Facile Synthesis of Novel Amino Acids Derivatives as Potential Antibacterial Agents using Sustainable Materials

Abstract

Following the principles of green chemistry, cardanol derivatives have been used as renewable, low‐cost, and available natural starting materials to construct a variety of protected and unprotected amino acids derivatives. The reaction of cardanol derivatives with different phthaloylamino acids including glycine, alanine, phenylalanine, and valine in the presence N,N'‐dicyclohexylcarbodiimide (DCC) as coupling reagent afforded high yields of the target compounds. Deprotection of phthaloylamino acids derivatives was achieved by heating with hydrazine hydrate. The chemical structures of all products were confirmed by spectral data (IR, MS, 1H NMR, 13C NMR) and elemental analyses. Antibacterial evaluation of the synthesized products was performed, which exhibited potent to weak activity in comparison with a standard drug.

Green design of novel heterocycles using deep eutectic solvent and evaluation of their cytotoxicity and antioxidant activities

“…In view of our continued interest in employing green chemistry principles to create bio-active heterocyclic compounds (31)(32)(33)(34)(35)(36), this study was directed towards the synthesis of a variety of bio-active heterocyclic compounds using chalcone derivatives as reactive key precursors in the presence of greener deep eutectic solvents. In addition, the products will be examined for their antitumor and antioxidant activities.…”

Green synthesis, cytotoxicity and antimicrobial activities of some new pyrazolines, pyrimidines and naphthyridines based on 1,3-di(thien-2-yl)prop-2-en-1-one using choline chloride-urea mixture as a deep eutectic solvent

“…In addition, pyrimidine derivatives are an important group of heterocyclic compounds that possess wide range of pharmacological properties, which include their uses as antimicrobial [17][18][19][20], anticancer [21][22][23][24][25], antitumor [26], antioxidant [27], anti-inflammatory [28] and antiviral [29].In view of these observations and in continuation to our ongoing interest in the design of bio-active heterocyclic molecules [30][31][32][33][34][35], the present work involves synthesis of chalcone derivatives using choline chloride-urea mixture as a deep eutectic solvent and construct a series of new heterocyclic molecules that have remarkable biological activities.…”

Efeito do análogo do cardanol hidrogenado no controle in vitro do fitopatógeno Lasiodiplodia theobramae.

“…A cajucultura é uma agroindústria que tem como resíduo do processamento industrial da castanha, o líquido da casca da castanha de caju (LCC) que pode ser utilizado como insumo na produção de resinas, tintas, dentre outros (ABREU et al, 2017;BEHALO, 2017).…”