Facile synthesis of a CuSe/PVP nanocomposite for ultrasensitive non-enzymatic glucose biosensing

Rasheed, Momna; Saira, Farhat; Batool, Zahida; khan, Hasan M.; Yaseen, Junaid; Arshad, Muhammad; Kalsoom, Ambreen; Ahmed, Hafiz Ejaz; Ashiq, Muhammad Naeem

doi:10.1039/d3ra03175f

Cited by 6 publications

(4 citation statements)

References 57 publications

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“…Taken together, these data suggest that PVP interacts with the Cu 2– x Se surface through the O (of the CO). A similar interaction of PVP with Cu 2– x Se thin films has also been reported in other works. , XPS spectra of SDS-functionalized Cu 2– x Se NPs do not reveal clear evidence of either sulfur or oxygen-based Cu(II) interactions but also did not show evidence of residual CTAB (Figure S6). Therefore, considering both the steric and electronic structure of SDS, we reasoned that a Cu–O interaction would be most likely. , With these binding motifs, CTAB would exhibit the weakest interactions with the Cu 2– x Se surface (bond enthalpies: Se–N: 193 kJ, Cu–S: 285 ± 17 kJ, and Cu–O: 343 ± 63 kJ), − and exhibit the lowest equilibrium adsorption constant (excluding any additional intermolecular interactions or other surface–ligand interactions).…”

Section: Discussionsupporting

confidence: 87%

“…A similar interaction of PVP with Cu 2−x Se thin films has also been reported in other works. 63,64 XPS spectra of SDSfunctionalized Cu 2−x Se NPs do not reveal clear evidence of either sulfur or oxygen-based Cu(II) interactions but also did not show evidence of residual CTAB (Figure S6). Therefore, considering both the steric and electronic structure of SDS, we reasoned that a Cu−O interaction would be most likely.…”

Section: ■ Discussionmentioning

confidence: 99%

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Influence of Surface Chemistry on Metal Deposition Outcomes in Copper Selenide-Based Nanoheterostructure Synthesis

Sen,

Millheim,

Gordon

et al. 2024

Langmuir

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The use of nanoparticle surface chemistry to direct metal deposition has been well-studied in the modification of metal nanoparticle substrates but is not yet well-established for metal chalcogenide particle substrates, although integration of these particles into nanoheterostructures is of high interest. In this report, we investigate the effect of Cu2–x Se surface chemistry on the morphology of metal deposition on these plasmonic semiconductor nanoparticles. Specifically, we functionalize Cu2–x Se nanoparticles with a suite of 12 different ligands and investigate how different aspects of the ligand structure do or do not impact the morphology and extent of subsequent metal deposition on the Cu2–x Se surface. Surprisingly, our results indicate that the morphology of the resulting metal deposits and the extent of metal deposition onto the existing Cu2–x Se particle substrate are indistinguishable for the majority of ligands tested. An exception to these findings is observed for particles functionalized by quaternary alkylammonium bromides, which exhibit statistically distinct metal deposition patterns compared to all other ligands tested. We hypothesize that this unique behavior is due to a cooperative binding mechanism of the quaternary alkylammonium bromides to the surface of copper selenide. Taken together, these results yield both new strategies for controlling postsynthetic modification of copper selenide nanoparticles and also reveal limitations of surface chemistry-based approaches for this system.

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Section: Discussionsupporting

confidence: 87%

Section: ■ Discussionmentioning

confidence: 99%

Influence of Surface Chemistry on Metal Deposition Outcomes in Copper Selenide-Based Nanoheterostructure Synthesis

Sen,

Millheim,

Gordon

et al. 2024

Langmuir

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“…In Fourier transform infrared spectra (FTIR) (Figure S4), the peak at 633 cm –1 corresponded to the Cu–O stretching vibration in the Cu 2 O phase . The peak at 863 cm –1 indicated the presence of CuSe . The 633 cm –1 peak diminished and the 430 cm –1 peak increased, suggesting the AgNPs formed. , FTIR also confirmed the formation of CSA.…”

Section: Resultsmentioning

confidence: 72%

“…45 The peak at 863 cm −1 indicated the presence of CuSe. 46 The 633 cm −1 peak diminished and the 430 cm −1 peak increased, suggesting the AgNPs formed. 45,47 FTIR also confirmed the formation of CSA.…”

Section: Resultsmentioning

confidence: 97%

NIR-II-Responsive Versatile Nanozyme Based on H₂O₂ Cycling and Disrupting Cellular Redox Homeostasis for Enhanced Synergistic Cancer Therapy

ling,

Song,

Yang

et al. 2024

ACS Biomater. Sci. Eng.

