Facile synthesis of plasmonic zein nanoshells for imaging-guided photothermal cancer therapy

Chauhan, Deepak S.; Arunkumar, P.; Prasad, Rajendra; Mishra, Sumit; Reddy, B. Pradeep K.; De, Abhijit; Srivastava, Rohit

doi:10.1016/j.msec.2018.04.081

Cited by 28 publications

(19 citation statements)

References 55 publications

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“…In this context, because of their unique optical properties, noble metals such as gold (Au) and silver (Ag) exhibit a well-known photo-physical phenomenon called localized surface plasmon resonance, which contributes to enhancing their intrinsic photo-absorption characteristics 33–36. For this reason, they can be functionalized as image-guided photothermal cancer therapy37,38 or PTT agents due to their propensity to generate hyperthermia in tumor cells when irradiated with a laser light 39–41. Akin to Au- and Ag-structured nanoparticles, Ti 3 C 2 T x (MXene) nanocomposites, having transition metal element (titanium), exhibit a strong NIR absorption as well as subsequent light-to-heat conversion property resulting in photon-induced hyperthermia.…”

Section: Introductionmentioning

confidence: 99%

<p>Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene</p>

Hussein

Zagho

Rizeq

et al. 2019

IJN

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Purpose: Here, we fabricated two plasmonic 2D Ti 3 C 2 T x -based nanocomposites (Au/MXene and Au/Fe 3 O 4 /MXene) with similarly high anti-cancer photothermal therapy (PTT) capabilities, but with less in vivo toxicity than a pure MXene. Methods: Au/MXene was synthesized by in situ reduction of tetrachloroauric acid using NaBH 4 on Ti 3 C 2 T x flakes. For targeted PTT, magnetic Au/Fe 3 O 4 /MXene was synthesized via a reaction between freshly prepared magnetite Fe 3 O 4 NPs and MXene solution, followed by in situ integration of gold nanoparticles (AuNPs). Results: Morphological characterization by XRD, SEM, and TEM revealed the successful synthesis of Au/MXene and Au/Fe 3 O 4 /MXene. Both new composites exhibited a significant in vitro dose-dependent PTT effect against human breast cancer cells MCF7. Interestingly, in vivo acute toxicity assays using zebrafish embryos indicated that Au/MXene and Au/Fe 3 O 4 /MXene had less embryonic mortality (LC 50 ≫ 1000 µg/mL) than pure MXene (LC 50 =257.46 µg/mL). Conclusion: Our new Au/MXene and Au/Fe 3 O 4 /MXene nanocomposites could be safer and more suitable than the pure MXene for biomedical applications, especially when targeted PTT is warranted.

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Section: Introductionmentioning

confidence: 99%

<p>Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene</p>

Hussein

Zagho

Rizeq

et al. 2019

IJN

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“…Combining Zein with AuNPs to form ZAuNP hybrids is a relatively new research area, with only a few papers having been published to date [ 28 , 51 , 52 , 53 , 54 ]. While AuNPs have been combined with Zein in different forms (such as films, fibers, and nanoparticles), only one paper, to our knowledge, has considered the incorporation of AuNPs in ZNPs for tumor-killing purposes.…”

Section: Discussionmentioning

confidence: 99%

“…Two of the Zein characteristics that could be influenced due to the presence of the AuNPs are its zeta potential, as well as its secondary and tertiary profiles. Zein, at physiological pH, has a negative charge at approximately −35 mV; however, due to the presence of negatively charged AuNPs, there has been an observed further decrease in zeta potential when combining the two nanoparticles [ 30 , 52 ]. It has often been observed that changing the charge of the components, such as the small molecule’s charge, can influence the release characteristics of the system [ 27 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

Gold–Protein Composite Nanoparticles for Enhanced X-ray Interactions: A Potential Formulation for Triggered Release

