Facile synthesis of glucose-sensitive chitosan–poly(vinyl alcohol) hydrogel: Drug release optimization and swelling properties

Abureesh, Mosab Ali; Oladipo, Akeem Adeyemi; Gazi, Mustafa

doi:10.1016/j.ijbiomac.2015.10.001

Cited by 88 publications

(39 citation statements)

References 22 publications

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“…The strong intensity band at 1600 cm −1 and the absorption band at 1421 cm −1 are the result of the asymmetric and symmetrical stretching vibrations of the COO − group, respectively, and indicate the carboxymethylation of the biopolymer [12,17]. The weak band near 1421 cm −1 observed in the native lasiodiplodan (LN) sample has a peak near at 1419 cm −1 , and may have originated from OH deformation (from a non-carboxymethylated group) and C–H bending [18,19].…”

Section: Resultsmentioning

confidence: 99%

Fungal Exocellular (1-6)-β-d-glucan: Carboxymethylation, Characterization, and Antioxidant Activity

Theis

Santos

Appelt

et al. 2019

IJMS

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Exocellular (1→6)-β-d-glucan (lasiodiplodan) produced by the fungus Lasiodiplodia theobromae MMPI was derivatized by carboxymethylation using different concentrations of a derivatizing agent. Lasiodiplodan was derivatized by carboxymethylation in an attempt to increase its solubility and enhance its biological activities. Carboxymethylglucans with degrees of substitution (DS) of 0.32, 0.47, 0.51, 0.58, and 0.68 were produced and characterized. FTIR analysis showed a band of strong intensity at 1600 cm−1 and an absorption band at 1421 cm−1, resulting from asymmetric and symmetrical stretching vibrations, respectively, of the carboxymethyl group COO- in the carboxymethylated samples. Thermal analysis showed that native lasiodiplodan (LN) and carboxymethylated derivatives (LC) exhibited thermal stability up to 200–210 °C. X-ray diffractometry demonstrated that both native and carboxymethylated lasiodiplodan presented predominantly an amorphous nature. Scanning electron microscopy revealed that carboxymethylation promoted morphological changes in the biopolymer and increased porosity, and alveolar structures were observed along the surface. The introduction of carboxymethyl groups in the macromolecule promoted increased solubility and potentiated the hydroxyl radical-scavenging activity, suggesting a correlation between degree of substitution and antioxidant activity.

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Section: Resultsmentioning

confidence: 99%

Fungal Exocellular (1-6)-β-d-glucan: Carboxymethylation, Characterization, and Antioxidant Activity

Theis

Santos

Appelt

et al. 2019

IJMS

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“…The peak at 1627 cm −1 of the C ring -C=C stretch vibration confirms the presence of Cur in the CS-Cur-NPs. The broad adsorption band of the -OH and -NH 2 groups of CS at 3300–3500 cm −1 shifts towards smaller wavenumbers, and its intensity is reduced in the CS-Cur-NPs, while the peak at 1630 cm −1 (C=O stretching of amide I) to 1660 cm −1 indicates that extensive interactions like hydrogen bonds occurred between the reactive groups of CS and Cur [ 67 ].…”

Section: Resultsmentioning

confidence: 99%

Preparation and Evaluation of Collagen-Based Patches as Curcumin Carriers

Terzopoulou

Michopoulou²,

Palamidi

et al. 2020

Polymers

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Patients with psoriasis are dissatisfied with the standard pharmacological treatments, whether systemic or topical, with many of them showing interest in complementary and alternative medicine. Curcumin (Cur), a natural polyphenol derived from turmeric, has recently gained attention for skin-related diseases because of its proven anti-inflammatory action. However, topical treatment with Cur would be inadequate because of its hydrophobicity, instability, and low bioavailability. In addition, hyperkeratosis and lack of moisture in psoriatic skin result in low penetration that would prevent actives from permeating the stratum corneum. In this work, a polymer-based formulation of Cur for the topical treatment of psoriasis is reported. To improve the physicochemical stability of Cur, it was first encapsulated in chitosan nanoparticles. The Cur-loaded nanoparticles were incorporated in a hydrophilic, biocompatible collagen-based patch. The nanoparticle-containing porous collagen patches were then chemically cross-linked. Morphology, chemical interactions, swelling ratio, enzymatic hydrolysis, and Cur release from the patches were evaluated. All patches showed excellent swelling ratio, up to ~1500%, and after cross-linking, the pore size decreased, and their hydrolysis rates decelerated. The in vitro release of Cur was sustained with an initial burst release, reaching 55% after 24 h. Cur within the scaffolds imparted a proliferation inhibitory effect on psoriatic human keratinocytes in vitro.

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“…The results confirm that the formation of O-Na was the key preprocess for next cross-linking reaction and could accelerate [B(OH) 4 ] − reaction with the hydroxyl groups in PVA chains. A few previous studies have proved that boric acid is a Lewis acid, and when alkalinity is greater than pH of 9, a compact hydrogel network is formed through the chemical bonds between B(OH) 4 − and hydroxyl groups [33]. There was a decrease in intensity of peaks at 1144 and 1096 cm −1 , indicating that the crystallinity of PVA was modified by the interaction between PVA matrix and boric acid in the crystalline domains of PVA [20].…”

Section: Ftir and Xrd Analysis Of Pva Gel Beadsmentioning

confidence: 91%

Boric Acid Cross-linked 3D Polyvinyl Alcohol Gel Beads by NaOH-Titration Method as a Suitable Biomass Immobilization Matrix

Sun

Wang

et al. 2019

J Polym Environ

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Granule-base immobilization of biomass is a potential method for a decent quality granular sludge cultivation. In this study, 3D polyvinyl alcohol (PVA) gel beads were chemically cross-linked via a simple NaOH-titration method. The PVA gel beads' porous morphology was characterized using scanning electron microscope (SEM) and Brunauer-Emmette-Teller (BET), and their mechanical properties were evaluated by swelling rate and compressive stress tests. When cross-linking time was 10 min, high quality gel beads (P10) were synthesized, which demonstrated a homogeneous porous structure, good swelling rate, and high compressive strength. A mechanism for synthesis of the gel beads was proposed based on the results of Fourier transform infrared (FTIR) and X-ray diffractometer (XRD) analysis. Briefly, the intermolecular hydrogen bonds of PVA were firstly broken by NaOH to generate active bond of O-Na, which easily reacted with B(OH) 4 − to produce the PVA-boric acid gel beads. P10 showed excellent biocompatibility for anaerobic ammonia oxidation (anammox) biomass' immobilization. After incubation for three months, well granule-base immobilized sludge on P10 was developed in up-flow reactor. The sludge had high abundance of anammox biomass and was in balance with other functional bacteria. This work provides a simple method for the rapid preparation of 3D PVA gel beads and verifies their potential in granule-base immobilization of biomass.

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Facile synthesis of glucose-sensitive chitosan–poly(vinyl alcohol) hydrogel: Drug release optimization and swelling properties

Cited by 88 publications

References 22 publications

Fungal Exocellular (1-6)-β-d-glucan: Carboxymethylation, Characterization, and Antioxidant Activity

Fungal Exocellular (1-6)-β-d-glucan: Carboxymethylation, Characterization, and Antioxidant Activity

Preparation and Evaluation of Collagen-Based Patches as Curcumin Carriers

Boric Acid Cross-linked 3D Polyvinyl Alcohol Gel Beads by NaOH-Titration Method as a Suitable Biomass Immobilization Matrix

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