Facile Synthesis of Nitrogen-Containing Six-Membered Benzofuzed Phenophosphazinine Oxides and Studies of the Photophysical Properties

Ye, Wenqiang; Li, Xiaobin; Ding, Bingbing; Wang, Chenchen; Shrestha, Mohini; Ma, Xiang; Chen, Yifeng; Tian, He

doi:10.1021/acs.joc.9b02847

Cited by 9 publications

(3 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[42][43][44] Since then, the literature has been extremely sparse on publications concerning these chemicals. 45,46 Due to the wealth of previously compiled research and a dearth of recent studies, dihydrophenphosphazines will be excluded from the remainder of this review.…”

Section: Azaphosphinine Originsmentioning

confidence: 99%

Azaphosphinines and their derivatives

McNeill,

Bard,

Johnson

et al. 2023

Chem. Soc. Rev.

View full text Add to dashboard Cite

show abstract

Section: Azaphosphinine Originsmentioning

confidence: 99%

Azaphosphinines and their derivatives

McNeill,

Bard,

Johnson

et al. 2023

Chem. Soc. Rev.

View full text Add to dashboard Cite

show abstract

“…Synthesis of starting materials. Compound 1a , 1b , 1c , and 1d were prepared according to literature method.…”

Section: Methodsmentioning

confidence: 99%

Synthesis, Photophysical and Electrochemical Properties of Spiro-Phosphonium Compounds

Zhao,

Li,

Wei

et al. 2024

J. Org. Chem.

View full text Add to dashboard Cite

A series of spiro-phosphonium compounds have been synthesized by copper-mediated coupling reaction of phosphacyclic compounds with alkynes. Their photophysical properties are tuned by varying substituents and exhibit different luminescent colors from blue to green, and finally, yellow. The fluorescence quantum efficiency of diethyl spiro-xanthenebenzophosphole 3aa in solid and liquid states reached 31% and 76%, respectively. Diphenyl spiroxanthenebenzophosphole 3ad displayed relatively low cytotoxicity toward lung cancer cells A549 and was able to effectively penetrate the cell membrane and maintain strong staining. Moreover, density functional theory (DFT) and timedependent DFT calculations have been performed to explore the origin of their photophysical properties.

show abstract

“…Another N‐bridged benzofuzed phenophosphazinine oxide (61) was synthesized using Tf 2 O to generate a phosphonium cation intermediate and 2,6‐lutidine to remove the acid. [ 95 ] Charge transfer characteristics were observed in 61a and 61b that could induce emission. 61b was emitted in the solution and solid states with a quantum yield higher than that of 61a , but the intensity decreased in the solid state compared to that in the solution state.…”

Section: Nonconventional Aie Fluorophores For Bioanalyte Detectionmentioning

confidence: 99%

Recent trends in molecular aggregates: An exploration of biomedicine

et al. 2022

View full text Add to dashboard Cite

Molecular aggregates are receiving tremendous attention, demonstrating immense potential for biomedical applications in vitro and in vivo. For instance, the molecular aggregates of conventional fluorophores influence the electronic excitation states of the aggregates, causing characteristic photophysical property changes. A fundamental understanding of this classical relationship between molecular aggregate structures and photophysics has allowed for innovative biological applications. The chemical characteristics of drug molecules generally trigger the formation of colloidal aggregates, and this is considered detrimental to the drug discovery process. Furthermore, nano-sized supramolecular aggregates have been used in biomedical imaging and therapy owing to their optimal properties for in vivo utility, including enhanced cell permeability, passive tumor targeting, and convenient surface engineering. Herein, we provide an overview of the recent trends in molecular aggregates for biomedical applications. The changes in photophysical properties of conventional fluorophores and their biological applications are discussed, followed by the effects of conventional drug molecule-aggregates on drug discovery and therapeutics development. Recent trends in the investigation of biologically important analytes with aggregation-induced emission are discussed for conventional and unconventional fluorophores. Lastly, we discuss nano-sized supramolecular aggregates used in imaging and therapeutic purposes, with a focus on in vivo utilization.

show abstract

Facile Synthesis of Nitrogen-Containing Six-Membered Benzofuzed Phenophosphazinine Oxides and Studies of the Photophysical Properties

Abstract: Scheme 1. Synthesis of Nitrogen-Containing Six-Membered Phosphacycles Note pubs.acs.org/joc

Cited by 9 publications

References 48 publications

Azaphosphinines and their derivatives

Azaphosphinines and their derivatives

Synthesis, Photophysical and Electrochemical Properties of Spiro-Phosphonium Compounds

Recent trends in molecular aggregates: An exploration of biomedicine

Contact Info

Product

Resources

About