Facile synthesis of monodispersed silica-coated magnetic nanoparticles

Rho, Won‐Yeop; Kim, Hyungmo; Kyeong, San; Kang, Yoo-Lee; Kim, Dong-Hyuk; Kang, Homan; Jeong, Cheolhwan; Kim, Dong-Eun; Lee, Jun Young; Jun, Bong‐Hyun

doi:10.1016/j.jiec.2013.12.014

Cited by 63 publications

(32 citation statements)

References 27 publications

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“…MSNs have been widely studied for their capability to load and release various drugs (Vallet-Reg ı, Balas, and Arcos 2007; Deodhar, Adams, and Trewyn 2017). More specifically, by creating a core-shell structure composed of an Fe 3 O 4 core surrounded by a mesoporous silica shell, magnetic properties have been added to MSNs (Rho et al 2014;Nyalosaso et al 2016). These magnetic MSNs (M-MSNs) are of particular interest in nanomedicine as targeting tools for theranostics, combining co-delivery of therapeutic and imaging functions in cancer diagnostics and therapy (Vivero-Escoto et al 2010;Xie, Lee, and Chen 2010;Li et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility assessment of functionalized magnetic mesoporous silica nanoparticles in human HepaRG cells

et al. 2017

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Magnetic mesoporous silica nanoparticles (M-MSNs) are a promising class of nanoparticles for drug delivery. However, a deep understanding of the toxicological mechanisms of action of these nanocarriers is essential, especially in the liver. The potential toxicity on HepaRG cells of pristine, pegylated (PEG), and lipid (DMPC) M-MSNs were compared. Based on MTT assay and real-time cell impedance, none of these NPs presented an extensive toxicity on hepatic cells. However, we observed by transmission electron microscopy (TEM) that the DMPC and pristine M-MSNs were greatly internalized. In comparison, PEG M-MSNs showed a slower cellular uptake. Whole gene expression profiling revealed the M-MSNs molecular modes of action in a time-and dose-dependent manner. The lowest dose tested (1.6 mg/cm 2 ) induced no molecular effect and was defined as 'No Observed Transcriptional Effect level.' The dose 16 mg/cm 2 revealed nascent but transient effects. At the highest dose (80 mg/cm 2 ), adverse effects have clearly arisen and increased over time. The limit of biocompatibility for HepaRG cells could be set at 16 mg/cm 2 for these NPs. Thanks to a comparative pathway-driven analysis, we highlighted the sequence of events that leads to the disruption of hepatobiliary system, elicited by the three types of MMSNs, at the highest dose. The Adverse Outcome Pathway of hepatic cholestasis was implicated. Toxicogenomics applied to cell cultures is an effective tool to characterize and compare the modes of action of many substances. We propose this strategy as an asset for upstream selection of the safest nanocarriers in the framework of regulation for nanobiosafety. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Biocompatibility assessment of functionalized magnetic mesoporous silica nanoparticles in human HepaRG cells

et al. 2017

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“…The preparation of silica-coated MNPs with good physical and chemical properties is a prerequisite for subsequent use. Rho et al [105] described a facile two-step method for synthesizing monodispersed, silica-coated MNPs. Oleate-MNPs were successfully converted to polyvinylpyrrolidone-MNPs (PVP-MNPs), which were then coated with silica using a modified version of the Stöber method.…”

Section: Silica-coated Mnpsmentioning

confidence: 99%

Magnetic drug delivery systems

Liu

Yang

et al. 2017

Sci. China Mater.

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There has been unprecedented progress in the development of biomedical nanotechnology and nanomaterials over the past few decades, and nanoparticle-based drug delivery systems (DDSs) have great potential for clinical applications. Among these, magnetic drug delivery systems (MDDSs) based on magnetic nanoparticles (MNPs) are attracting increasing attention owing to their favorable biocompatibility and excellent multifunctional loading capability. MDDSs primarily have a solid core of superparamagnetic maghemite (γ-Fe2O3) or magnetite (Fe3O4) nanoparticles ranging in size from 10 to 100 nm. Their surface can be functionalized by organic and/or inorganic modification. Further conjugation with targeting ligands, drug loading, and MNP assembly can provide complex magnetic delivery systems with improved targeting efficacy and reduced toxicity. Owing to their sensitive response to external magnetic fields, MNPs and their assemblies have been developed as novel smart delivery systems. In this review, we first summarize the basic physicochemical and magnetic properties of desirable MDDSs that fulfill the requirements for specific clinical applications. Secondly, we discuss the surface modifications and functionalization issues that arise when designing elaborate MDDSs for future clinical uses. Finally, we highlight recent progress in the design and fabrication of MNPs, magnetic assemblies, and magnetic microbubbles and liposomes as MDDSs for cancer diagnosis and therapy. Recently, researchers have focused on enhanced targeting efficacy and theranostics by applying step-by-step sequential treatment, and by magnetically modulating dosing regimens, which are the current challenges for clinical applications.

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“…The different effect of silica coating on magnetic properties of MNPs was reported in [7][8][9][10]. Superparamagnetic state characterized by weak inter-particle interaction was observed in magnetic nanoparticles coated by * corresponding author; e-mail: adriana.zelenakova@upjs.sk silica layer [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Effect of 1D Ordering on Magnetic Properties of Iron Nanoparticles coated by Silica Shell

et al. 2018

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Peculiar magnetic properties of 1D arranged composite consisting of Fe nanoparticles coated by insulating SiO2 layer were studied. Silica layer promotes the self-organization of 4 nm iron nanoparticles to the chain-like structures. Magnetization study shows that prepared nanoparticles exhibit very strong inter-particle magnetic interactions, which lead to long-range ordering of nanoparticles magnetic moments. Magnetic properties show superferromagnetic behaviour. The low value of room temperature coercivity, the existence of electrical insulating silica layer and small size of iron nanoparticles favour studied material for potential usage in microelectronic devices designed for high voltage signals modulated by high frequencies.

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Facile synthesis of monodispersed silica-coated magnetic nanoparticles

Cited by 63 publications

References 27 publications

Biocompatibility assessment of functionalized magnetic mesoporous silica nanoparticles in human HepaRG cells

Biocompatibility assessment of functionalized magnetic mesoporous silica nanoparticles in human HepaRG cells

Magnetic drug delivery systems

Effect of 1D Ordering on Magnetic Properties of Iron Nanoparticles coated by Silica Shell

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