Facilitated ion transport in a biomembrane model. Artificial ion channels as pores in dihexadecyl phosphate vesicles

Abstract

An artificial ion channel, composed of stacks of crown ether rings, forms a pore in bilayers of dihexadecyl phosphate vesicles and facilitates the transmembranous transport of cobalt ions.

Conformational and orientation studies of artificial ion channels incorporated into lipid bilayers

“…[5][6][7][8][9][10][11][12] Some successful approach gave compounds that showed single-channel activity. [13][14][15][16][17][18][19][20][21][22][23][24][25] In our laboratory, we have described a general strategy to prepare supramolecular devices having a predictable structure 26 using polypeptides as frameworks.…”

Selective ion permeation across membranes containing crown ethers with steroid moieties

“…2 was synthesized from 4'-(2-carboxyvinyl) benzo-15-crown-5 '') as described below. 4'-(2-carboxyvinyl)benzo-l5-crown-5 (4,O g; 12 mmol) was reduced at room temperature by hydrogen in a mixed solvent of ethanol (200 mL) and acetic acid (100 mL) in the presence of Pd/C (3,O 9). After filtration, the filtrate was concentrated in vacuo.…”

Chiral discrimination of a helically organized crown ether array parallel to the helix axis of polyisocyanate

“…For highly sensitive and selective interactions, crown ether has a great advantage in comparison with other binding groups because crown ether allows ideal design toward targeted guest molecules, promising a guest‐specific binding ability 18, 19. Therefore, rapidly increasing attention has been paid to the synthesis and characterization of helical polymers with crown ether 20–26. Roks and Nolte22 revealed that polyisocyanide bearing crown ether, in which the crown ether rings were cofacially stacked on the basis of the rigid 4 1 helical structure, acted as an ion channel.…”