Facile synthesis of 5-arylidene rhodanine derivatives using Na2SO3 as an eco-friendly catalyst. Access to 2-mercapto-3-aryl-acrylic acids and a benzoxaborole derivative

Boureghda, Chaima; Boulcina, Raouf; Dorcet, Vincent; Berrée, Fabienne; Carboni, Bertrand; Debache, Abdelmadjid

doi:10.1016/j.tetlet.2020.152690

Cited by 6 publications

(1 citation statement)

References 48 publications

(44 reference statements)

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“…These molecules have been widely reported for their biological activity and their relevance in drug discovery, especially in the field of type 2 diabetes. There are many reports on their preparation using traditional solvents [ 93 ], but also on alternative methods that may include microwave technology [ 94 ] and green catalysts [ 95 ].…”

Section: Deep Eutectic Systemsmentioning

confidence: 99%

How Can Deep Eutectic Systems Promote Greener Processes in Medicinal Chemistry and Drug Discovery?

Domingues,

Duarte,

Jesus

2024

Pharmaceuticals

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Chemists in the medicinal chemistry field are constantly searching for alternatives towards more sustainable and eco-friendly processes for the design and synthesis of drug candidates. The pharmaceutical industry is one of the most polluting industries, having a high E-factor, which is driving the adoption of more sustainable processes not only for new drug candidates, but also in the production of well-established active pharmaceutical ingredients. Deep eutectic systems (DESs) have emerged as a greener alternative to ionic liquids, and their potential to substitute traditional organic solvents in drug discovery has raised interest among scientists. With the use of DESs as alternative solvents, the processes become more attractive in terms of eco-friendliness and recyclability. Furthermore, they might be more effective through making the process simpler, faster, and with maximum efficiency. This review will be focused on the role and application of deep eutectic systems in drug discovery, using biocatalytic processes and traditional organic chemical reactions, as new environmentally benign alternative solvents. Furthermore, herein we also show that DESs, if used in the pharmaceutical industry, may have a significant effect on lowering production costs and decreasing the impact of this industry on the quality of the environment.

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Section: Deep Eutectic Systemsmentioning

confidence: 99%