Facile Synthesis of Yolk–Shell Structured Inorganic–Organic Hybrid Spheres with Ordered Radial Mesochannels

Teng, Zhaogang; Wang, Shouju; Su, Xiaodan; Chen, Guotao; Liu, Ying; Luo, Zhimin; Luo, Wei; Tang, Yuxia; Ju, Huangxian; Zhao, Dongyuan; Lu, Guangming

doi:10.1002/adma.201400136

Cited by 185 publications

(160 citation statements)

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“…The Fourier transform infrared (FT‐IR) spectra of the PB, PB@PMO, and PB@PMO‐Ce6 display a vibration peak at 2070 cm −1 , which is assigned the CN groups of PB. The PB@PMO and PB@PMO‐Ce6 also show the Si—O—Si vibration peak at 1050 cm −1 , C—S band at 650 cm −1 , and C—H band at 2900 cm −1 ,21, 30 confirming that the PB nanoparticles are successfully coated with PMO shells. The C=O vibration peak at 1700 cm −1 in PB@PMO‐Ce6 further indicates successful Ce6 conjugation (Figure 1f) 31, 32, 33.…”

Section: Resultsmentioning

confidence: 67%

Oxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors

et al. 2018

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Oxygen (O2) plays a critical role during photodynamic therapy (PDT), however, hypoxia is quite common in most solid tumors, which limits the PDT efficacy and promotes the tumor aggression. Here, a safe and multifunctional oxygen‐evolving nanoplatform is costructured to overcome this problem. It is composed of a prussian blue (PB) core and chlorin e6 (Ce6) anchored periodic mesoporous organosilica (PMO) shell (denoted as PB@PMO‐Ce6). In the highly integrated nanoplatform, the PB with catalase‐like activity can catalyze hydrogen peroxide to generate O2, and the Ce6 transform the O2 to generate more reactive oxygen species (ROS) upon laser irradiation for PDT. This PB@PMO‐Ce6 nanoplatform presents well‐defined core–shell structure, uniform diameter (105 ± 12 nm), and high biocompatibility. This study confirms that the PB@PMO‐Ce6 nanoplatform can generate more ROS to enhance PDT than free Ce6 in cellular level (p < 0.001). In vivo, the singlet oxygen sensor green staining, tumor volume of tumor‐bearing mice, and histopathological analysis demonstrate that this oxygen‐evolving nanoplatform can elevate singlet oxygen to effectively inhibit tumor growth without obvious damage to major organs. The preliminary results from this study indicate the potential of biocompatible PB@PMO‐Ce6 nanoplatform to elevate O2 and ROS for improving PDT efficacy.

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Section: Resultsmentioning

confidence: 67%

Oxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors

et al. 2018

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“…However, pure PB nanoparticles cannot deliver drug for cancer chemotherapy because of their small micropores and limited loading capacity. Periodic mesoporous organosilicas (PMOs) synthesized via surfactant‐directed sol–gel process has been used for drug delivery because of their uniform and large mesopore size, high surface area, organic groups incorporated frameworks, and excellent biodegradation and biocompatibility 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43. Based on the unique features, we presumed that an imaging‐guided combination therapy strategy can be developed by intergating the advantages of PMO and PB.…”

Section: Introductionmentioning

confidence: 99%

Periodic Mesoporous Organosilica Coated Prussian Blue for MR/PA Dual‐Modal Imaging‐Guided Photothermal‐Chemotherapy of Triple Negative Breast Cancer

Tian

et al. 2016

Advanced Science

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Complete eradication of highly aggressive triple negative breast cancer (TNBC) remains a notable challenge today. In this work, an imaging‐guided photothermal‐chemotherapy strategy for TNBC is developed for the first time based on a periodic mesoporous organosilica (PMO) coated Prussian blue (PB@PMO) nanoplatform. The PB@PMOs have organic‐inorganic hybrid frameworks, uniform diameter (125 nm), high surface area (866 m2 g−1), large pore size (3.2 nm), excellent photothermal conversion capability, high drug loading capacity (260 µg mg−1), and magnetic resonance (MR) and photoacoustic (PA) imaging abilities. The MR and PA properties of the PB@PMOs are helpful for imaging the tumor and showing the accumulation of the nanoplatform in the tumor region. The bioluminescence intensity and tumor volume of the MDA‐MB‐231‐Luc tumor‐bearing mouse model demonstrate that TNBC can be effectively inhibited by the combined photothermal‐chemotherapy than monotherapy strategy. Histopathological analysis further reveals that the combination therapy results in most extensive apoptotic and necrotic cells in the tumor without inducing obvious side effect to major organs.

