) and sexual interest (SI) scores were extracted from the QLACS questionnaire. Results Baseline SF and SI were lower in survivors with less than a four-year college degree (P < 0.001). Baseline SI was higher in survivors who were married or living with a significant other (P = 0.012). No significant differences in SF or SI were observed based on obesity status, race, time since diagnosis, or treatment type. Post-intervention, mean SF score improved (P = 0.002), 51% of participants had improved SI, and 43% had improved SF. When controlled for age and time since diagnosis, a one-hour increase in weekly physical activity was associated with a 6.5% increased likelihood of improved SI (P = 0.04). Increased physical activity was not associated with improved SF. Conclusions Although causation cannot be determined in this study, the correlation between receipt of an exercise intervention and improved sexual health for ECS is a novel finding. This finding suggests a role for physical activity as a strategy to improve the sexual health of ECS, which our group is examining in a larger prospective study.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sexual health of endometrial cancer survivors before and after a physical activity intervention: A retrospective cohort analysis

Armbruster

Song

Bradford

et al. 2016

Gynecologic Oncology

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“…The WWRP comprises a series of research projects that broadly aim to increase understanding of women's health and lifestyle behaviours and to develop effective empirically-based interventions targeting a reduction of tobacco smoking, hazardous alcohol use, increasing water intake, improving diets and increasing physical activity. This analysis also includes individual-level baseline data from 969 Australian women from the Healthy Aging of Women Study (HOW) [26][27][28] ; the Pink Women's Wellness Program 29 ; the Bluebox Study 30 ; and the Women's Wellness After Cancer Program (WWACP, trial ongoing). For the analysis, only women aged 40-63 years were included (this age range represents the expected age range at natural menopause ± 5 years).…”

Section: Participants and Proceduresmentioning

confidence: 99%

“…The study procedures and recruitment details have been outlined extensively in previous papers [26][27][28][29][30][31][32][33] . Briefly, the HOW is a longitudinal observational study of women randomly selected from the electoral roll that commenced in 2001.…”

Section: Participants and Proceduresmentioning

confidence: 99%

Menopausal symptom clusters and their correlates in women with and without a history of breast cancer: a pooled data analysis from the Women's Wellness Research Program

et al. 2017

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“…Of these, 330 were excluded; 59 included fewer than 20 women per study arm and 54 were not an RCT; 126 did not clearly state a sample size calculation; 52 did not measure vasomotor symptoms as the primary outcome; 39 were secondary analysis. Following these exclusions, 214 RCT were included…”

Section: Resultsmentioning

confidence: 99%

Variation in menopausal vasomotor symptoms outcomes in clinical trials: a systematic review

Iliodromiti

Wang

Lumsden

et al. 2019

BJOG

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Background There is substantial variation in how menopausal vasomotor symptoms are reported and measured among intervention studies. This has prevented meaningful comparisons between treatments and limited data synthesis. Objectives To review systematically the outcome reporting and measures used to assess menopausal vasomotor symptoms from randomised controlled trials of treatments. Search strategy We searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials from inception to May 2018. Selection criteria Randomised controlled trials with a primary outcome of menopausal vasomotor symptoms in women and a sample size of at least 20 women per study arm. Data collection and analysis Data about study characteristics, primary vasomotor‐related outcomes and methods of measuring them. Main results The search identified 5591 studies, 214 of which were included. Forty‐nine different primary reported outcomes were identified for vasomotor symptoms and 16 different tools had been used to measure these outcomes. The most commonly reported outcomes were frequency (97/214), severity (116/214), and intensity (28/114) of vasomotor symptoms or a composite of these outcomes (68/214). There was little consistency in how the frequency and severity/intensity of vasomotor symptoms were defined. Conclusions There is substantial variation in how menopausal vasomotor symptoms have been reported and measured in treatment trials. Future studies should include standardised outcome measures which reflect the priorities of patients, clinicians, and researchers. This is most effectively achieved through the development of a Core Outcome Set. This systematic review is the first step towards development of a Core Outcome Set for menopausal vasomotor symptoms. Tweetable summary Menopausal hot flushes and night sweats have been reported in 49 different ways in clinical research. A core outcome set is urgently required.

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Facilitating lifestyle changes to manage menopausal symptoms in women with breast cancer

Cited by 36 publications

References 51 publications

Sexual health of endometrial cancer survivors before and after a physical activity intervention: A retrospective cohort analysis

Sexual health of endometrial cancer survivors before and after a physical activity intervention: A retrospective cohort analysis

Menopausal symptom clusters and their correlates in women with and without a history of breast cancer: a pooled data analysis from the Women's Wellness Research Program

Variation in menopausal vasomotor symptoms outcomes in clinical trials: a systematic review

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