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Disturbing cellular redox homeostasis within malignant cells, particularly improving reactive oxygen species (ROS), is one of the effective strategies for cancer therapy. The ROS generation based on nanozymes presents a promising strategy for cancer treatment. However, the therapeutic efficacy is limited due to the insufficient catalytic activity of nanozymes or their high dependence on hydrogen peroxide (H 2 O 2 ) or oxygen. Herein, we reported a nanozyme (CSA) based on well-defined CuSe hollow nanocubes (CS) uniformly covered with Ag nanoparticles (AgNPs) to disturb cellular redox homeostasis and catalyze a cascade of intracellular biochemical reactions to produce ROS for the synergistic therapy of breast cancer. In this system, CSA could interact with the thioredoxin reductase (TrxR) and deplete the tumor microenvironment-activated glutathione (GSH), disrupting the cellular antioxidant defense system and augmenting ROS generation. Besides, CSA possessed high peroxidase-mimicking activity toward H 2 O 2 , leading to the generation of various ROS including hydroxyl radical ( • OH), superoxide radicals ( • O 2 − ), and singlet oxygen ( 1 O 2 ), facilitated by the Cu(II)/Cu(I) redox and H 2 O 2 cycling, and plentiful catalytically active metal sites. Additionally, due to the absorption and charge separation performance of AgNPs, the CSA exhibited excellent photothermal performance in the second near-infrared (NIR-II, 1064 nm) region and enhanced the photocatalytic ROS level in cancer cells. Owing to the inhibition of TrxR activity, GSH depletion, high peroxidase-mimicking activity of CSA, and abundant ROS generation, CSA displays remarkable and specific inhibition of tumor growth.

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Exploring secondary optical transitions: a study utilizing the DITM method, and enhanced photocatalytic properties in Ni-doped CuSe

Ghobadi,

Zamani Meymian,

Fallah

2024

Sci Rep

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This study explores the simultaneous presence of two metal ions of Nickel (Ni) and Copper (Cu) on the formation of a metal selenide (Ni-doped CuSe) in an alkaline environment. The impact of Ni ions on creating the second optical transitions is investigated. Different concentrations amounts of Ni ions (0.01, 0.02, and 0.03 mol) are utilized to produce Ni-doped CuSe semiconductor thin films through a chemical solution deposition method with deposition times varying from 3 to 6 h. Absorbance spectra are employed to determine the band-gap, while Field Emission Scanning Electron Microscopy is utilized for morphological analysis. Structural and elemental analyses are conducted using X-ray Diffraction and Energy Dispersive X-ray Spectroscopy techniques. Additionally, a relatively innovative approach for determining the optical transitions, termed the Derivation Ineffective Thickness Method (DITM), is employed. DITM eliminates the need for thin film thickness and assumptions about the type of transition (direct or indirect) for band-gap calculation. Moreover, a comparison is made between the band-gap obtained from the Tauc model and the transitions obtained by DITM method. Furthermore, it is demonstrated that the optical transitions exhibit two distinct band-gaps associated with nickel selenide (NiSe) as second transition and copper selenide (CuSe) as fundamental transition. The presence of Ni is also found to enhance crystal quality. The study also briefly explores the improved photocatalytic properties of CuSe in the presence of Ni.

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Facile synthesis of a CuSe/PVP nanocomposite for ultrasensitive non-enzymatic glucose biosensing

Abstract: CuSe-PVP based non-enzymatic glucose biosensors show high sensitivity, lower response time, wide linear range and low cost.

Cited by 6 publications

References 57 publications

Influence of Surface Chemistry on Metal Deposition Outcomes in Copper Selenide-Based Nanoheterostructure Synthesis

Influence of Surface Chemistry on Metal Deposition Outcomes in Copper Selenide-Based Nanoheterostructure Synthesis

NIR-II-Responsive Versatile Nanozyme Based on H₂O₂ Cycling and Disrupting Cellular Redox Homeostasis for Enhanced Synergistic Cancer Therapy

Exploring secondary optical transitions: a study utilizing the DITM method, and enhanced photocatalytic properties in Ni-doped CuSe

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Facile synthesis of a CuSe/PVP nanocomposite for ultrasensitive non-enzymatic glucose biosensing

Abstract: CuSe-PVP based non-enzymatic glucose biosensors show high sensitivity, lower response time, wide linear range and low cost.

Cited by 6 publications

References 57 publications

Influence of Surface Chemistry on Metal Deposition Outcomes in Copper Selenide-Based Nanoheterostructure Synthesis

Influence of Surface Chemistry on Metal Deposition Outcomes in Copper Selenide-Based Nanoheterostructure Synthesis

NIR-II-Responsive Versatile Nanozyme Based on H2O2 Cycling and Disrupting Cellular Redox Homeostasis for Enhanced Synergistic Cancer Therapy

Exploring secondary optical transitions: a study utilizing the DITM method, and enhanced photocatalytic properties in Ni-doped CuSe

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NIR-II-Responsive Versatile Nanozyme Based on H₂O₂ Cycling and Disrupting Cellular Redox Homeostasis for Enhanced Synergistic Cancer Therapy