Facile synthesis of organosilica-capped mesoporous silica nanocarriers with selective redox-triggered drug release properties for safe tumor chemotherapy

Shen, Luying; S, Pan; Niu, Dechao; He, Jie; Jia, Xiaoxu; Hao, Ji‐Na; Gu, Jinlou; Zhao, Wenru; Li, Pei; Li, Yongsheng

doi:10.1039/c8bm01669k

Cited by 32 publications

(17 citation statements)

References 37 publications

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Section: Stimuli‐responsive Drug‐release Engineeringmentioning

confidence: 99%

“…With the rapid development of nanotechnology and biomedicine, drug delivery systems (DDSs) have been considered as the most practical and valuable targeted therapy strategy in diverse diseases, [ 1–8 ] such as cancer, [ 9–12 ] bone injury, [ 13–16 ] tissue defect, [ 17–19 ] infectious disease, [ 20 ] and so on. In terms of controlled drug release, the most critical part is the host functional nanocarrier, which enables to deliver guest therapeutic agents (e.g., doxorubicin (DOX), [ 6,21–23 ] ibuprofen, [ 24–26 ] alendronate, [ 27 ] gentamicin sulfate (GS), [ 28–31 ] or other anticancer drugs) and transfer to targeted cells or pathological tissues. These nanocarriers can precisely release drugs through stimuli‐responsive system to achieve a controllable and on‐demand therapy.…”

Section: Introductionmentioning

confidence: 99%

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Tailored Mesoporous Inorganic Biomaterials: Assembly, Functionalization, and Drug Delivery Engineering

et al. 2020

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Infectious or immune diseases have caused serious threat to human health due to their complexity and specificity, and emerging drug delivery systems (DDSs) have evolved into the most promising therapeutic strategy for drug‐targeted therapy. Various mesoporous biomaterials are exploited and applied as efficient nanocarriers to loading drugs by virtue of their large surface area, high porosity, and prominent biocompatibility. Nanosized mesoporous nanocarriers show great potential in biomedical research, and it has become the research hotspot in the interdisciplinary field. Herein, recent progress and assembly mechanisms on mesoporous inorganic biomaterials (e.g., silica, carbon, metal oxide) are summarized systematically, and typical functionalization methods (i.e., hybridization, polymerization, and doping) for nanocarriers are also discussed in depth. Particularly, structure–activity relationship and the effect of physicochemical parameters of mesoporous biomaterials, including morphologies (e.g., hollow, core–shell), pore textures (e.g., pore size, pore volume), and surface features (e.g., roughness and hydrophilic/hydrophobic) in DDS application are overviewed and elucidated in detail. As one of the important development directions, advanced stimuli‐responsive DDSs (e.g., pH, temperature, redox, ultrasound, light, magnetic field) are highlighted. Finally, the prospect of mesoporous biomaterials in disease therapeutics is stated, and it will open a new spring for the development of mesoporous nanocarriers.

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Section: Stimuli‐responsive Drug‐release Engineeringmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tailored Mesoporous Inorganic Biomaterials: Assembly, Functionalization, and Drug Delivery Engineering

et al. 2020

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“…e silica monolayer was formed after MPTMS immobilization on the surface of gold nanoparticles and hydrolysis in basic media [22]. Shen et al have synthesized PEGylated capped MSNs and covered with MPTMS, to be used as a gatekeeper [23]. Cheng et al reported the functionalization of MSNs with pH-sensitive trimethylammonium as pH-controllable drug release [24].…”

Section: Introductionmentioning

confidence: 99%

Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release

Alswieleh

2020

Journal of Chemistry

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This paper introduces the synthesis of mesoporous silica nanoparticles (MSNs) with three different groups such as amine, thiol, and sulfonic acid, along the internal surface. Trimethyl[3-(trimethoxysilyl)propyl]ammonium chloride was used to modify the external surface of the nanomaterials. Such materials allow control of the drug release from MSN pores. Multifunctional MSNs were loaded with doxycycline (Doxy) to study their capacities and uploading time. The loading profile indicates that sulfonic groups in the internal surface were the most efficient surfaces with a loading capacity of ca. 35% in 90 min in acidic media.

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“…[ 21 ] This method has been widely used in encapsulation and delivery of a variety of functionalities like, antitumor drugs, MRI CAs, and fluorescent dyes. [ 22 ] Wang et al have co‐assembled superparamagnetic iron oxide nanocrystals and conjugated polymers in organosilica cross‐linked micelles and achieved T 2 ‐weighted MRI and fluorescent bimodal imaging. [ 23 ]…”

Section: Introductionmentioning

confidence: 99%

Co‐Assembly of Gd(III)‐Based Metallosurfactant and Conjugated Polymer Nanoparticles in Organosilica Cross‐Linked Block Copolymer Micelles for Highly Efficient MRI and Fluorescent Bimodal Imaging

Zhu

et al. 2020

Part & Part Syst Charact

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/ppsc.202000044. Conformity of two biological imaging entities, magnetic resonance imaging (MRI) and fluorescence imaging, is achieved through co-assembly of a Gd(III)based metallosurfactant, conjugated polymeric nanoparticles, and amphiphilic block copolymer F127 (PEO 106 PPO 70 PEO 106 ) followed by crosslinking with organosilica. The cross-linked micelles with a size around 100 nm exhibit outstanding dispersion stability in aqueous and phosphate buffered saline solutions, bright fluorescence emission, and high relaxivities, providing a new approach to synthesize highly efficient bimodal contrast agents. The relaxivities of the co-assembled micelles are synergistically enhanced by incorporation of Gd(III) complexes with high hydration number (q = 3) and elongation of rotation correlation time to achieve r 1 values up to 105.37 mm −1 s −1 (at 1.5 T), which is over 20 times that of clinically used MRI contrast agents and among the highest values of all the nanoparticular MRI contrast agents. The external PEO layer endows these micelles with very low cytotoxicity for both in vitro and in vivo imaging. Meanwhile, thanks to the enhanced permeability and retention effect originating from their nanoscale sizes, the bimodal contrast agents show a prolonged blood circulation time in vivo and targeted accumulation at tumor regions to display outstanding MRI imaging performance. Scheme 1. Schematic illustration of the fabrication of the bimodal nanoparticular contrast agents.

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Facile synthesis of organosilica-capped mesoporous silica nanocarriers with selective redox-triggered drug release properties for safe tumor chemotherapy

Abstract: We develop a facile route to synthesize organosilica-capped mesoporous silica nanocarriers for efficient and safe redox-triggered tumor chemotherapy.

Cited by 32 publications

References 37 publications

Tailored Mesoporous Inorganic Biomaterials: Assembly, Functionalization, and Drug Delivery Engineering

Tailored Mesoporous Inorganic Biomaterials: Assembly, Functionalization, and Drug Delivery Engineering

Modification of Mesoporous Silica Surface by Immobilization of Functional Groups for Controlled Drug Release

Co‐Assembly of Gd(III)‐Based Metallosurfactant and Conjugated Polymer Nanoparticles in Organosilica Cross‐Linked Block Copolymer Micelles for Highly Efficient MRI and Fluorescent Bimodal Imaging

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