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“…Moreover, the incorporation of organic groups into the MON framework can substantially reduce the surface-exposed silanol groups, fortunately leading to extremely low hemolytic effects of MONs against red blood cells (RBCs). Ethenylene-bridged MONs, [ 132 ] ethane-bridged yolk-shell MONs, [ 131 ] and phenylene-bridged HMONs [ 66 ] have all exhibited an extremely low hemolytic percentage against RBCs even at a co-incubation concentration as high as 2000 µg mL −1 (Figure 12 a 3 ) attributed to the same reason regarding the reduction of silanol groups. [215][216][217] In contrast, the organic-inorganic hybrid composition of MONs can also lead to enhanced biodegradability of silica in the presence of a high content (ca.…”

Section: Reviewmentioning

confidence: 98%

Section: Structure/morphology Control Of Monsmentioning

confidence: 99%

“…Interestingly, asymmetric single-hole HMONs ( R = ethane) were synthesized by using solid silica NPs as the hard template simply by changing the synthetic conditions ( Figure 5 c). [ 130 ] Yolk-shell type HMONs with either solid silica ( Figure 5 d, R = ethane) [ 131 ] or upconversion NPs ( Figure 5 e, R = ethane) [ 130 ] as the core and mesoporous organosilica as the shell could be fabricated by this silica-templating approach, based on the fact that the methodology of coating nanocrystals with a silica layer is highly mature and feasible. [135][136][137] Importantly, colloidal MONs ( R = ethenylene) with an ethenylene-bridged silsesquioxane framework were successfully synthesized by adopting bis(triethoxysilyl)ethenylene (BTEE) as the organosilica precursor and CTAB as the SDAs under mild alkaline triethanolamine (TEA) solution.…”

Section: Reviewmentioning

confidence: 99%

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Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

2016

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Organic-inorganic hybrid materials aiming to combine the individual advantages of organic and inorganic components while overcoming their intrinsic drawbacks have shown great potential for future applications in broad fields. In particular, the integration of functional organic fragments into the framework of mesoporous silica to fabricate mesoporous organosilica materials has attracted great attention in the scientific community for decades. The development of such mesoporous organosilica materials has shifted from bulk materials to nanosized mesoporous organosilica nanoparticles (designated as MONs, in comparison with traditional mesoporous silica nanoparticles (MSNs)) and corresponding applications in nanoscience and nanotechnology. In this comprehensive review, the state-of-art progress of this important hybrid nanomaterial family is summarized, focusing on the structure/composition-performance relationship of MONs of well-defined morphology, nanostructure, and nanoparticulate dimension. The synthetic strategies and the corresponding mechanisms for the design and construction of MONs with varied morphologies, compositions, nanostructures, and functionalities are overviewed initially. Then, the following part specifically concentrates on their broad spectrum of applications in nanotechnology, mainly in nanomedicine, nanocatalysis, and nanofabrication. Finally, some critical issues, presenting challenges and the future development of MONs regarding the rational synthesis and applications in nanotechnology are summarized and discussed. It is highly expected that such a unique molecularly organic-inorganic nanohybrid family will find practical applications in nanotechnology, and promote the advances of this discipline regarding hybrid chemistry and materials.

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Facile Synthesis of Yolk–Shell Structured Inorganic–Organic Hybrid Spheres with Ordered Radial Mesochannels

Cited by 185 publications

References 55 publications

Oxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors

Oxygen‐Evolving Mesoporous Organosilica Coated Prussian Blue Nanoplatform for Highly Efficient Photodynamic Therapy of Tumors

Periodic Mesoporous Organosilica Coated Prussian Blue for MR/PA Dual‐Modal Imaging‐Guided Photothermal‐Chemotherapy of Triple Negative Breast Cancer

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

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