Facile synthetic route to Fe3O4/silica nanocomposites pillared clay through cationic surfactant-aliphatic acid mixed system and application for magnetically controlled drug release

Mao, Huihui; Zhu, Kongnan; Liu, Xiaoting; Yao, Chao; Kobayashi, Motoyoshi

doi:10.1016/j.micromeso.2015.11.045

Cited by 21 publications

(2 citation statements)

References 38 publications

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“…1b). 47 In this route, oleic acid-formed organics could cooperate with cationic surfactants to generate interlayered mixed micelles, further ensuring that interlayered Fe 3 O 4 formed with an outstanding dispersion and mesoporous structure and valid loading of IBU. Analogously, by reason of magnetomechanical force resultant particle aggregation, the release quantity of IBU was only 68.2–80.1% under a magnetic field of 150 mT for 10 h, while that without a magnetic field was 90%.…”

Section: Magnetomechanical Force For Drug Controlled Releasementioning

confidence: 99%

Magnetomechanical force: an emerging paradigm for therapeutic applications

Yao

Zhang

et al. 2022

J. Mater. Chem. B

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Section: Magnetomechanical Force For Drug Controlled Releasementioning

confidence: 99%

Magnetomechanical force: an emerging paradigm for therapeutic applications

Yao

Zhang

et al. 2022

J. Mater. Chem. B

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“…Therefore, alternative approaches are being pursued for the fabrication of AgNP composites by employing graphene [ 23 ], polymers [ 24 ], plant extract [ 16 ], clay [ 25 ], polysaccharide [ 26 ], and fatty acid [ 27 ]. The main disadvantages related to these nanohybrids were incomplete antibacterial efficacy [ 24 ], rapid release of active components [ 28 ], cost and time-ineffective operation [ 29 ], aggregation affinity [ 30 ], and higher cytotoxicity [ 31 , 32 , 33 ]. On top of this, α-aminophosphonates (α-APs), as a significant class of organophosphorus compounds, were remarkably exploited in several amplified domains [ 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Docking Study of Novel Thioureidophosphonate-Incorporated Silver Nanocomposites as Potent Antibacterial Agents

et al. 2023

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Newly synthesized mono- and bis-thioureidophosphonate (MTP and BTP) analogues in eco-friendly conditions were employed as reducing/capping cores for 100, 500, and 1000 mg L−1 of silver nitrate. The physicochemical properties of silver nanocomposites (MTP(BTP)/Ag NCs) were fully elucidated using spectroscopic and microscopic tools. The antibacterial activity of the nanocomposites was screened against six multidrug-resistant pathogenic strains, comparable to ampicillin and ciprofloxacin commercial drugs. The antibacterial performance of BTP was more substantial than MTP, notably with the best minimum inhibitory concentration (MIC) of 0.0781 mg/mL towards Bacillus subtilis, Salmonella typhi, and Pseudomonas aeruginosa. Among all, BTP provided the clearest zone of inhibition (ZOI) of 35 ± 1.00 mm against Salmonella typhi. After the dispersion of silver nanoparticles (AgNPs), MTP/Ag NCs offered dose-dependently distinct advantages over the same nanoparticle with BTP; a more noteworthy decline by 4098 × MIC to 0.1525 × 10−3 mg/mL was recorded for MTP/Ag-1000 against Pseudomonas aeruginosa over BTP/Ag-1000. Towards methicillin-resistant Staphylococcus aureus (MRSA), the as-prepared MTP(BTP)/Ag-1000 displayed superior bactericidal ability in 8 h. Because of the anionic surface of MTP(BTP)/Ag-1000, they could effectively resist MRSA (ATCC-43300) attachment, achieving higher antifouling rates of 42.2 and 34.4% at most optimum dose (5 mg/mL), respectively. The tunable surface work function between MTP and AgNPs promoted the antibiofilm activity of MTP/Ag-1000 by 1.7 fold over BTP/Ag-1000. Lastly, the molecular docking studies affirmed the eminent binding affinity of BTP over MTP—besides the improved binding energy of MTP/Ag NC by 37.8%—towards B. subtilis-2FQT protein. Overall, this study indicates the immense potential of TP/Ag NCs as promising nanoscale antibacterial candidates.

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