Facile Way to Prepare a Porous Molecular Imprinting Lock for Specifically Recognizing Oxytetracyclin Based on Coordination

Abstract

Molecularly imprinted polymers (MIPs) are a kind of synthetic receptor-like materials. They have drawn more and more attention in the past decades. In this work, a facile method was developed to prepare porous magnetic MIPs utilizing metal coordination. The preparation is simply done using conventional oil-in-water emulsifier-free emulsion technology by mixing poly(styrene-co-itaconic acid), oxytetracyclin (OTC), Cu(II), and Fe 3 O 4 magnetic fluid in one pot with a reaction time of 3 h. The product shows high specificity and selectivity toward OTC, as well as an excellent saturation adsorption capacity (62.567 mg/g). Emphasizing that the imprinting factor is 29, which is the highest one among the reported MIPs to the best of our knowledge. Combined with high-performance liquid chromatography, it was used successfully to determine OTC in pork liver, one of the most complex biosamples. Recoveries are higher than 91.0% with relative standard deviations less than 4.5% at three spiked levels (n = 3). All evidence testifies that the MIPs based on metal coordination show excellent recognition selectivity and specificity, as well as large rebinding capacity. The strategy holds promise as a reliable, extensible, and versatile way for preparing a metal ion-mediated molecular-imprinting polymer.

One-Pot Strategy as a Green and Rapid Method to Fabricate Magnetic Molecularly Imprinted Nanoparticles for Selective Capture of Sulfonylurea Herbicides

“…Table summarizes the comparison about the step, time, and organic solvent consumptions in the preparation of MINs in our study and previous methods. As shown, three to five steps are employed to fabricate MINs in existing studies. − ,− Thus, a long preparation period should be spent and a large amount of organic solvent should be employed. However, in the present study, a convenient one-pot method is utilized to prepare MINs.…”

“…To reduce the synthesized steps and shorten the preparation period, efforts have been made to optimize the fabrication technology for MINs. Recently, Feng’s group proposed a facile method to synthesize porous magnetic imprinted polymer utilizing metal coordination . In their study, poly (styrene- co -itaconic acid), oxytetracyclin (OTC), Cu­(II), and Fe 3 O 4 magnetic fluid (acted as a magnetic core) were mixed in one-pot and oil-in-water emulsifier-free emulsion technology was employed to prepare the MINs.…”

“…Recently, Feng's group proposed a facile method to synthesize porous magnetic imprinted polymer utilizing metal coordination. 19 In their study, poly (styrene-coitaconic acid), oxytetracyclin (OTC), Cu(II), and Fe 3 O 4 magnetic fluid (acted as a magnetic core) were mixed in one-pot and oil-in-water emulsifier-free emulsion technology was employed to prepare the MINs. The synthesized adsorbent presented excellent recognition selectivity to OTC.…”

Microcystins Detection Methods: A Focus on Recent Advances Using Molecularly Imprinted Polymers

“…Molecularly imprinted polymers (MIPs) have emerged as powerful analytical tools for MCs detection. Molecular imprinting refers to the design and production of highly cross-linked polymers called MIPs. , These tailor-made materials possess high and specific molecular recognition capabilities toward an imprint molecule, so-called target molecule, or template. − This approach had been used to produce materials mimicking natural receptors . MIPs are synthesized by copolymerization of functional monomers and cross-linker in the presence of a template.…”

“…111−113 This approach had been used to produce materials mimicking natural receptors. 114 MIPs are synthesized by copolymerization of functional monomers and cross-linker in the presence of a template. Functional monomers are chosen empirically or computationally, based on the ability to selectively interact with the functional groups of the target molecule.…”