Facile synthesis of hydrophilic polypyrrole nanoparticles for photothermal cancer therapy

Wang, Qian; Wang, Jiandong; Liu, Gang; Wang, Fang; Zhou, Xiaokai; Hu, Junqing; Wang, Qiugen

doi:10.1007/s10853-014-8061-2

Cited by 35 publications

(26 citation statements)

References 16 publications

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“…Upon irradiation, nanomaterials can scatter and absorb light, being this latter phenomenon responsible for the heat generation . Smaller nanomaterials scatter less light and can display a faster heat transfer to the surrounding environment due to their large surface area/volume ratio . In this way, nanomaterials with an improved photothermal capacity can be obtained by selecting nanostructures based on their size .…”

Section: Strategies Used To Augment Nanomaterials' Capacity To Producmentioning

confidence: 99%

“…Smaller nanomaterials scatter less light and can display a faster heat transfer to the surrounding environment due to their large surface area/volume ratio . In this way, nanomaterials with an improved photothermal capacity can be obtained by selecting nanostructures based on their size . Wang et al verified that despite 100 nm sized MoS 2 nanosheets exhibiting a higher NIR absorption than their 80 nm equivalents, the latter are capable of producing a greater temperature variation under laser irradiation due to their improved photothermal efficiency (ΔT ≈ 4.5 °C vs. ΔT ≈ 6 °C) .…”

Section: Strategies Used To Augment Nanomaterials' Capacity To Producmentioning

confidence: 99%

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Strategies to Improve Cancer Photothermal Therapy Mediated by Nanomaterials

Melo‐Diogo

Pais-Silva

Dias

et al. 2017

Adv Healthcare Materials

222

164

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The deployment of hyperthermia-based treatments for cancer therapy has captured the attention of different researchers worldwide. In particular, the application of light-responsive nanomaterials to mediate hyperthermia has revealed promising results in several pre-clinical assays. Unlike conventional therapies, these nanostructures can display a preferential tumor accumulation and thus mediate, upon irradiation with near-infrared light, a selective hyperthermic effect with temporal resolution. Different types of nanomaterials such as those based on gold, carbon, copper, molybdenum, tungsten, iron, palladium and conjugated polymers have been used for this photothermal modality. This progress report summarizes the different strategies that have been applied so far for increasing the efficacy of the photothermal therapeutic effect mediated by nanomaterials, namely those that improve the accumulation of nanomaterials in tumors (e.g. by changing the corona composition or through the functionalization with targeting ligands), increase nanomaterials' intrinsic capacity to generate photoinduced heat (e.g. by synthesizing new nanomaterials or assembling nanostructures) or by optimizing the parameters related to the laser light used in the irradiation process (e.g. by modulating the radiation wavelength). Overall, the development of new strategies or the optimization and combination of the existing ones will surely give a major contribution for the application of nanomaterials in cancer PTT.

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Section: Strategies Used To Augment Nanomaterials' Capacity To Producmentioning

confidence: 99%

Section: Strategies Used To Augment Nanomaterials' Capacity To Producmentioning

confidence: 99%

Strategies to Improve Cancer Photothermal Therapy Mediated by Nanomaterials

Melo‐Diogo

Pais-Silva

Dias

et al. 2017

Adv Healthcare Materials

222

164

View full text Add to dashboard Cite

show abstract

“…Carbon-based nanomaterials, including carbon nanotube 3 17 18 19 20 and graphene 21 22 , have also demonstrated promising photothermal properties, but certain limitations also exist, such as easy photobleaching, poor hydrophilicity and/or unsatisfactory photothermal conversion efficiency 23 . The other newly emerging photothermal agents such as semiconductor nanomaterials 16 24 25 and conjugated polymers 5 7 26 27 28 , which have also shown great potential for photothermal treatment, but their potential long-term toxicity and photothermal conversion efficiency remain central concerns for clinical applications 16 29 .…”

mentioning

confidence: 99%

Flower-like PEGylated MoS2 nanoflakes for near-infrared photothermal cancer therapy

Feng

Chen

Qin

et al. 2015

Sci Rep

249

147

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Photothermal cancer therapy has attracted considerable interest for cancer treatment in recent years, but the effective photothermal agents remain to be explored before this strategy can be applied clinically. In this study, we therefore develop flower-like molybdenum disulfide (MoS2) nanoflakes and investigate their potential for photothermal ablation of cancer cells. MoS2 nanoflakes are synthesized via a facile hydrothermal method and then modified with lipoic acid-terminated polyethylene glycol (LA-PEG), endowing the obtained nanoflakes with high colloidal stability and very low cytotoxicity. Upon irradiation with near infrared (NIR) laser at 808 nm, the nanoflakes showed powerful ability of inducing higher temperature, good photothermal stability and high photothermal conversion efficiency. The in vitro photothermal effects of MoS2-PEG nanoflakes with different concentrations were also evaluated under various power densities of NIR 808-nm laser irradiation, and the results indicated that an effective photothermal killing of cancer cells could be achieved by a low concentration of nanoflakes under a low power NIR 808-nm laser irradiation. Furthermore, cancer cell in vivo could be efficiently destroyed via the photothermal effect of MoS2-PEG nanoflakes under the irradiation. These results thus suggest that the MoS2-PEG nanoflakes would be as promising photothermal agents for future photothermal cancer therapy.

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“…In some cases, semicrystalline polymers can exhibit multiple melting endotherms which are generally attributed to the melting of imperfect crystals formed during the crystallization or formation of different crystal types depending on the presence of specific NA and/or thermomechanical history. Multiple melting endotherms have been reported for PA6, PA6 composites and blends, so far 50, 51, 15, 24…”

Section: Resultsmentioning

confidence: 99%

Effect of nucleating agent on the nonisothermal crystallization kinetics of glass fiber‐ and mineral‐filled polyamide‐6 composites

Şanlı

Durmuş

Ercan

2012

J of Applied Polymer Sci

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In this study, nonisothermal crystallization kinetics of glass fiber (GF) and clay-type mineral (MN)-reinforced polyamide-6 (PA6) composites prepared in a twin screw extruder were investigated by differential scanning calorimetry method in the presence and absence of an organic nucleating agent (NA). Kinetic parameters for the nonisothermal melt-crystallization process of samples were determined with several models namely Ozawa, Avrami, Jeziorny, and Liu-Mo. Crystallization rate parameters of the samples and nucleation activity of the fillers and additives were also calculated by the models suggested by Zhang and Dobreva and Gutzow, respectively. Crystallization activation energies of the samples were determined by the Kissinger model. It was found that the MN filler accelerates dramatically the crystallization rate of PA6 even without a NA. Small amount of NA also has a significant acceleration effect on the crystallization rate of PA6 composites. The rate acceleration effect of NA was found to be more pronounced in the composite sample reinforced with GF. Based on the kinetic study using of GF as major filler and small amount of clay-like MN in the PA6 composites could improve the mechanical properties and crystallization rate of injection-molded parts. V C 2012 Wiley Periodicals, Inc. J Appl Polym Sci 125: E268-E281, 2012

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Facile synthesis of hydrophilic polypyrrole nanoparticles for photothermal cancer therapy

Cited by 35 publications

References 16 publications

Strategies to Improve Cancer Photothermal Therapy Mediated by Nanomaterials

Strategies to Improve Cancer Photothermal Therapy Mediated by Nanomaterials

Flower-like PEGylated MoS2 nanoflakes for near-infrared photothermal cancer therapy

Effect of nucleating agent on the nonisothermal crystallization kinetics of glass fiber‐ and mineral‐filled polyamide‐6 composites

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