Facile synthesis of soybean phospholipid-encapsulated MoS2 nanosheets for efficient in vitro and in vivo photothermal regression of breast tumor

Abstract

Two-dimensional MoS 2 nanosheet has been extensively explored as a photothermal agent for tumor regression; however, its surface modification remains a great challenge. Herein, as an alternative to surface polyethylene glycol modification (PEGylation), a facile approach based on “thin-film” strategy has been proposed for the first time to produce soybean phospholipid-encapsulated MoS 2 (SP-MoS 2 ) nanosheets. By simply vacuum-treating MoS 2 nanosheets/soybean phospholipid/chloroform dispersion in a rotary evaporator, SP-MoS 2 nanosheet was successfully constructed. Owing to the steric hindrance of polymer chains, the surface-coated soybean phospholipid endowed MoS 2 nanosheets with excellent colloidal stability. Without showing detectable in vitro and in vivo hemolysis, coagulation, and cyto-/histotoxicity, the constructed SP-MoS 2 nanosheets showed good photothermal conversion performance and photothermal stability. SP-MoS 2 nanosheet was shown to be a promising platform for in vitro and in vivo breast tumor photothermal therapy. The produced SP-MoS 2 nanosheets featured low cost, simple fabrication, and good in vivo hemo-/histocompatibility and hold promising potential for future clinical tumor therapy.

Biological effects of molybdenum(IV) sulfide nanoparticles and microparticles in the rat after repeated intratracheal administration

“…On the other hand, PEGylated MoS 2 nanoflakes were shown to be hemocompatible, causing no hemolysis of isolated RBCs (less than 5% compared to the negative control) (Feng et al, 2015). Experiments performed on human RBCs exposed to MoS 2 nanosheets resulted in a hemolysis ratio under 5%, which is considered comparable to the physiological value (Li et al, 2016). An in vivo experiment on mice treated intravenously with PEGylated MoS 2 NPs showed no disturbances in the RBC count and HCT and HGB levels for up to 60 days of observation (Hao et al, 2017).…”

PEGylated MoSe2 Nanomaterials with Limited Oxidation via Femtosecond Laser Ablation for Photothermal Therapy

“…One way to attach biocompatible polymers is by using van der Waals forces. For example, soybean phospholipid, chitosan, poly­(ethylene glycol) (PEG), polyvinyl­pyrrolidone, polyethylenimine (PEI), and F-127 were attached to TMDC nanomaterials via van der Waals forces. ,,,− ,− Another way to conjugate TMDC nanomaterials with biocompatible polymers is through chemical bonds. TMDC nanomaterials can be conjugated with the polymers terminated with lipoic acid groups such as LA-PEG and LA-PEI by forming metal–sulfur bonds. ,,− All of these methods require hours or even days of stirring of nanomaterials and biocompatible polymers together.…”