Facile Synthesis of Novel Chiral Bicyclic Thioureas and Their Crystal Structures

Abstract

The novel well-defined chiral bicyclic thioureas based on enantiopure unsymmetric <i>cis</i>-2,5-disustituted pyrrolidine skeleton were firstly synthesized and fully characterized by their <sup>1</sup>H NMR, <sup>13</sup>C NMR and HRMS. Their absolute configurations were also determined by single-crystal X-ray analysis

Facile Access to Unnatural Dipeptide-Alcohols Based on cis-2,5-Disubstituted Pyrrolidines

“…In our previous work, we reported the efficient construction of enantiopure unsymmetric cis -2,5-disubstituted pyrrolidines ( Figure 1 , compounds A – D ) using meso -diethyl-2,5-dibromoadipate and ( S )-(−)-1-phenylethylamine as starting materials [ 17 , 18 , 19 ]. Herein, we describe a facile route to unnatural dipeptide-alcohols from phenylalaninol and cis -2,5-disubstituted pyrrolidines.…”