Facile, tunable, and SERS-enhanced HEPES gold nanostars

Saverot, Scott-Eugene; Geng, Xi; Leng, Weinan; Vikesland, Peter J.; Grove, Tijana Ž.; Bickford, Lissett R.

doi:10.1039/c6ra00450d

Cited by 38 publications

(46 citation statements)

References 31 publications

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“…In the absence of protein, nanoparticle formation was observed spontaneously in the absence of irradiation (Figure ) and color change of the solution could be seen after approximately 20 min. This result was expected as HEPES is known as a weak reducer of gold ions and has been used to produce gold nanoparticles (Habib, Tabata, & Wu, ; Saverot et al, ; Xie, Zhang, Lee, & Wang, ). This reduction of gold by HEPES has been attributed to the generation of nitrogen‐centered cationic free radicals in the presence of gold salt (Habib et al, ).…”

Section: Resultsmentioning

confidence: 69%

Protein‐facilitated gold nanoparticle formation as indicators of ionizing radiation

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et al. 2019

Biotech & Bioengineering

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The use of X-ray radiation in radiotherapy is a common treatment for many cancers.Despite several scientific advances, determination of radiation delivered to the patient remains a challenge due to the inherent limitations of existing dosimeters including fabrication and operation. Here, we describe a colorimetric nanosensor that exhibits unique changes in color as a function of therapeutically relevant radiation dose (3-15 Gy). The nanosensor is formulated using a gold salt and maltose-binding protein as a templating agent, which upon exposure to ionizing radiation is converted to gold nanoparticles. The formation of gold nanoparticles from colorless precursor salts renders a change in color that can be observed visually. The dose-dependent multicolored response was quantified through a simple ultraviolet-visible spectrophotometer and the peak shift associated with the different colored dispersions was used as a quantitative indicator of therapeutically relevant radiation doses. The ease of fabrication, visual color changes upon exposure to ionizing radiation, and quantitative read-out demonstrates the potential of protein-facilitated biomineralization approaches to promote the development of next-generation detectors for ionizing radiation.

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Section: Resultsmentioning

confidence: 69%

Protein‐facilitated gold nanoparticle formation as indicators of ionizing radiation

Thaker

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Bista

et al. 2019

Biotech & Bioengineering

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“…Therefore, over the past two decades, remarkable progress has been made in the colloidal synthesis of a myriad of anisotropic NPs including nanowires, 9,10 nanorods, 11 nanoprisms 12,13 and branched NPs. [14][15][16] For example, the advent of Ag nanoprisms in early 2000 has sparked tremendous research interest in the subject of 2D platelike plasmonic nanostructures. 12 Discrete dipole approximation (DDA) simulation and UV-Vis spectral investigations have unambiguously confirmed dual LSPR modes corresponding to the dipole and quadrupole.…”

Section: Introductionmentioning

confidence: 99%

Protein-aided formation of triangular silver nanoprisms with enhanced SERS performance

et al. 2016

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“…[1][2][3][4][5] Liver injury, usually induced by toxic substances, viral infection and drug abuse, is a common clinical disease. [1][2][3][4][5] Liver injury, usually induced by toxic substances, viral infection and drug abuse, is a common clinical disease.…”

Section: Introductionmentioning

confidence: 99%

Gold nanoflowers modified ITO glass as SERS substrate for carbon tetrachloride-induced acute liver injury in vitro detection

et al. 2016

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For the sensitive and convenient detection of acute liver injury, several methods and materials have been developed. However, it is still a challenge to obtain sensitive, simple detection techniques for acute liver injury. Here, based on a gold nanoflowers (GNFs) modified substrate and 6-mercaptopurine (6-MP) as a surface-enhanced Raman scattering (SERS) signal molecule, a novel method was developed for monitoring carbon tetrachloride (CCl 4 )-induced acute liver injury of mice. Glutathione (GSH)-triggered and glutathione-s-transferase (GST)-accelerated the turn-off SERS behavior of 6-MP was studied on the GNFs substrate. We found that GSH-triggered GST-accelerated turn-off behavior of 6-MP on the GNFs substrate surface in buffer systems. In CCl 4 -induced acute liver injury mice tissue extracts without adding GST, the turn-off behavior of 6-MP was also accelerated, the detection intensity from 10 5 down to 10 3 counts for 6-MP. The SERS results confirmed that GNFs substrate exhibited strong SERS signal intensity, excellent stability in complex biological environment and detection clinical sample. This study provides a new, rapid and sensitive approach for analysis of trace amounts detection based on SERS coupled with GNFs substrate, which has great potential for analysis of surface chemical properties indicating its potential applicability in biological and biomedical research.

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Facile, tunable, and SERS-enhanced HEPES gold nanostars

Abstract: The facile, green synthesis of gold nanostars (AuNSs) with tunable branch lengths for SERS applications.

Cited by 38 publications

References 31 publications

Protein‐facilitated gold nanoparticle formation as indicators of ionizing radiation

Protein‐facilitated gold nanoparticle formation as indicators of ionizing radiation

Protein-aided formation of triangular silver nanoprisms with enhanced SERS performance

Gold nanoflowers modified ITO glass as SERS substrate for carbon tetrachloride-induced acute liver injury in vitro detection

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