Facile Synthesis of Glycol Metabolites of Phenethylamine Drugs1

A recyclable copper catalysis in quinoxaline synthesis from α-hydroxyketones and o-phenylenediamines

“…The isolation of pure products was carried out via thin layer chromatography (silica gel 60 GF 254 , Merck). Except for 1-hydroxyhexan-2-one (2l), which was prepared by selective oxidation of diols [29], all a-hydroxyketones were synthesized by direct a-hydroxylation of ketones with [bis(trifluoroacetoxy)iodo]benzene and trifluoroacetic acid [30] as well as a-bromination of of ketones followed by hydroxylation [31,32]. Commercially available organic and inorganic compounds were used without further purification.…”