Facile synthesis of manganese ferrite/graphene oxide nanocomposites for controlled targeted drug delivery

Wang, Guangshuo; Ma, Yingying; Zhang, Lina; Mu, Jingbo; Zhang, Zhixiao; Zhang, Xiaoliang; Che, Hongwei; Bai, Yongmei; Hou, Junxian

doi:10.1016/j.jmmm.2015.10.096

Cited by 52 publications

(21 citation statements)

References 21 publications

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“…In the last decade, the scientific interest towards magnetic nanostructured / nanocomposite materials has steadily increased owing to their functional properties associated with widespread applications ranging from electronics [1], magneto-optics and photocatalysis [2][3][4][5] to supercapacitors [6,7], hyperthermia [8], drug delivery [9,10], water remediation [11], energy harvesting [12]. Oxides of transition metals / rare earths have received particular attention because of the concurrence of magnetic effects and semiconducting-like properties [3,12,13] Magnetic metal-ceramic nanocomposites, consisting of a dispersion of Fe 0 , Co 0 , or Ni 0 nanoparticles into a prevailingly amorphous silica and alumina ceramic matrix, are an important sub-class of nanomaterials whose fields of application are typically associated with their porous structure, which makes them particularly suitable for use in environmental protection [14][15][16][17][18][19][20][21][22], catalysis [23][24][25][26][27][28] and biomedicine [29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

Magnetic clustering of Ni2+ ions in metal-ceramic nanocomposites obtained from Ni-exchanged zeolite precursors

Barrera

Tiberto

Esposito

et al. 2018

Ceramics International

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Metal-ceramic nanocomposites containing nominal 15% wt. Ni were produced by a smart, scalable process involving a suitable thermal treatment of Ni-exchanged zeolite precursors, and were investigated by dc magnetic techniques between 2 and 300 K. Two main magnetic phases were detected in all studied materials: globular magnetic nanoparticles with average diameters in the 10-20 nm range, and Ni2+ ions embedded in the host ceramic matrix. The blocking temperature of Ni0 nanoparticles is well above room temperature. The magnetic signal from nanoparticles dominates at high temperature; however, a clear paramagnetic signal from Ni2+ ions emerges when the temperature is decreased. The magnetic moment per Ni ion is in agreement with typical values found in Ni-containing zeolites. Magnetic susceptibility and FC/ZFC curves point to the existence of a weak interaction among Ni2+ ions (Néel temperature TN < 15 K) which results in the formation of ferrimagnetic-like clusters below about 30 K. In each cluster, the individual magnetic moments respond in a collective way with blocking temperatures less than 5 K.

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Section: Introductionmentioning

confidence: 99%

Magnetic clustering of Ni2+ ions in metal-ceramic nanocomposites obtained from Ni-exchanged zeolite precursors

Barrera

Tiberto

Esposito

et al. 2018

Ceramics International

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“…Generally, increasing temperatures from room temperature (298 K) to body temperature leads to higher rate of DOX release from different type of careers [ 32 ]. The pH value influences on hydrogen bonding strength created between -NH 2 and -OH of the DOX as well as –COOH and –OH of the nanotubes [ 33 ]. As a results acidic conditions weaken hydrogen bond which in turn causes higher release rate.…”

Section: Resultsmentioning

confidence: 99%

Description of Release Process of Doxorubicin from Modified Carbon Nanotubes

Chudoba

Jażdżewska

Łudzik

et al. 2021

IJMS

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The article discusses the release process of doxorubicin hydrochloride (DOX) from multi-wall carbon nanotubes (MWCNTs). The studies described a probable mechanism of release and actions between the surface of functionalized MWCNTs and anticancer drugs. The surface of carbon nanotubes (CNTs) has been modified via treatment in nitric acid to optimize the adsorption and release process. The modification efficiency and physicochemical properties of the MWCNTs+DOX system were analyzed by using SEM, TEM, EDS, FTIR, Raman Spectroscopy and UV-Vis methods. Based on computer simulations at pH 7.4 and the experiment at pH 5.4, the kinetics and the mechanism of DOX release from MWNT were discussed. It has been experimentally observed that the acidic pH (5.4) is appropriate for the efficient release of the drug from CNTs. It was noted that under acidic pH conditions, which is typical for the tumour microenvironment almost 90% of the drug was released in a relatively short time. The kinetics models based on different mathematical functions were used to describe the release mechanism of drugs from MWCNTs. Our studies indicated that the best fit of experimental kinetic curves of release has been observed for the Power-law model and the fitted parameters suggest that the drug release mechanism of DOX from MWCNTs is controlled by Fickian diffusion. Molecular dynamics simulations, on the other hand, have shown that in a neutral pH solution, which is close to the blood pH, the release process does not occur keeping the aggregation level constant. The presented studies have shown that MWCNTs are promising carriers of anticancer drugs that, depending on the surface modification, can exhibit different adsorption mechanisms and release.

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“…The nanoferrites can magnetically remove from the solution instead of the centrifugation process. The maximum wavelength for anticancer drugs are: Doxorubicin at 479 nm [23], Curcumin at 425 nm [34], Camptothecin at 480 nm, [68], 5-Fluorouracil at 266 nm [21], Cisplatin at 300 nm [18], Imanitib at 260 nm [31], Telmisartan at 296 nm [20], and Tamoxifen at 250 nm [55].…”

Section: Drugs Loaded On Functionalized Nanoferrites For Cancer Treatmentsmentioning

confidence: 99%

“…1. Anchored nanoferrites of cobalt [28] and manganese [23] on graphene oxide were developed for controlled drug delivery nanocomposites.…”

Section: Drugs Loaded On Functionalized Nanoferrites For Cancer Treatmentsmentioning

confidence: 99%

Nanoferrites-Based Drug Delivery Systems as Adjuvant Therapy for Cancer Treatments. Current Challenges and Future Perspectives

Osorio¹,

Herrera²,

Londoño³

et al. 2021

Ferrites - Synthesis and Applications

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Cancer is the second cause of death worldwide, whose treatment often involves chemotherapy. In a conventional therapy, drug is transported (and usually absorbed) across biological membranes through diffusion and systemic transport. The pathway that medicine must travel before reaching the desired location, can bring adverse or unwanted effects, which are mainly the result of: low bioavailability, low solubility and toxicity. To avoiding risks, nanoparticles coated with the drug could be used as a therapeutic substance to selectively reach an area of interest to act without affecting non-target cells, organs, or tissues (drug delivery). Here, the goal is to enhance the concentration of the chemotherapeutic drug in the disease parts of the body. Among all nanostructured systems, ferrites attract worldwide attention in drug delivery applications. It is due to their versatile magnetic and physicochemical properties. Here, it is reviewed and analyzed recent advances in synthesis, morphology, size, magnetic properties, functionalization with a focus in drug delivery applications of nanoferrites.

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Facile synthesis of manganese ferrite/graphene oxide nanocomposites for controlled targeted drug delivery

Cited by 52 publications

References 21 publications

Magnetic clustering of Ni2+ ions in metal-ceramic nanocomposites obtained from Ni-exchanged zeolite precursors

Magnetic clustering of Ni2+ ions in metal-ceramic nanocomposites obtained from Ni-exchanged zeolite precursors

Description of Release Process of Doxorubicin from Modified Carbon Nanotubes

Nanoferrites-Based Drug Delivery Systems as Adjuvant Therapy for Cancer Treatments. Current Challenges and Future Perspectives

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