Facile synthesis of red dual-emissive carbon dots for ratiometric fluorescence sensing and cellular imaging

Hu, Yang; Yang, Zixu; Lu, Xuan; Guo, Jiazhuang; Cheng, Rui; Zhu, Liangliang; Wang, Cai‐Feng; Chen, Su

doi:10.1039/d0nr00381f

Cited by 74 publications

(45 citation statements)

References 44 publications

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“…After characterized by fluorescence spectroscopy, the as-prepared CDs were all blue-emitting. Given that o -phenylenediamine ( o PD) is a universal precursor for the preparation of long-wavelength emission CDs, − the other four CDs (CDs 5–8) were synthesized via solvothermal treatment of the above four ILs and o PD, respectively (Scheme B). To our pleasant surprise, CDs-8 obtained by o PD and the IL BmimPF 6 were red-emitting and named R-CDs, while the other three CDs were yellow-emitting.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Ionic Liquid-Mediated Red-Emission Carbon Dots and Their Imaging Application in Living Cells

Zhang

Wang

et al. 2020

ACS Sustainable Chem. Eng.

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Recently, fluorescent carbon dots (CDs) have emerged as novel carbon nanomaterials in terms of their unique optical properties, robust chemical inertness, and excellent biocompatibility. However, synthesis of efficient red-emission carbon dots (R-CDs) remains highly desirable for sensing applications, especially in the field of bioimaging, on account of their deeper tissue penetration and greater bioimaging capability than CDs with low-wavelength emission. Herein, novel R-CDs are synthesized by one-step solvothermal treatment of o-phenylenediamine and the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate. The as-prepared R-CDs exhibit remarkable acidophilic ability; the results show that the fluorescence intensity of R-CDs at 620 nm decreases with increasing pH from 1.5 to 6.0 and with a linear response to the extreme acidity range of 1.5–4.0. Importantly, it is nearly 4.7-fold more sensitive to pH response than phosphate-mediated R-CDs. The proposed pH sensor is further applied to monitor extreme pH fluctuations in Escherichia coli (E. coli). Compared to those CDs with low-wavelength emission, ionic liquid-mediated R-CDs have lower energy, stronger penetrability, and greater bioimaging capabilities, making them more preferable for biological and medical applications. To our knowledge, no R-CDs mediated by ionic liquids are reported until now, which would open a new chapter in the synthesis of R-CDs with ionic liquids.

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Section: Introductionmentioning

confidence: 99%

Optimization of Ionic Liquid-Mediated Red-Emission Carbon Dots and Their Imaging Application in Living Cells

Zhang

Wang

et al. 2020

ACS Sustainable Chem. Eng.

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“…18 Moreover, a slight redshift was observed in Mn-CDs, in which two absorption bands were located at 262 and 425 nm. By measuring the FT-IR spectrum of Mn-CDs, the stretching vibration of CN (1501 cm −1 ) and the asymmetric stretching vibration of C−N (1226 cm −1 ) were observed, 21,22 demonstrating the presence of N element.…”

Section: Resultsmentioning

confidence: 99%

Manganese-Doped Carbon Dots with Redshifted Orange Emission for Enhanced Fluorescence and Magnetic Resonance Imaging

Sun

Zhao

et al. 2021

ACS Appl. Bio Mater.

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Metal-doped carbon dots (CDs) exhibited promising application in fluorescence and magnetic resonance (MR) imaging, but developing manganese-doped CDs (Mn-CDs) with long wavelength emission and enhanced MR performance is a challenge. Herein, using a one-step solvothermal method, Mn-CDs with redshifted orange emission and enhanced longitudinal relaxation were synthesized for fluorescence and MR imaging. The results indicated that the prepared Mn-CDs had a uniform size distribution, and the average size was 5 nm. Moreover, Mn-CDs possessed a stronger fluorescence performance than Mn-free CDs, and simultaneously, the emission wavelength can redshift from 542 nm (green emission) to 578 nm (orange emission), owing to the increasing N-doping. Because of the movement limit of Mn2+, Mn-CDs exhibited high T1-weighted MR imaging performance with a longitudinal relaxation rate of 12.69 mM–1·s–1. The in vivo experiments demonstrated their excellent fluorescence and MR imaging with safety and reliability. Therefore, the prepared Mn-CDs with orange emission can be an excellent candidate as a dual-modal nanoprobe for fluorescence and MR imaging.

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“…Owing to red emissive uorescence and good biocompatibility, the CNPs have great potential in the eld of bioimaging. [28][29][30][31][32] Different characterization techniques were used to properly analyse the structure, morphology, and optical properties of CNPs. The QY of CNPs is $6% in water and 87% in ethanol, showing that the uorescence of CNPs also depends on the type of solvent used.…”

Section: Discussionmentioning

confidence: 99%

Water stable, red emitting, carbon nanoparticles stimulate 3D cell invasion via clathrin-mediated endocytic uptake

et al. 2022

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Facile synthesis of red dual-emissive carbon dots for ratiometric fluorescence sensing and cellular imaging

Abstract: Carbon dots synthesized by the hydrothermal treatment of dicyandiamide and o-phenylenediamine in dilute H2SO4 exhibit efficient excitation-independent red dual-emission useful for ratiometric fluorescence sensing and cellular imaging.

Cited by 74 publications

References 44 publications

Optimization of Ionic Liquid-Mediated Red-Emission Carbon Dots and Their Imaging Application in Living Cells

Optimization of Ionic Liquid-Mediated Red-Emission Carbon Dots and Their Imaging Application in Living Cells

Manganese-Doped Carbon Dots with Redshifted Orange Emission for Enhanced Fluorescence and Magnetic Resonance Imaging

Water stable, red emitting, carbon nanoparticles stimulate 3D cell invasion via clathrin-mediated endocytic uptake

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