Facile synthesis of β-cyclodextrin-cyclophosphamide complex-loaded hydrogel for controlled release drug delivery

Zafar, Nadiah; Mahmood, Asif; Sarfraz, Rai Muhammad; Ijaz, Hira; Ashraf, Muhammad Umar; Mehr, Sidra

doi:10.1007/s00289-022-04567-7

Cited by 5 publications

(5 citation statements)

References 42 publications

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“…In the case of the NSs-CYC formulation, the characteristic sharp peaks of CYC were noticeably masked or diminished by the NSs matrix, confirming amorphization of the drug. Crystallinity hinders the solubility of a substance, while an amorphous formulation enhances solubility and dissolution rates resulting from higher levels of free Gibbs energy and higher molecular mobility. , …”

Section: Resultsmentioning

confidence: 65%

“…Crystallinity hinders the solubility of a substance, while an amorphous formulation enhances solubility and dissolution rates resulting from higher levels of free Gibbs energy and higher molecular mobility. 57,58 The CYC, NSs, and NSs-CYC samples were characterized and analyzed by Raman spectroscopy and FT-IR (Figure 5). After obtaining the inclusion complex, Raman and FT-IR spectra can be compared to NSs to observe any differences ascribed to the chemical interaction.…”

Section: Characterization Of Nss-cyc Inclusionmentioning

confidence: 99%

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Controlled Release of the Anticancer Drug Cyclophosphamide from a Superparamagnetic β-Cyclodextrin Nanosponge by Local Hyperthermia Generated by an Alternating Magnetic Field

Salazar Sandoval,

Díaz-Saldívar,

Araya

et al. 2024

ACS Appl. Mater. Interfaces

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A β-cyclodextrin (β-CD) nanosponge (NS) was synthesized using diphenyl carbonate (DPC) as a cross-linker to encapsulate the antitumor drug cyclophosphamide (CYC), thus obtaining the NSs-CYC system. The formulation was then associated with magnetite nanoparticles (MNPs) to develop the MNPs-NSs-CYC ternary system. The formulations mentioned above were characterized to confirm the deposition of the MNPs onto the organic matrix and that the superparamagnetic nature of the MNPs was preserved upon association. The association of the MNPs with the NSs-drug complex was confirmed through field emission scanning electron microscopy, energy dispersive spectroscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, dynamic light scattering, ζ-potential, atomic absorption spectroscopy, X-ray powder diffraction, selected area electron diffraction, and vibrating-sample magnetometer. The superparamagnetic properties of the ternary system allowed the release of CYC by utilizing magnetic hyperthermia upon the exposure of an alternating magnetic field (AMF). The drug release experiments were carried out at different frequencies and intensities of the magnetic field, complying with the "Atkinson−Brezovich criterion". The assays in AMF showed the feasibility of release by controlling hyperthermia of the drug, finding that the most efficient conditions were F = 280 kHz, H = 15 mT, and a concentration of MNPs of 5 mg/mL. CYC release was temperature-dependent, facilitated by local heat generation through magnetic hyperthermia. This phenomenon was confirmed by DFT calculations. Furthermore, the ternary systems outperformed the formulations without MNPs regarding the amount of released drug. The MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assays demonstrated that including CYC within the magnetic NS cavities reduced the effects on mitochondrial activity compared to those observed with the free drug. Finally, the magnetic hyperthermia assays showed that the tertiary system allows the generation of apoptosis in HeLa cells, demonstrating that the MNPs embedded maintain their properties to generate hyperthermia. These results suggest that using NSs associated with MNPs could be a potential tool for a controlled drug delivery in tumor therapy since the materials are efficient and potentially nontoxic.

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Section: Resultsmentioning

confidence: 65%

Section: Characterization Of Nss-cyc Inclusionmentioning

confidence: 99%

Controlled Release of the Anticancer Drug Cyclophosphamide from a Superparamagnetic β-Cyclodextrin Nanosponge by Local Hyperthermia Generated by an Alternating Magnetic Field

Salazar Sandoval,

Díaz-Saldívar,

Araya

et al. 2024

ACS Appl. Mater. Interfaces

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“…It is most widely consumed in ophthalmic and topical preparations to facilitate drug delivery. It is also used in household products like lubricants, detergents, and cosmetics attributed to its watersoluble and nonionic nature [51]. It is soluble in hot water as well as cold water.…”

Section: Natrosol or Hydroxyethyl Cellulose (Hec)mentioning

confidence: 99%

“…Mechanism of gel formation is not fully understood; however, it can be explained regarding liquid-liquid phase separation. Hydrogels developed by using pure agarose are transparent, hard, elastic, and thermoreversible (Figure 9) [51].…”

Section: Agarosementioning

confidence: 99%

“…It is comprised of L-rhamnose, D-galactose, and L-galacturonic acid in its composition (Figure 12) [76]. In pharmaceutical industry, although its role has not been explored enough as hydrogel preparations, it is evaluated as an economical and effective binding agent in solid dosage forms [45,47,48], in forming controlled release matrices [49,50], for preparation of sustained release beads [51], microspheres [52,53], in mucoadhesive nasal gel [54] and in many other formulations as a sustained release polymer.…”

Section: Okra Gummentioning

confidence: 99%

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Polymeric Hydrogels and Nanogels: Classification, Development and Pharmaceutical Applications

Mahmood¹,

Ijaz²,

Sarfraz³

et al. 2023

Hydrogels and Nanogels - Applications in Medicine

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This book chapter give an overview of natural and synthetic polymeric moieties consumed for developing hydrogels and their types. Different properties of nanogels are the advancement of hydrogels characterized by nano-size range, stimuli-responsive swelling, and release. Stimuli responsiveness is imparted by the presence of a suitable monomer. A number of polymerization approaches are presented in the literature that are employed to prepare such networks. These systems are elastic, rubbery, nontoxic, and biocompatible and offer prolonged release of the drugs without chances of dose dumping. These types of networks have potential pharmaceutical, agricultural, food, and biotechnological applications in terms of controlled, prolonged, and targeted drug delivery, solubility enhancements, stimuli-dependent intelligent drug delivery, such as contact lenses, wound healing, etc. In the current chapter, we have tried to introduce hydrogels and microgels, their different types, the variety of polymers used to develop such carrier systems, approaches to develop such drug delivery systems, and their utilization in various sectors in addition to the pharmaceutical sector.

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Development of tamarind gum/β-CD-co-poly (MAA) hydrogels for pH-driven controlled delivery of capecitabine

Ahmed,

Mahmood,

Qureshi

et al. 2023

Polym. Bull.

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Facile synthesis of β-cyclodextrin-cyclophosphamide complex-loaded hydrogel for controlled release drug delivery

Cited by 5 publications

References 42 publications

Controlled Release of the Anticancer Drug Cyclophosphamide from a Superparamagnetic β-Cyclodextrin Nanosponge by Local Hyperthermia Generated by an Alternating Magnetic Field

Controlled Release of the Anticancer Drug Cyclophosphamide from a Superparamagnetic β-Cyclodextrin Nanosponge by Local Hyperthermia Generated by an Alternating Magnetic Field

Polymeric Hydrogels and Nanogels: Classification, Development and Pharmaceutical Applications

Development of tamarind gum/β-CD-co-poly (MAA) hydrogels for pH-driven controlled delivery of capecitabine

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