Facile synthesis of hydroxypropyl chitosan-egg white hydrogel dressing with antibacterial and antioxidative activities for accelerating the healing of burn wounds

Zhao, Ying; Zhao, Yan‐Gang; Chu, Yuguo; Chang, Qiang

doi:10.1039/d3tb00210a

Cited by 5 publications

(6 citation statements)

References 75 publications

(87 reference statements)

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“…Aware of the excellent biocompatibility and antibacterial characteristics, researchers have utilized EW as a biomaterial in various applications, such as electro-spun fibers [44,48] and hydrogels [45,[49][50][51] for wound healing, nanocomposites [52,53], and microfibers [47,54,55] for bone tissue engineering. As bacterial infections represent a major cause of the failure of medical implants and devices, coating material surfaces with lysozyme from EW could be considered a promising strategy [56].…”

Section: Egg White (Ew)mentioning

confidence: 99%

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The Chicken Egg: An Advanced Material for Tissue Engineering

Zhang,

Pham,

Tran

2024

Biomolecules

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The chicken egg, an excellent natural source of proteins, has been an overlooked native biomaterial with remarkable physicochemical, structural, and biological properties. Recently, with significant advances in biomedical engineering, particularly in the development of 3D in vitro platforms, chicken egg materials have increasingly been investigated as biomaterials due to their distinct advantages such as their low cost, availability, easy handling, gelling ability, bioactivity, and provision of a developmentally stimulating environment for cells. In addition, the chicken egg and its by-products can improve tissue engraftment and stimulate angiogenesis, making it particularly attractive for wound healing and tissue engineering applications. Evidence suggests that the egg white (EW), egg yolk (EY), and eggshell membrane (ESM) are great biomaterial candidates for tissue engineering, as their protein composition resembles mammalian extracellular matrix proteins, ideal for cellular attachment, cellular differentiation, proliferation, and survivability. Moreover, eggshell (ES) is considered an excellent calcium resource for generating hydroxyapatite (HA), making it a promising biomaterial for bone regeneration. This review will provide researchers with a concise yet comprehensive understanding of the chicken egg structure, composition, and associated bioactive molecules in each component and introduce up-to-date tissue engineering applications of chicken eggs as biomaterials.

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Section: Egg White (Ew)mentioning

confidence: 99%

“…Another method is to introduce crosslinkers into EW, like glutaraldehyde (GA) and 1,4-butanediol diglycidyl ether (BDE) [16,62]. A third method, which is the most popular, is mixing and crosslinking EW with other molecules such as alginate, gelatin, and chitosan to form a composite or hybrid gel (Table 1) [10,49,57].…”

Section: Egg White (Ew)mentioning

confidence: 99%

The Chicken Egg: An Advanced Material for Tissue Engineering

Zhang,

Pham,

Tran

2024

Biomolecules

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“…For example, Zhao et al [76] designed an anti-inflammatory and antibacterial hydrogel based on egg white (EW) and hydroxypropyl chitosan (HPCS). The hydrogel accelerated deep skin burn wound healing by promoting cell proliferation and angiogenesis.…”

Section: F I G U R E 1mentioning

confidence: 99%

Multifunctional hydrogels for chronic wounds repairing

Wang,

Hu,

Han

et al. 2023

Biosurface and Biotribology

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Because of their tissue‐like mechanical performances, high biocompatibility, and adjustable functionality, hydrogels have become increasingly attractive materials for promoting wound healing. Chronic wounds include burn, diabetic, and infected wounds. Unlike common incision wounds, chronic wounds are more challenging to heal. To meet the clinical needs, multifunctional hydrogels should be fabricated and investigated. To guide future studies on the fabrication of hydrogel‐based chronic wound dressings, a review of advanced multifunctional hydrogels is necessary. Various hydrogels with advanced properties, such as antibacterial, antioxidant, bioadhesive, anti‐inflammatory, and wound healing properties, that can be used for skin burn wounds and diabetic wounds are summarised. Lastly, the prospects of advanced hydrogels for wound healing are elaborated.

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“…Skin wound management caused by violent trauma, surgical procedures, and extensive burns is a major global concern in public health. − The damage of skin breaks the primary physical barrier against external aggressions, making it highly vulnerable to bacterial invasion . The wound bed provides a warm and humid environment for bacterial proliferation and propagation accompanied by a continuous inflammatory response. , Bacterial infection results in delayed wound healing, tissue decay, and eventually serious complications, such as sepsis, amputation, or even death . Currently, bacterial infection of wounds is associated with high morbidity, which is a great challenge for patient recovery and medical expenditures. , Although traditional wound dressings such as cotton, , bandages, and gauze are widely used, − they mainly play an isolating role and are unable to create an antibacterial environment, restricting the repair of infected wounds.…”

Section: Introductionmentioning

confidence: 99%

“…5,6 Bacterial infection results in delayed wound healing, 7 tissue decay, 8 and eventually serious complications, such as sepsis, 9 amputation, 10 or even death. 11 Currently, bacterial infection of wounds is associated with high morbidity, which is a great challenge for patient recovery and medical expenditures. 12,13 Although traditional wound dressings such as cotton, 14,15 bandages, 16 and gauze are widely used, 17−19 they mainly play an isolating role and are unable to create an antibacterial environment, restricting the repair of infected wounds.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial, Fatigue-Resistant, and Self-Healing Dressing from Natural-Based Composite Hydrogels for Infected Wound Healing

Yan,

Hu,

Wang

et al. 2024

Biomacromolecules

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The treatment of infected wounds faces substantial challenges due to the high incidence and serious infection-related complications. Natural-based hydrogel dressings with favorable antibacterial properties and strong applicability are urgently needed. Herein, we developed a composite hydrogel by constructing multiple networks and loading ciprofloxacin for infected wound healing. The hydrogel was synthesized via a Schiff base reaction between carboxymethyl chitosan and oxidized sodium alginate, followed by the polymerization of the acrylamide monomer. The resultant hydrogel dressing possessed a good self-healing ability, considerable compression strength, and reliable compression fatigue resistance. In vitro assessment showed that the composite hydrogel effectively eliminated bacteria and exhibited an excellent biocompatibility. In a model of Staphylococcus aureus-infected full-thickness wounds, wound healing was significantly accelerated without scars through the composite hydrogel by reducing wound inflammation. Overall, this study opens up a new way for developing multifunctional hydrogel wound dressings to treat wound infections.

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Facile synthesis of hydroxypropyl chitosan-egg white hydrogel dressing with antibacterial and antioxidative activities for accelerating the healing of burn wounds

Abstract: Burn injury is the fourth most common injury in the world. Deep partial-thickness burns are susceptible to bacterial infections ascribing to the absence of skin shield which might lead to...

Cited by 5 publications

References 75 publications

The Chicken Egg: An Advanced Material for Tissue Engineering

The Chicken Egg: An Advanced Material for Tissue Engineering

Multifunctional hydrogels for chronic wounds repairing

Antibacterial, Fatigue-Resistant, and Self-Healing Dressing from Natural-Based Composite Hydrogels for Infected Wound Healing

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