et al. 2021

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Drug-delivery vehicles have been used extensively to modulate the biodistribution of drugs for the purpose of maximizing their therapeutic effects while minimizing systemic toxicity. The release characteristics of the vehicle must be balanced with its encapsulation properties to achieve optimal delivery of the drug. An alternative approach is to design a delivery vehicle that preferentially releases its contents under specific endogenous (e.g., tissue pH) or exogenous (e.g., applied temperature) stimuli. In the present manuscript, we report on a novel delivery system with potential for triggered release using external beam radiation. Our group evaluated Zein protein as the basis for the delivery vehicle and used radiation as the exogenous stimulus. Proteins are known to react with free radicals, produced during irradiation in aqueous suspensions, leading to aggregation, fragmentation, amino acid modification, and proteolytic susceptibility. Additionally, we incorporated gold particles into the Zein protein matrix to create hybrid Zein–gold nanoparticles (ZAuNPs). Zein-only nanoparticles (ZNPs) and ZAuNPs were subsequently exposed to kVp radiation (single dose ranging from 2 to 80 Gy; fractionated doses of 2 Gy delivered 10 times) and characterized before and after irradiation. Our data indicated that the presence of gold particles within Zein particles was correlated with significantly higher levels of alterations to the protein, and was associated with higher rates of release of the encapsulated drug compound, Irinotecan. The aggregate results demonstrated a proof-of-principle that radiation can be used with gold nanoparticles to modulate the release rates of protein-based drug-delivery vehicles, such as ZNPs.

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“…Chauhan et al designed gold-deposited zein nanoshells (AuZNS) by using GC polymer. [152] Positively charged GC was used for stabilization of negatively charged zein nanoparticles, which were prepared by antisolvent precipitation method by electrostatic interaction. Then, gold nanoparticles were deposited via ex situ method and the resulting AuZNS were 100 nm in diameter with an absorbance at 808 nm.…”

Section: Recent Advances In Theranostic Cnps For Cancer Heterogeneitymentioning

confidence: 99%

Tumor‐Targeting Glycol Chitosan Nanoparticles for Cancer Heterogeneity

et al. 2020

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liposomes (Doxil; liposomal doxorubicin (DOX), Onivyde; liposomal irinotecan, Vyxeos; liposomal daunorubicin plus cytarabine) and albumin nanoparticles (Abraxane; albumin nanoparticle-bound paclitaxel), being approved for clinical use and other nanocarriers being at different stages of clinical development. [2] Despite recent research and development of nanomedicines, the success rate of clinical translation remains poor, with patients in clinical settings benefitting from nanomedicines only through a reduction in side effects. [3] This is primarily because the enhanced accumulation of nanoparticles at tumor sites was initially overvalued in preclinical settings, with insufficient consideration given to tumor heterogeneity and complexity. [4] An analysis of studies published from 2005 to 2015 on the efficiency of nanoparticle delivery found that only 0.7% of the administered dose of nanoparticles was delivered to the tumor, irrespective of the materials, targeting strategy, hydrodynamic diameter, zeta potential, shape of nanoparticles, tumor model, and cancer type. [5] This low efficiency of delivery has prompted investigations to determine whether any key factors were omitted in the design and development of nanocarriers. A fundamental understanding of the key factors determining the tumor-targeting ability of nanoparticles is therefore required to optimize the design and development of nanoparticles with enhanced efficiency of delivery to tumors. Although many studies have assessed the impact of nanocarrier properties on the efficiency of targeted delivery, the effects of different factors are interconnected and often in opposition. For example, coating the surfaces of nanocarriers with poly(ethylene glycol) (PEG) extends their circulation in the blood by minimizing their detection by the immune system, thus contributing to targeted accumulation. However, PEG also reduces the uptake of nanocarriers by tumor tissue or tumor cells, reducing the accumulation of nanocarriers in tumors. Therefore, integrated analysis of the key factors found in a single type of nanoparticle with excellent tumor-targeting ability may provide insights into the entire procedure of developing new tumor-targeting nanocarriers. The relatively moderate therapeutic efficacy of nanomedicines in clinical settings may be due in part to tissue heterogeneity. The clinical benefits of nanomedicines have been reported to be highly variable and limited compared with their Nanomedicine is extensively employed for cancer treatment owing to its unique advantages over conventional drugs and imaging agents. This increased attention to nanomedicine, however, has not fully translated into clinical utilization and patient benefits due to issues associated with reticuloendothelial system clearance, tumor heterogeneity, and complexity of the tumor microenvironment. To address these challenges, efforts are being made to modify the design of nanomedicines, including optimization of their physiochemical properties, active targeting, and response to stimuli, but...

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Facile synthesis of plasmonic zein nanoshells for imaging-guided photothermal cancer therapy

Cited by 28 publications

References 55 publications

<p>Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene</p>

<p>Plasmonic MXene-based nanocomposites exhibiting photothermal therapeutic effects with lower acute toxicity than pure MXene</p>

Gold–Protein Composite Nanoparticles for Enhanced X-ray Interactions: A Potential Formulation for Triggered Release

Tumor‐Targeting Glycol Chitosan Nanoparticles for Cancer Heterogeneity

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